ID A0A168CIQ6_9HYPO Unreviewed; 1217 AA.
AC A0A168CIQ6;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=AAL_03883 {ECO:0000313|EMBL:KZZ96654.1};
OS Moelleriella libera RCEF 2490.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Moelleriella.
OX NCBI_TaxID=1081109 {ECO:0000313|EMBL:KZZ96654.1, ECO:0000313|Proteomes:UP000078544};
RN [1] {ECO:0000313|EMBL:KZZ96654.1, ECO:0000313|Proteomes:UP000078544}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCEF 2490 {ECO:0000313|EMBL:KZZ96654.1,
RC ECO:0000313|Proteomes:UP000078544};
RX PubMed=27071652; DOI=10.1093/gbe/evw082;
RA Shang Y., Xiao G., Zheng P., Cen K., Zhan S., Wang C.;
RT "Divergent and convergent evolution of fungal pathogenicity.";
RL Genome Biol. Evol. 8:1374-1387(2016).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZZ96654.1}.
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DR EMBL; AZGY01000007; KZZ96654.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A168CIQ6; -.
DR STRING; 1081109.A0A168CIQ6; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000078544; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000078544}.
FT DOMAIN 1055..1071
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1217 AA; 135951 MW; 8CDEAB805CDB67E9 CRC64;
MAPKDADMSS AQTPARSSNK SAGLAPSSEK QRSIMSFFQK SSPGGPLSSP AARVKVSPNP
KRSSCLQETT RANTLPKPRA KPSVKLATPA PSSDAVDLPS SQENADPALG TEEKATRLAA
IEMKPDTKVP KEAASPSRKA RKVISYAESS EDDEPFNYGK LSRPRRRGRA APVMQSEDEY
DANGAASGAD NDDDMADFIA TESEDDRPKD RKRKRPSKPE VAKKRTNLSP RAHATDKTSV
LGSDDDLMDG IDAPSSASHW SYNPDSAERK PVVIPAERVA AKDSKQKEKA YTREPGDRYP
WLANIRDKEK RLPGDPDFDP RTIYIPPVAW TKFSAFEKQY WEIKQNLWDT IVFFKKGKFY
ELYENDATVG HQEFDFKMTD RVNMRMVGVP ESSLDHWVNQ FIAKQYKVAR VDQMETNLGK
EMRERQDKSG KKADKVISRQ LSCVLTAGTL VDGGMLQDDM SAYCVAIKES TVDGQPAFGI
AFVDTATGRF QISSFEDDVD LTKFETFVAQ IGPRELVLEK SRLSTKALRI LKNNTSPTTI
WTHLKPGVEF WDADTSRRAL GCGSYFSTGE DTEEVWPEVL EQHRDDDLVM SAFGALVSYL
KFLQLEKPLL SQRNFEKYNP IQKSGTLVLD GQTLMNLEVF TNSSNGSAEG SLFSLLNKCI
TPFGKRLFRQ WVAHPLCDPQ RINERLDAVD MLNADAAVRE QFASQLVKMP DLERLISRIH
AGACKPEDFV RVLEGYEQIA YTMSLLSASN EGNGLVDRLL KSMPDLEEPL TYWKGAIDRR
RAREEKILLP ERGIEPEFDE SLDTMESIKG QLNELLDKKK GDLKCRSLKF TDVGKEIYQM
EAPKSVKVPS SWRQMSSTKD VKRWYFPELS KLVRDLQEAE ELHSQLVRDI ALRLFRKFDA
DYETWLLAIK IISQLDCLVS LASASTSLGQ PACRPQFYDE DRSFVDFEEL RHPCMTNTVD
DFIPNDIQLG GKQANINLLT GANAAGKSTV LRMSCIAVIM AQIGCYVPAV SARLTPVDRI
MSRLGANDNI FAAQSTFFVE LSETKKILAE ATPRSLVILD ELGRGTSSYD GVAVAQAVLH
HVATHIGCVG FFATHYHSLA TEFENHPEIR EKRMQIHVDE QERKVTFLYK LEDGVAEGSF
GMHCAAMCGI SNRVIERAEV AAKDWEHTSR LKESLEKARS GCYIPLGILS DVGTLIGAKS
DVDERGVDVL LRAIDSL
//
