ID A0A167RDG3_PHYB8 Unreviewed; 1327 AA.
AC A0A167RDG3;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=PHYBLDRAFT_25598 {ECO:0000313|EMBL:OAD81407.1};
OS Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC
OS 33097 / NRRL 1555).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Phycomycetaceae; Phycomyces.
OX NCBI_TaxID=763407 {ECO:0000313|EMBL:OAD81407.1, ECO:0000313|Proteomes:UP000077315};
RN [1] {ECO:0000313|Proteomes:UP000077315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 1555(-) {ECO:0000313|Proteomes:UP000077315};
RG DOE Joint Genome Institute;
RA Corrochano L.M., Kuo A., Marcet-Houben M., Polaino S., Salamov A.,
RA Villalobos J.M., Alvarez M.I., Avalos J., Benito E.P., Benoit I.,
RA Burger G., Camino L.P., Canovas D., Cerda-Olmedo E., Cheng J.-F.,
RA Dominguez A., Elias M., Eslava A.P., Glaser F., Grimwood J., Gutierrez G.,
RA Heitman J., Henrissat B., Iturriaga E.A., Lang B.F., Lavin J.L., Lee S.,
RA Li W., Lindquist E., Lopez-Garcia S., Luque E.M., Marcos A.T., Martin J.,
RA McCluskey K., Medina H.R., Miralles-Duran A., Miyazaki A., Munoz-Torres E.,
RA Oguiza J.A., Ohm R., Olmedo M., Orejas M., Ortiz-Castellanos L.,
RA Pisabarro A.G., Rodriguez-Romero J., Ruiz-Herrera J., Ruiz-Vazquez R.,
RA Sanz C., Schackwitz W., Schmutz J., Shahriari M., Shelest E.,
RA Silva-Franco F., Soanes D., Syed K., Tagua V.G., Talbot N.J., Thon M.,
RA De vries R.P., Wiebenga A., Yadav J.S., Braun E.L., Baker S., Garre V.,
RA Horwitz B., Torres-Martinez S., Idnurm A., Herrera-Estrella A.,
RA Gabaldon T., Grigoriev I.V.;
RT "Expansion of signal transduction pathways in fungi by whole-genome
RT duplication.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; KV440971; OAD81407.1; -; Genomic_DNA.
DR RefSeq; XP_018299447.1; XM_018439874.1.
DR STRING; 763407.A0A167RDG3; -.
DR GeneID; 29000780; -.
DR VEuPathDB; FungiDB:PHYBL_25598; -.
DR InParanoid; A0A167RDG3; -.
DR OrthoDB; 147843at2759; -.
DR Proteomes; UP000077315; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 2.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000077315};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 765..943
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1049..1311
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1327 AA; 151792 MW; 6A9EB3F9083B5CA2 CRC64;
MSKNRGAIEI PLTFRLGSLL PVLKTLLEHD DLNPHEKPSE ETVALFRNLW FHCILFGFVS
ESMWVREWHE SMLIIAKKTP VLVIESATSY LESDLECNSV LRGSNTSDQI INQTRQRLTG
FLPSLAYDIK SFSFAQVVFA SSVYHIEMMR SRMGNCSHIL RYFMNEGVNS SPLSKCLETI
ADRVIGTFVK DASSKALTQT LGDELPTQVA ILLERCCHRL RKVHELAIKS TERIVISFPQ
IFVEKKLVTL LLELVQLLWL SCEAEYREEY SPQYYFTSKK VGVTLELGDS YSYRKEICSR
LYESAKKWLL IAIDRAPLET SGLLQDYMSD FDRFGSGGIF DTAHLGRSLA LEIGRISSKS
QLSLGFAPKI SSISLDDSSN FVDGFVSKQF YSGEVSGIEY SAKTKSQFGI LSEPTPTTGI
KDELESVLSF LSFLANDVKH KKKVASERLN RSLKRAAGYA IAMPEVHPEL LRYLVRIPVE
MFTPESLDIG TSVWNWILVK RPDMEKRLMV EMLSMWSWAQ RHRKGLFSPL LNSKNPFVVK
MSYAPSDNAV REREHKAAML IFSPHNSWIK FLSSRFYAIR HRNKHLVNML VRLLQESFND
ADLMSTHPLS RYTRFQLLRL GMKILRSTRM EALAEHKFRS LVYDASFQWF SFDPKWHFGA
RRSLALMEHK LLNDFYNAVS TDTPNLTYLV TSVPMKTSNS KVSSDKTKDD VVRQHQLSKK
LLMLFLESEL VRLSVWCNPM NETSVGYPAT IVSNTEKSMV TDDVWKDMVH FAWTISPRLA
VQMDSRFVQP IVHRELHHLI ANNTLDVVDI PEALVILLGE RLVPGSKLDL KYLQYWAPVP
AITATSYFLP TYNNHPLILQ YAMRSLEYYP VDTVFFYIPQ IVQALRFDDL GYVEKYIMEA
GQVSQLFAHQ LIWNMKANFF VDADKDCLRP DSLKPTLEKI IENLAGSFTG EDREFYEREF
KFFGEVTAIS GYLKEYIKFG QNEKKPLQKK RLDEEIANIV VDKGVYLPSN SDGRVIDINR
KSGRPLQSHA KAPFMATFEI EKDVEVDPIA NSLLSEEEQQ MNKSMTIKAW QGAIFKVGDD
CRQDVLALQL IAVFKNIFTS VGLDLYVYPY RVVATAPGCG VIDVIPRSIS RDQLGREKVN
NMYDYFVAKY GGPESIHFQK ARTNFVQSVA AYSVISYLLQ IKDRHNGNIM LDDDGHIIHI
DFGFIFDIAP GGITFENSPF KLTTEMIQVM GGTPEQGYKK FSELVIKAYL ACRPYAELIM
QLVSLMLQSG LPCFKGETIK RMRGRFQLDK SERAAADFMT MCIQVSSENQ RTVLYDRFQK
LTNGIPF
//
