ID   A0A167Z3X2_9HYPO        Unreviewed;       730 AA.
AC   A0A167Z3X2;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Translation initiation factor eIF2B subunit epsilon {ECO:0000256|ARBA:ARBA00044144};
DE   AltName: Full=eIF2B GDP-GTP exchange factor subunit epsilon {ECO:0000256|ARBA:ARBA00044345};
GN   ORFNames=AAL_06341 {ECO:0000313|EMBL:KZZ92131.1};
OS   Moelleriella libera RCEF 2490.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Moelleriella.
OX   NCBI_TaxID=1081109 {ECO:0000313|EMBL:KZZ92131.1, ECO:0000313|Proteomes:UP000078544};
RN   [1] {ECO:0000313|EMBL:KZZ92131.1, ECO:0000313|Proteomes:UP000078544}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RCEF 2490 {ECO:0000313|EMBL:KZZ92131.1,
RC   ECO:0000313|Proteomes:UP000078544};
RX   PubMed=27071652; DOI=10.1093/gbe/evw082;
RA   Shang Y., Xiao G., Zheng P., Cen K., Zhan S., Wang C.;
RT   "Divergent and convergent evolution of fungal pathogenicity.";
RL   Genome Biol. Evol. 8:1374-1387(2016).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
CC   -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC       {ECO:0000256|ARBA:ARBA00007878}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KZZ92131.1}.
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DR   EMBL; AZGY01000016; KZZ92131.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A167Z3X2; -.
DR   STRING; 1081109.A0A167Z3X2; -.
DR   OrthoDB; 5474157at2759; -.
DR   Proteomes; UP000078544; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR   CDD; cd04197; eIF-2B_epsilon_N; 1.
DR   CDD; cd05787; LbH_eIF2B_epsilon; 1.
DR   CDD; cd11558; W2_eIF2B_epsilon; 1.
DR   Gene3D; 1.25.40.180; -; 1.
DR   Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR035543; eIF-2B_epsilon_N.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR003307; W2_domain.
DR   InterPro; IPR044123; W2_eIF2B_epsilon.
DR   PANTHER; PTHR45887; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR   PANTHER; PTHR45887:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR   Pfam; PF02020; W2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR   PROSITE; PS51363; W2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078544}.
FT   DOMAIN          537..721
FT                   /note="W2"
FT                   /evidence="ECO:0000259|PROSITE:PS51363"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          503..531
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          711..730
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        712..730
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   730 AA;  79580 MW;  E44D0BE03C44DEB4 CRC64;
     MSHKGKRSAG KGGKPPAKTS TENKGEDVLR AVLIADSFQD RFKPFTINKP RCLLPLANTP
     LIEYTLEFLA MNGVNEVYIY CGAFTNQVED YISRSRWATS LPSSPFSVVQ FVRVSDARSV
     GDILRDLDKR ALVDGDFLVV HGDLVSNFLL DETLAAHRKR RETSAANIMT VVLRSGGLER
     HRTQTNGITP IFAVDKKTQR LLHYDEMSPL QSDHYLALDP AIADELSADF ELRADLIDAH
     VDICTPEVLA LWSESFDYEL PRRNFLHGVL KDWELNGKMI YAAILEDGYA ARASNLQMYD
     SISRDILGGW TPPFIPENNL LPSQTYERQG NGVVMEQGAS HAYDARLTDT VIGAGTTIGP
     GTRISNCFIG KGCKIGAKVV LEDSYIWDDT TIEEGSSVTH AVIGDSVTVG KRCILTAGSL
     IASGVRIGAE TKLTGSTILT ALTPSGEPVT KDTRLLGSDT NAARFFDPDQ DDLDDRDPSR
     LQRSLIYSLA GLNLSSSTLS TLASDADSDD EQDDDHPSLG AGDSSRSRLS SFASDDSTGK
     IDFHADAVHG LLDALRADSS DFDSAKLEFM GLRLANDASD GMMRRAVATA FARRAAELLT
     REHGSLDAAK AAEKAITSKK GASTFIDEVG IGGQESEQVE FILAVQKALQ HTKAPDQGKL
     GTLLAAMLQQ LYALDVLEED GILAWWEDER AGEGEIMASL RERCKALVEY LENADDDDDD
     DDDDDSDDEE
//