ID A0A168EFH8_9HYPO Unreviewed; 509 AA.
AC A0A168EFH8;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=sphingolipid C(9)-methyltransferase {ECO:0000256|ARBA:ARBA00039020};
DE EC=2.1.1.317 {ECO:0000256|ARBA:ARBA00039020};
GN ORFNames=AAL_03259 {ECO:0000313|EMBL:KZZ98741.1};
OS Moelleriella libera RCEF 2490.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Moelleriella.
OX NCBI_TaxID=1081109 {ECO:0000313|EMBL:KZZ98741.1, ECO:0000313|Proteomes:UP000078544};
RN [1] {ECO:0000313|EMBL:KZZ98741.1, ECO:0000313|Proteomes:UP000078544}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCEF 2490 {ECO:0000313|EMBL:KZZ98741.1,
RC ECO:0000313|Proteomes:UP000078544};
RX PubMed=27071652; DOI=10.1093/gbe/evw082;
RA Shang Y., Xiao G., Zheng P., Cen K., Zhan S., Wang C.;
RT "Divergent and convergent evolution of fungal pathogenicity.";
RL Genome Biol. Evol. 8:1374-1387(2016).
CC -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC {ECO:0000256|ARBA:ARBA00004760}.
CC -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC -!- SIMILARITY: Belongs to the CFA/CMAS family.
CC {ECO:0000256|ARBA:ARBA00010815}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZZ98741.1}.
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DR EMBL; AZGY01000005; KZZ98741.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A168EFH8; -.
DR STRING; 1081109.A0A168EFH8; -.
DR OrthoDB; 5484439at2759; -.
DR Proteomes; UP000078544; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR45197:SF1; SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED; 1.
DR PANTHER; PTHR45197; SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED; 1.
DR Pfam; PF02353; CMAS; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000078544};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 81..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 173..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 509 AA; 57529 MW; 547EDB66AB84FBA2 CRC64;
MAGKPVLESD VTYIQTPNQA PSAFDAFDCG VSVTKSKSIH NPPLPAEGAG NESFSNLLLG
SLLLGVPVFL TWLLGLGLKS WIFLTLALLF PILVAYWTFT SNFSSRINEN VRLPGRPVES
YVTFKNPADA ARWAGTSKVP MQTFSELYVD GKADFKGDTL DVMEYRHDWA KFSFTWDLFK
FIIFTFFIDV LFHTKEQDME QIRPNYDSGN DHYAWFLGPR MIYTSGIISD SSREETLEEL
QDNKMAIVCE KLELREGETL LDIGSGWGTL ATFASVNYGA QVTGITIAEN GAAWGNDVLR
KAGIPEEQSR ILCMDYRDAP KQKYNKISQL EMGEHVGIRK LTGFFRQCYD MLEDDGAMYV
QLSGLRQAWQ YEDFIWGLYL NKYIFRGADA STPLWNYVRS LESAGFEIKS VDTVGVHYSA
TLWRWYRNWV GNRNIVKAKY GQRWYRIWEL FLAWSVIASR QGSATCFQIL VVKNLNCVHR
IEGIGSQFGL SGALAKSRAA GKASLPELS
//
