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Database: UniProt
Entry: A0A167LYV0_PHYB8
LinkDB: A0A167LYV0_PHYB8
Original site: A0A167LYV0_PHYB8 
ID   A0A167LYV0_PHYB8        Unreviewed;       353 AA.
AC   A0A167LYV0;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   16-JAN-2019, entry version 17.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   ORFNames=PHYBLDRAFT_74916 {ECO:0000313|EMBL:OAD71369.1};
OS   Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 /
OS   NBRC 33097 / NRRL 1555).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Phycomycetaceae; Phycomyces.
OX   NCBI_TaxID=763407 {ECO:0000313|EMBL:OAD71369.1, ECO:0000313|Proteomes:UP000077315};
RN   [1] {ECO:0000313|EMBL:OAD71369.1, ECO:0000313|Proteomes:UP000077315}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 1555(-) {ECO:0000313|Proteomes:UP000077315};
RG   DOE Joint Genome Institute;
RA   Corrochano L.M., Kuo A., Marcet-Houben M., Polaino S., Salamov A.,
RA   Villalobos J.M., Alvarez M.I., Avalos J., Benito E.P., Benoit I.,
RA   Burger G., Camino L.P., Canovas D., Cerda-Olmedo E., Cheng J.-F.,
RA   Dominguez A., Elias M., Eslava A.P., Glaser F., Grimwood J.,
RA   Gutierrez G., Heitman J., Henrissat B., Iturriaga E.A., Lang B.F.,
RA   Lavin J.L., Lee S., Li W., Lindquist E., Lopez-Garcia S., Luque E.M.,
RA   Marcos A.T., Martin J., Mccluskey K., Medina H.R., Miralles-Duran A.,
RA   Miyazaki A., Munoz-Torres E., Oguiza J.A., Ohm R., Olmedo M.,
RA   Orejas M., Ortiz-Castellanos L., Pisabarro A.G., Rodriguez-Romero J.,
RA   Ruiz-Herrera J., Ruiz-Vazquez R., Sanz C., Schackwitz W., Schmutz J.,
RA   Shahriari M., Shelest E., Silva-Franco F., Soanes D., Syed K.,
RA   Tagua V.G., Talbot N.J., Thon M., De Vries R.P., Wiebenga A.,
RA   Yadav J.S., Braun E.L., Baker S., Garre V., Horwitz B.,
RA   Torres-Martinez S., Idnurm A., Herrera-Estrella A., Gabaldon T.,
RA   Grigoriev I.V.;
RT   "Expansion of signal transduction pathways in fungi by whole-genome
RT   duplication.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
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DR   EMBL; KV440986; OAD71369.1; -; Genomic_DNA.
DR   RefSeq; XP_018289409.1; XM_018443040.1.
DR   GeneID; 29003946; -.
DR   OrthoDB; 998704at2759; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000077315; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR022697; HDH_short.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF036497; HDH_short; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000077315};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR036497-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579};
KW   Reference proteome {ECO:0000313|Proteomes:UP000077315};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN        8    120       NAD_binding_3. {ECO:0000259|Pfam:
FT                                PF03447}.
FT   DOMAIN      141    344       Homoserine_dh. {ECO:0000259|Pfam:
FT                                PF00742}.
FT   NP_BIND       8     13       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   ACT_SITE    215    215       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR036497-1}.
FT   BINDING      77     77       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     101    101       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     200    200       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR036497-2}.
SQ   SEQUENCE   353 AA;  37482 MW;  AA03E69B4D627D8D CRC64;
     MVNIGIVGIG LVGAELVAQL KATSNKHLKV VAMTTSKKMV LSDTSYAPLT YANAQDLDAF
     AAYLAKSPEH AVIVDCTASD AVAKLYPSWL QSGVSVVTPN KKGFSGDLSL YRAIQASAAN
     LGKGGKTPLA FHESTVGAGL PVLSTLADLV KTGDKVISIE GIFSGTLSYL FNNFSSLSST
     TAARPFSEIV KVAKELGYTE PDPRDDLNGM DVARKVTICG RLAGLDLDLS TLEIQNIVPE
     PLQKVATAEE FMAQLPNFDG HFQKLNEEAK KENQVLRCVG LVDMKGGKSG VKLIKYPASH
     PFASLQGSDN IIKFTTEYFP NGLIIQGAGA GAAVTAYGIF SDLLKIQERV EGY
//
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