ID   A0A167DB42_9ASCO        Unreviewed;       515 AA.
AC   A0A167DB42;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=methionine--tRNA ligase {ECO:0000256|ARBA:ARBA00012838};
DE            EC=6.1.1.10 {ECO:0000256|ARBA:ARBA00012838};
GN   Name=MSM1 {ECO:0000313|EMBL:ANB12701.1};
GN   ORFNames=AWJ20_969 {ECO:0000313|EMBL:ANB12701.1};
OS   Sugiyamaella lignohabitans.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Trichomonascaceae; Sugiyamaella.
OX   NCBI_TaxID=796027 {ECO:0000313|EMBL:ANB12701.1, ECO:0000313|Proteomes:UP000189580};
RN   [1] {ECO:0000313|EMBL:ANB12701.1, ECO:0000313|Proteomes:UP000189580}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 10342 {ECO:0000313|EMBL:ANB12701.1,
RC   ECO:0000313|Proteomes:UP000189580};
RA   Bellasio M., Peymann A., Valli M., Sipitzky M., Graf A., Sauer M., Marx H.,
RA   Mattanovich D.;
RT   "Complete genome sequence and transcriptome regulation of the pentose
RT   utilising yeast Sugiyamaella lignohabitans.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363039}.
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DR   EMBL; CP014501; ANB12701.1; -; Genomic_DNA.
DR   RefSeq; XP_018735178.1; XM_018882939.1.
DR   AlphaFoldDB; A0A167DB42; -.
DR   GeneID; 30038059; -.
DR   KEGG; slb:AWJ20_969; -.
DR   OrthoDB; 166496at2759; -.
DR   Proteomes; UP000189580; Chromosome a.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006431; P:methionyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd00814; MetRS_core; 1.
DR   Gene3D; 2.170.220.10; -; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   InterPro; IPR041872; Anticodon_Met.
DR   InterPro; IPR014758; Met-tRNA_synth.
DR   InterPro; IPR023457; Met-tRNA_synth_2.
DR   InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR   InterPro; IPR033911; MetRS_core.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   NCBIfam; TIGR00398; metG; 1.
DR   PANTHER; PTHR43326:SF1; METHIONINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43326; METHIONYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF19303; Anticodon_3; 1.
DR   Pfam; PF09334; tRNA-synt_1g; 1.
DR   PRINTS; PR01041; TRNASYNTHMET.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363039};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363039};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363039};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189580}.
FT   DOMAIN          4..355
FT                   /note="Methionyl/Leucyl tRNA synthetase"
FT                   /evidence="ECO:0000259|Pfam:PF09334"
FT   DOMAIN          386..487
FT                   /note="Methionyl-tRNA synthetase anticodon-binding"
FT                   /evidence="ECO:0000259|Pfam:PF19303"
SQ   SEQUENCE   515 AA;  58847 MW;  E3FDC236D41DB882 CRC64;
     MHSMAVADLM KRWQVFLNPE RGGFMTTGTD EHGVKVEQAA KSVGRDTKEF VDETSQSFKI
     LADKAELDYD RFIRTTDKDH IEASQALWKI LQENGYIYQG THQGWYCVSD ETFYPETQIM
     RETVTKDGKE VEQMVSRETG KPVEWTSEVN YFFALSKLRD RLLEHIRSNK QFIVPEEKYR
     FVENEVAQGL SDLSISRPRS RCSWGVPVPG DEENQVMYVW LDALTNYLTS TGFPWKSEQA
     YLDSQWPADV HVVGKDILRF HTIYWPAFLL AAGIPVPKQV VVHSHWTIEG TKMSKSLGNV
     VDPIDTINKY GIDSVRYFLA NDSYLDHDTP FSNDRVQQRH NTDLVNRYGN LVVRICGPKF
     NINRSLAIDT DSIFENGQFS LPGIYDRHTA LVKQTNELLS NVSRFMSQYD SARALDQVWN
     LIKEANLFVQ DTAPWTYKSA DQVNLQDALI KDSAECARVA SIVLLPFLPL VANTMLDRLA
     VDKNKRSHQY AQYGADNSYG VSANRKGDYP IAGIE
//