ID A0A168HYC0_MUCCL Unreviewed; 931 AA.
AC A0A168HYC0;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=MUCCIDRAFT_148736 {ECO:0000313|EMBL:OAC99335.1};
OS Mucor lusitanicus CBS 277.49.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=747725 {ECO:0000313|EMBL:OAC99335.1, ECO:0000313|Proteomes:UP000077051};
RN [1] {ECO:0000313|EMBL:OAC99335.1, ECO:0000313|Proteomes:UP000077051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 277.49 {ECO:0000313|EMBL:OAC99335.1,
RC ECO:0000313|Proteomes:UP000077051};
RG DOE Joint Genome Institute;
RA Corrochano L.M., Kuo A., Marcet-Houben M., Polaino S., Salamov A.,
RA Villalobos J.M., Alvarez M.I., Avalos J., Benito E.P., Benoit I.,
RA Burger G., Camino L.P., Canovas D., Cerda-Olmedo E., Cheng J.-F.,
RA Dominguez A., Elias M., Eslava A.P., Glaser F., Grimwood J., Gutierrez G.,
RA Heitman J., Henrissat B., Iturriaga E.A., Lang B.F., Lavin J.L., Lee S.,
RA Li W., Lindquist E., Lopez-Garcia S., Luque E.M., Marcos A.T., Martin J.,
RA Mccluskey K., Medina H.R., Miralles-Duran A., Miyazaki A., Munoz-Torres E.,
RA Oguiza J.A., Ohm R., Olmedo M., Orejas M., Ortiz-Castellanos L.,
RA Pisabarro A.G., Rodriguez-Romero J., Ruiz-Herrera J., Ruiz-Vazquez R.,
RA Sanz C., Schackwitz W., Schmutz J., Shahriari M., Shelest E.,
RA Silva-Franco F., Soanes D., Syed K., Tagua V.G., Talbot N.J., Thon M.,
RA De Vries R.P., Wiebenga A., Yadav J.S., Braun E.L., Baker S., Garre V.,
RA Horwitz B., Torres-Martinez S., Idnurm A., Herrera-Estrella A.,
RA Gabaldon T., Grigoriev I.V.;
RT "Expansion of signal transduction pathways in fungi by whole-genome
RT duplication.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAC99335.1}.
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DR EMBL; AMYB01000008; OAC99335.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A168HYC0; -.
DR STRING; 747725.A0A168HYC0; -.
DR VEuPathDB; FungiDB:QYA_148736; -.
DR OrthoDB; 5100844at2759; -.
DR Proteomes; UP000077051; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000077051}.
FT DOMAIN 53..109
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 204..392
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 592..894
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 162..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..176
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 931 AA; 106424 MW; 11E55C9BF0BDFF89 CRC64;
MQSKREEQQK SIDAYRSQHV VIYTALLSEV AKEFHKRIAC STLVKDGIEY HEVFSGKEAV
DRLLSILGNN DRLEAIEIGA ALRNQNLFHD VNYEPVFIDS ADELYAFREM TNTPKDDDSS
DLPNGIYTDL TDCYSPTCTG DNLCYSWSCL KKKASTALFV HQEDDEEEEE EEKDSSNMFE
ENTRLWSQSV PENVVEATLP EERKRQECIY ELIYTEQDFV RDLQYVHEFW VEPLLSQDII
DDDKRREQFV KQVFYNIADV RHVNTELSRA LEARQAEKYL VSSIGDVMLD HVGYFHPFVE
YGAHQVIGKF TFELEKKRNP LFAQFVEETE RKPESRRLEL NGYLTKPTTR LGRYNLLLRE
ILKRTPDDNP DKETIPQIMN IITTYLEQVN VEAGKCENFF NLQQIGERLE FKSPADYVDL
KLEQPGRQLL MKGRMKRKGN SSSEASDLQV FLFDHYLVLA KIKYEDHLEK YKAFRRPIPL
ELLSINVSSS NRQKRASSIL PYSRSTNLAT MNNAAPRPST SESLATAAKS SSLSITFIHH
GRKGAPAITL FTSASSMQQI WIKKIMDQKA LLSETRSIFS IVPLIKHHFT VANRVNNTAT
IYSDNNMEQV IVGADQGVYV TKRDPATKKN IITRIITVEK VSQIELMPES QLLVLADKTL
WTFPLEILAS GASPQAKRGR SVSQNTAFFH VGECLSKTLV CVVKSNTLSA TTIRVLEPVI
MDENKKTKSL FSLKRLVRSG PVGLKAYKDL YLPSEASSIN LLKSKMCISS PREIGVVDMK
NFGVQALLDP EDEELGFVFH RPDVRPITIY RIQFGEYLVC YNEFAFFVDQ RGRFIRSKPR
IDWEGAPDSF ALSDPYVLAF EPDFIEVRNV HTVSLEQVIR GKNIRCTSTN THNTILQGAM
DDPENEGYQV VFQLEKLAKK GHSMLPSPSS Y
//
