ID   A0A167CIC9_9HYPO        Unreviewed;      1010 AA.
AC   A0A167CIC9;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Pro-apoptotic serine protease NMA111 {ECO:0000256|ARBA:ARBA00020338};
DE   AltName: Full=Pro-apoptotic serine protease nma111 {ECO:0000256|ARBA:ARBA00021524};
GN   ORFNames=BBO_05767 {ECO:0000313|EMBL:OAA41231.1};
OS   Beauveria brongniartii RCEF 3172.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria;
OC   Beauveria brongniartii.
OX   NCBI_TaxID=1081107 {ECO:0000313|EMBL:OAA41231.1, ECO:0000313|Proteomes:UP000076863};
RN   [1] {ECO:0000313|EMBL:OAA41231.1, ECO:0000313|Proteomes:UP000076863}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RCEF 3172 {ECO:0000313|EMBL:OAA41231.1,
RC   ECO:0000313|Proteomes:UP000076863};
RX   PubMed=27071652; DOI=10.1093/gbe/evw082;
RA   Shang Y., Xiao G., Zheng P., Cen K., Zhan S., Wang C.;
RT   "Divergent and convergent evolution of fungal pathogenicity.";
RL   Genome Biol. Evol. 8:1374-1387(2016).
CC   -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC       {ECO:0000256|ARBA:ARBA00002558}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family.
CC       {ECO:0000256|ARBA:ARBA00010541}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OAA41231.1}.
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DR   EMBL; AZHA01000017; OAA41231.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A167CIC9; -.
DR   OrthoDB; 1779375at2759; -.
DR   Proteomes; UP000076863; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd00987; PDZ_serine_protease; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.40.10.120; -; 1.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   PANTHER; PTHR46366; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR   PANTHER; PTHR46366:SF8; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR   Pfam; PF12812; PDZ_1; 2.
DR   Pfam; PF13365; Trypsin_2; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022825};
KW   Protease {ECO:0000256|ARBA:ARBA00022825};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT   DOMAIN          388..464
FT                   /note="PDZ-like"
FT                   /evidence="ECO:0000259|Pfam:PF12812"
FT   DOMAIN          863..940
FT                   /note="PDZ-like"
FT                   /evidence="ECO:0000259|Pfam:PF12812"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1010 AA;  111632 MW;  B49F51F7A68F6185 CRC64;
     MNGHSMAGAK RKSSGSPDRA PAPKRVPNGN HSHDENTSDT DSIHYDDEFD LVDEGDMYSG
     TPVSLGEWQD TIQKVVRNVV AIRFCQTCSF DTDPALTSEA TGFVVDSERG YILTNRHVVG
     SGPFWGHCVF DNHEEVDCYP VYRDPVHDFG ILRYDPKALK YMQVDGLDLT PDQAKVGVEI
     RVVGNDAGEK LSILSGVISR LDRNAPEYGE GYSDFNTCYY QANAAASGGS SGSPVVCKDG
     TAVALQAGGR SDGASTDYFL PLDRPLRALQ CIQQGKPVTR GDIQCQFLLK PFDECRRLGL
     SPHWEAAIRQ EFPDETNMLV GEIILPDGPS HKKIEEGDVL IKVNGQLITQ FLRLDDILDS
     SVGQPIKLQL QRGGQDIEVE IEVGDLHKIT PDRFVSVAGA SFHDISYQQA RLYAVAVKGV
     YVCESAGSFR FDNTDNGWII QSVDNKKVPD LDTFIQVMKG IPDKARVVVK YKHLRDLHTL
     NTTVIYVDRH WSAKMKLAVR NDITGLWDFS DLGDPLPPVA PVRRSAAFIE LDHMPDPSIA
     KLIRSFVHIN CTMPVKLDGF PKNRRWGMGL VIDAEKGIVL ISRAVVPYDL CDITITIADS
     IIVEGKVLFL HPLQNYTIVK YDPSLVDAPV VSARLSSEPL TQGAKTHFLG YNRIGRVVHG
     STTVTEITAV AIPANSAAPR YRAVNVDAIT IDSNLGSSCN SGVLVAPDGT VQALWLSYLG
     ERSSCSQRDE EYYLGLGTPT LLPVISAIQR GEMPKLRLLS VEFRSIQMSQ ASVMGVSDEW
     IKKVTQANRS HHQLFMVSKR TFERGSMPVS LLEGDIILTL NGKICTTITD FDIMYSNTVL
     DAVIMRENEE IQLQLPTVPA EDLETDHAVA FCGAILHRPH QAVRQQISKL HSEVYVSSRI
     RGSPAYQYGV APTNFITHVN AEPTPDLDSF IAATRKIPDN TYFRLKAVTF DCVPWVITMK
     KNDHYFPTME WIKDNSEPCG WRRVTYEGAA VTNGEAVDGV PLPADDAEME
//