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Database: UniProt
Entry: A0A167Y6T2_9FLAO
LinkDB: A0A167Y6T2_9FLAO
Original site: A0A167Y6T2_9FLAO 
ID   A0A167Y6T2_9FLAO        Unreviewed;       796 AA.
AC   A0A167Y6T2;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   08-MAY-2019, entry version 17.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:OAB29085.1};
GN   ORFNames=FBFR_06465 {ECO:0000313|EMBL:OAB29085.1};
OS   Flavobacterium fryxellicola.
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=249352 {ECO:0000313|EMBL:OAB29085.1, ECO:0000313|Proteomes:UP000077164};
RN   [1] {ECO:0000313|EMBL:OAB29085.1, ECO:0000313|Proteomes:UP000077164}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16209 {ECO:0000313|EMBL:OAB29085.1,
RC   ECO:0000313|Proteomes:UP000077164};
RA   Shin S.-K., Yi H.;
RT   "Draft genome sequence of Flavobacterium fryxellicola DSM 16209.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OAB29085.1}.
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DR   EMBL; LVJE01000010; OAB29085.1; -; Genomic_DNA.
DR   RefSeq; WP_066078489.1; NZ_LVJE01000010.1.
DR   EnsemblBacteria; OAB29085; OAB29085; FBFR_06465.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000077164; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1040.10; -; 2.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000077164};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296}.
FT   DOMAIN        7    205       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      208    307       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   COILED      546    566       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   796 AA;  88163 MW;  FE2C54A708833EE3 CRC64;
     MKRTIKKVAV IGSGIMGSGI ACHFANIGVE VLLLDIVPRE LTEVEAKKGL TLESKIVRNR
     LVNEHLANSL KSKPSPIYSQ QFASRITTGN TSDDMAKIAT ADWIIEVVVE RLDIKKMVFE
     QIEKFRKPGT LVTSNTSGIP IHFMSEGRSE DFQKHFCGTH FFNPARYLKL FEIIPGPQTA
     TEVLDFLTDY GSRFLGKTSV VAKDTPAFIG NRIGIYGIQS LFHLVKEMGL TIEEVDKLTG
     PVIGRPKSAT FRTVDVVGLD TLVHVANGIY ENCPTDEQHD LFKLPDFVNK MMENKWLGSK
     TGQGFYKKVD KDILSLDLDT LEYRPAKKAS FATLELTKTI DKPIDRFKVL VKGKDKAGEF
     YRKSFAGMFA YVSNRIPEIS DEVYKIDDAM KAGFGWENGP FEIWDAIGVE KGIEIMKAEG
     LEPAAWVTEM LASGSSSFYS VKEGATFFYN IPTKSQNKVP GQDAFIILNN IRESKKIWSN
     SGAIIQDLGD GILNLEFQSK MNTIGGDVLQ AINKAIDLSE KEYQGLVIGN QAANFSVGAN
     IGMIFMMAVE QEYDELNMAI KMFQDTMMRV RYSGIPVVVA PHGMTFGGGC EMSLHADKVV
     AAAETYMGLV EFGVGVIPGG GGSKELAMRA SDLFHKNDVE LNVLQEYFLT IAMAKVSTSG
     YEAFDTGLLQ KGKDIIVVNK DRQIAEAKKH ALLMAEAGYT QPIRRTDVKV LGKQALGMFL
     VGTDQMEAGK YISEHDKKIA NKLAYVMAGG DLSEPTLVSE QYLLDLEREA FLSLCTERKT
     LERIQFMLTK GKPLRN
//
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