ID A0A168AFY2_9HYPO Unreviewed; 438 AA.
AC A0A168AFY2;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Ketoisovalerate reductase {ECO:0000313|EMBL:KZZ93882.1};
GN ORFNames=AAL_05598 {ECO:0000313|EMBL:KZZ93882.1};
OS Moelleriella libera RCEF 2490.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Moelleriella.
OX NCBI_TaxID=1081109 {ECO:0000313|EMBL:KZZ93882.1, ECO:0000313|Proteomes:UP000078544};
RN [1] {ECO:0000313|EMBL:KZZ93882.1, ECO:0000313|Proteomes:UP000078544}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCEF 2490 {ECO:0000313|EMBL:KZZ93882.1,
RC ECO:0000313|Proteomes:UP000078544};
RX PubMed=27071652; DOI=10.1093/gbe/evw082;
RA Shang Y., Xiao G., Zheng P., Cen K., Zhan S., Wang C.;
RT "Divergent and convergent evolution of fungal pathogenicity.";
RL Genome Biol. Evol. 8:1374-1387(2016).
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZZ93882.1}.
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DR EMBL; AZGY01000012; KZZ93882.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A168AFY2; -.
DR STRING; 1081109.A0A168AFY2; -.
DR OrthoDB; 1354873at2759; -.
DR Proteomes; UP000078544; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR PANTHER; PTHR43765; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR PANTHER; PTHR43765:SF2; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000078544}.
FT DOMAIN 50..221
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 257..422
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 438 AA; 48283 MW; E08F6ACC901E7310 CRC64;
MSRLQQPTWL KTLLAKRGPP PKLYAWTPAN LDPLPRRLSP SRQSSLDERI FILGVGNIGL
LFATGLARHP NPAPITLVVH RKDLLSQWHQ GQGLQLTQDG LTTRNKQFDI EWWTESRPER
GPVREVADGG KLRNLLISTK TSAAMPEADR LRRYLDKSSS VVFAQNGMSK LWPPHGPLYV
AGQYEPGGAP NFSACVINHG LFSTGPFQST YKAPADASIG PVLVNPEFAP RGGFLSRQIT
TSPLLKTRAV SSGQLWLLQL EKLVVNAIIN PLTALLRCEN GYIFSSRDPQ HPLVRVQSRL
LAEISAVLQA FVNHESNHNL IASCAERFHA GNLSNQKHGQ QEGLEIVKRD ITHRFSPERL
QEKLHALAII VGKNRSSMLQ DVEAGKKTEV GDFNGWIVDT AAFLGKAASD TATHQRLIEL
VEGGVVLDEG ALAEQLLH
//
