ID   A0A166Y4W4_9HYPO        Unreviewed;       740 AA.
AC   A0A166Y4W4;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE            EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN   ORFNames=BBO_08106 {ECO:0000313|EMBL:OAA36524.1};
OS   Beauveria brongniartii RCEF 3172.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria;
OC   Beauveria brongniartii.
OX   NCBI_TaxID=1081107 {ECO:0000313|EMBL:OAA36524.1, ECO:0000313|Proteomes:UP000076863};
RN   [1] {ECO:0000313|EMBL:OAA36524.1, ECO:0000313|Proteomes:UP000076863}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RCEF 3172 {ECO:0000313|EMBL:OAA36524.1,
RC   ECO:0000313|Proteomes:UP000076863};
RX   PubMed=27071652; DOI=10.1093/gbe/evw082;
RA   Shang Y., Xiao G., Zheng P., Cen K., Zhan S., Wang C.;
RT   "Divergent and convergent evolution of fungal pathogenicity.";
RL   Genome Biol. Evol. 8:1374-1387(2016).
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OAA36524.1}.
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DR   EMBL; AZHA01000035; OAA36524.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A166Y4W4; -.
DR   OrthoDB; 2712461at2759; -.
DR   Proteomes; UP000076863; Unassembled WGS sequence.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   Gene3D; 6.20.120.20; -; 1.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR002365; Terpene_synthase_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR   PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU362003};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022955};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022955};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Steroid biosynthesis {ECO:0000256|ARBA:ARBA00022955}.
FT   DOMAIN          96..386
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          401..731
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   740 AA;  84688 MW;  4D7C1B03DB23FA0C CRC64;
     MATTTGRETR SVRKRTNGSA RETAKSNVEG KTDYARWRLK DDDSRHTWHY LTDDDELDKW
     PQSNAEKYFL NLPLGLPNLP QATTAVDAAK NGINFFEKLQ LPSGHWACEY GGPMFLLPAV
     VCAWYATKTP IPEAYAMEIK NYLAARAHPE DGGWGLHIEG ESTVFGTSLN YTVLRLVGVD
     PEDPIMVRAR GTLHKLGGAL YAPHWAKFWL ATLGVMSWDI VNPIPPEIWL LPDWVPIAPW
     RWWIHSRQVF LSMSYVYSKK WSCPEDPIIR GLREELFVEP HAQINWASHR NSIAPEDNYH
     PKSWLLNSVN WVLVNIYNPY IRPNFIKNKA EAWCSQLIDM EDANTDYADL APVNAPMNTV
     VCYIRDGPEA FSVKRHIERL EEFLWVKDEG MLVNGTNGVQ CWDTAFLIQA VVEAGLHTDE
     RWRPMLTKAL RYLDRQQIRD NCVDQEKCYR QQRKGGWPFS NRDQGYGVSD CISEALKAII
     LVQKTEGYPE ALEDQRIYDA VDTLLLYQNS TGATSSYEAR RGGEYMELLN AAEVFGRIMI
     EYDYPECTTA CVTALSLFHK HWPVYRAAEI QTFIRRATSW IRGNQRPDGS WYGSWGICFT
     YATMFALESM ASVGEMYSNS NVSKRGCEFL LSKQRADGGW SESYKACETM TYVEHPMGSL
     VVQTAWALIG LMEAEYPDVE PLKKGIKLIV DRQQANGEWL QEAIEGVFNK SCMISYPNYK
     FTFTIKALGM FAKKFPDEKF
//