ID A0A167DWY9_9ASCO Unreviewed; 313 AA.
AC A0A167DWY9;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Methylenetetrahydrofolate dehydrogenase (NAD(+)) {ECO:0000313|EMBL:ANB13393.1};
GN Name=MTD1 {ECO:0000313|EMBL:ANB13393.1};
GN ORFNames=AWJ20_1683 {ECO:0000313|EMBL:ANB13393.1};
OS Sugiyamaella lignohabitans.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Trichomonascaceae; Sugiyamaella.
OX NCBI_TaxID=796027 {ECO:0000313|EMBL:ANB13393.1, ECO:0000313|Proteomes:UP000189580};
RN [1] {ECO:0000313|EMBL:ANB13393.1, ECO:0000313|Proteomes:UP000189580}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 10342 {ECO:0000313|EMBL:ANB13393.1,
RC ECO:0000313|Proteomes:UP000189580};
RA Bellasio M., Peymann A., Valli M., Sipitzky M., Graf A., Sauer M., Marx H.,
RA Mattanovich D.;
RT "Complete genome sequence and transcriptome regulation of the pentose
RT utilising yeast Sugiyamaella lignohabitans.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP014501; ANB13393.1; -; Genomic_DNA.
DR RefSeq; XP_018735870.1; XM_018878581.1.
DR AlphaFoldDB; A0A167DWY9; -.
DR GeneID; 30033512; -.
DR KEGG; slb:AWJ20_1683; -.
DR OrthoDB; 2232005at2759; -.
DR Proteomes; UP000189580; Chromosome a.
DR GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR CDD; cd01079; NAD_bind_m-THF_DH; 1.
DR Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR035812; m-THF_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR000672; THF_DH/CycHdrlase.
DR InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR PANTHER; PTHR48099:SF3; METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]; 1.
DR Pfam; PF00763; THF_DHG_CYH; 1.
DR Pfam; PF02882; THF_DHG_CYH_C; 1.
DR PRINTS; PR00085; THFDHDRGNASE.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Reference proteome {ECO:0000313|Proteomes:UP000189580}.
FT DOMAIN 15..119
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00763"
FT DOMAIN 141..207
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF02882"
SQ SEQUENCE 313 AA; 35025 MW; 356F7A027F1B87BA CRC64;
MNTGANEVPE TVLASTVAKP FIEELRQGLE KLDRKPKLVG FLANSDPAAV KYADWTKKTS
EEIGFEYELR TLDKEDLEEG ILQANEDDLV DGIMVYFPVF GNRQDQYLQQ VLSPQKDVEG
LSHIYISNMY HNIRFLDKEK TQKSILPCTP LAIVKILEHL AVYNSVLPYG NRLYGKTVTV
INRSEIVGRP LAALLANDGA TVYSVDVTGV QKFTRGEGIK QIKHHVADVD TDWKEAAAQS
DVIITGVPSP DYKFPVELTK YGVVCINFSS EKNFGPEVKE HAALYVPSIG KVTIAMLLRN
LLRLIDNKKQ RSL
//
