ID A0A167MT18_PHYB8 Unreviewed; 2555 AA.
AC A0A167MT18;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=MPN domain-containing protein {ECO:0000259|PROSITE:PS50249};
GN ORFNames=PHYBLDRAFT_145327 {ECO:0000313|EMBL:OAD73854.1};
OS Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC
OS 33097 / NRRL 1555).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Phycomycetaceae; Phycomyces.
OX NCBI_TaxID=763407 {ECO:0000313|EMBL:OAD73854.1, ECO:0000313|Proteomes:UP000077315};
RN [1] {ECO:0000313|Proteomes:UP000077315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 1555(-) {ECO:0000313|Proteomes:UP000077315};
RG DOE Joint Genome Institute;
RA Corrochano L.M., Kuo A., Marcet-Houben M., Polaino S., Salamov A.,
RA Villalobos J.M., Alvarez M.I., Avalos J., Benito E.P., Benoit I.,
RA Burger G., Camino L.P., Canovas D., Cerda-Olmedo E., Cheng J.-F.,
RA Dominguez A., Elias M., Eslava A.P., Glaser F., Grimwood J., Gutierrez G.,
RA Heitman J., Henrissat B., Iturriaga E.A., Lang B.F., Lavin J.L., Lee S.,
RA Li W., Lindquist E., Lopez-Garcia S., Luque E.M., Marcos A.T., Martin J.,
RA McCluskey K., Medina H.R., Miralles-Duran A., Miyazaki A., Munoz-Torres E.,
RA Oguiza J.A., Ohm R., Olmedo M., Orejas M., Ortiz-Castellanos L.,
RA Pisabarro A.G., Rodriguez-Romero J., Ruiz-Herrera J., Ruiz-Vazquez R.,
RA Sanz C., Schackwitz W., Schmutz J., Shahriari M., Shelest E.,
RA Silva-Franco F., Soanes D., Syed K., Tagua V.G., Talbot N.J., Thon M.,
RA De vries R.P., Wiebenga A., Yadav J.S., Braun E.L., Baker S., Garre V.,
RA Horwitz B., Torres-Martinez S., Idnurm A., Herrera-Estrella A.,
RA Gabaldon T., Grigoriev I.V.;
RT "Expansion of signal transduction pathways in fungi by whole-genome
RT duplication.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KV440980; OAD73854.1; -; Genomic_DNA.
DR RefSeq; XP_018291894.1; XM_018431417.1.
DR STRING; 763407.A0A167MT18; -.
DR GeneID; 28992323; -.
DR VEuPathDB; FungiDB:PHYBL_145327; -.
DR InParanoid; A0A167MT18; -.
DR OrthoDB; 246127at2759; -.
DR Proteomes; UP000077315; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0030623; F:U5 snRNA binding; IEA:InterPro.
DR GO; GO:0017070; F:U6 snRNA binding; IEA:InterPro.
DR GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR CDD; cd00081; Hint; 1.
DR CDD; cd08056; MPN_PRP8; 1.
DR CDD; cd13838; RNase_H_like_Prp8_IV; 1.
DR Gene3D; 1.20.80.40; -; 1.
DR Gene3D; 3.30.420.230; -; 1.
DR Gene3D; 3.90.1570.40; -; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 1.
DR Gene3D; 3.30.43.40; Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain; 1.
DR InterPro; IPR036844; Hint_dom_sf.
DR InterPro; IPR006141; Intein_N.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR012591; PRO8NT.
DR InterPro; IPR012592; PROCN.
DR InterPro; IPR012984; PROCT.
DR InterPro; IPR027652; PRP8.
DR InterPro; IPR021983; PRP8_domainIV.
DR InterPro; IPR043173; Prp8_domainIV_fingers.
DR InterPro; IPR043172; Prp8_domainIV_palm.
DR InterPro; IPR019581; Prp8_U5-snRNA-bd.
DR InterPro; IPR042516; Prp8_U5-snRNA-bd_sf.
DR InterPro; IPR019580; Prp8_U6-snRNA-bd.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR019582; RRM_spliceosomal_PrP8.
DR PANTHER; PTHR11140; PRE-MRNA SPLICING FACTOR PRP8; 1.
DR PANTHER; PTHR11140:SF0; PRE-MRNA-PROCESSING-SPLICING FACTOR 8; 1.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF08082; PRO8NT; 1.
DR Pfam; PF08083; PROCN; 1.
DR Pfam; PF08084; PROCT; 1.
DR Pfam; PF12134; PRP8_domainIV; 1.
DR Pfam; PF10598; RRM_4; 1.
DR Pfam; PF10597; U5_2-snRNA_bdg; 1.
DR Pfam; PF10596; U6-snRNA_bdg; 2.
DR SMART; SM00232; JAB_MPN; 1.
DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR PROSITE; PS50817; INTEIN_N_TER; 1.
DR PROSITE; PS50249; MPN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000077315};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 2325..2456
FT /note="MPN"
FT /evidence="ECO:0000259|PROSITE:PS50249"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 34..61
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2555 AA; 297586 MW; 5EB76F1027AC0F4C CRC64;
MDNSQSGIHV PVGSTPSMYN PNQQQYYNQY AYETNNQEQS AKSYEDRLNE KAKKWQQLQN
KRYGEKRKFG FIEHEKADMP PEHLRKIIKD HGDMSAKKFR HDKRIYLGAL KYVPHAVLKL
LENMPMPWEQ VREVSVLYHI TGAITFVNEI PWVIEPVYIA QWGTMWIMMR REKRDRRHFK
RMRFPPFDDE EPPLDYGDNI MDVEPLEAIQ MEMDDEEDAA VCDWFYDPKP LLDTKHVNGT
TYRKWRLDLP IMSTLYRLAH QLLSDMNDKN YFYLFDLNSF FTAKALSMAI PGGPKFEPLY
RDIDTSDEDW NEFNDINKII IRQPVRTEYK IAFPFLYNSL PRSVRVSWYH YPIVVYVRSE
DPDLPAFYFD PIVNPISSRT IESAGKQHED SIFGDGDEDT EFSLPEFIVP FLDETEISTE
NTANAIALYW APHPFDKRSG RTRRAQDVPL VKNWYLEHCP PNQPVKVRVS YQKLLKCYVL
NALKHRAPKA LNKKYLFRSL KSTKFFQTTQ LDWVEAGLQV CRQGYNMLNL LIHRKNLNYL
HLDYNFNLKP VKTLTTKERK KSRFGNAFHL CREILRLTKL IVDSHVQYRL GNVDAFQLAD
GLQYIFSHVG QLTGMYRYKY RLMRQIRMCK DLKHLIYYRF NTGPVGKGPG VGFWAPGWRV
WLFFMRGIVP LLERWLGNLL ARQFEGRHSK GIAKTVTKQR VDSHYDLELR AAVLHDITDA
MPEGIKGNKS RTILQHLSEA WRAWKANIPW KVPGMPTPIE NMILRYIKAK ADWWTSVAHY
NRERIRRGAT VDKTICRKNL GRLTRLWLKA EQERQHNYLK DGPYITAEEA VAIYTSTVHW
LESRKFSPIP FPPLSYKHDT KLLILALERL REAYSVQGRL NQSQREELGL IEQAYDNPHE
ALSRIKRLLL TQRAFKEVGI EFMDLYSHLI PVYDIEPLEK ITDAYLDQYL WYEADKRHLF
PAWIKPSDSE PPPLLVYKWC QGINNLTEVW DTSEGQCNVM LETQFSRVYE KVDLTLLGRL
LRLILDHNLA DYATAKNNVV LNYKDMNHVN AFGLIRGLQF ASFIFQYYGL VLDLLVLGLH
RASEMAGPPQ LPNDFLQYRD VTTETRHPIR LYSRYIDRLH IFFRFTADEA RDLIQRYLTE
HPDPNFENIV GYNNKKCWPR DCRMRLMKHD VNLGRAVFWD IKNRLPRSLT SIEWEESFVS
VYSKDNPNLL FSMSGFEVRI LPKSRSMTEE FTLKDGVWNL VNEQTKERTA QAYLRVDQES
MDKFHNRIRQ ILMASGSTTF SKIANKYNTA LIGLMTYYRE AVVHTRELLD LLVKCENKIQ
TRIKIGLNSK MPSRFPPVVF YTPKELGGLG MLSMGHVLIP QSDLRWSKQT ESGITHFRSG
MSHDEDTLIP NLYRYIQSWE SEFVDSQRVW AEYALKRQEA NAQNRRLTLE DLEDSWDRGI
PRINTLFQKD RHTLAYDKGW RVRTDFKQYQ VLKNNPFYWT HSRHDGKLWN LNNYRTDMIQ
ALGGVEGILE HTLFRGTYFT SWLGLFWEKA CFSGDTFLLL ADGNVKLARD ITTKDQFMGD
DGSPRTIIEC VDGVAPLYKV IPVSGEALEV TGNHILCLTT TSKSSLVWSD EDKIYTVRWF
SDEKGAQEFT TDSLQVVTDL VDSLEEDISA KDQEYFSEMT VREYMALPPS FQSTWLMYRA
EPEITKHNQS MVVAIKAVEL VPEPQTYYGF RIDGNQRFLR YDGLVVHNSG FEESMKYKKL
TNAQRSGLNQ IPNRRFTLWW SPTINRANVY VGFQVQLDLT GIFMHGKIPT LKISLIQIFR
AHLWQKIHEA LTMDFCQVFD RELEALQIET VQKETIHPRK SYKMNSSASD ILLFAAYKWP
VSRPSLLNDP KDIMDGPTTT KYWLDIQLRW GDFDSHDVER YTRAKFLDYT TDNMSIYPSP
TGLMIGVDLA YNLYSAYGNW IPGMKPLVQQ AMAKIMKANP ALYVLRERIR KALQLYSSEP
TEPYLSSTNY GELFSNQIIW FVDDTNVYRV TIHKTFEGNL TTKPINGAIF IFNPRTGQLF
LKIIHTSVWA GQKRLGQLAK WKTAEEVAAL IRSLPVEEQP KQIIVTRKGM LDPLEVHLLD
FPNIVIKGSE LQLPFQACLK VEKFGDLILK ATEPQMVLFN LYDDWLRTFS SYTAFSRLVL
ILRALHVNND KTKMILRPDR TTITEPHHIW PTLSDEEWAK VEVQLKDLIL ADYGKKNNVN
VASLTQSEIR DIILGMEIQA PSLQRQQIAE IEKQTKEQSQ LTAVTTKTRN IHGDEMIVTT
TSNYENATFA SKTEWRIRAI SATNLHLRTN HIYVNSDDIK ENTYTYVLPK NVLKRFITIS
DLRTQIAGFM YGVSPPDAPN VKEIRCVVIP PQWGTHQTVH LPNTLPEHEY LADLEPLGWI
HTQPQELMNI SPQDVTTHAK LLANNKSWDG EKAVALTCSF TPGSCSLTAY KITPGGFEWG
KNNMDTSSNP QGFLPTHAEK VQILLSDRFL GFFMAPSEIW NYNFMGAQFN ANMNYRLVLD
VPKEFYHESH RASHFMNFSS EMETGGEADI EDSFA
//
