ID A0A168K452_CORDF Unreviewed; 949 AA.
AC A0A168K452;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=isoleucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013165};
DE EC=6.1.1.5 {ECO:0000256|ARBA:ARBA00013165};
DE AltName: Full=Isoleucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00032665};
GN ORFNames=LEL_00752 {ECO:0000313|EMBL:OAA81207.1};
OS Akanthomyces lecanii RCEF 1005.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Akanthomyces;
OC Cordyceps confragosa.
OX NCBI_TaxID=1081108 {ECO:0000313|EMBL:OAA81207.1, ECO:0000313|Proteomes:UP000076881};
RN [1] {ECO:0000313|EMBL:OAA81207.1, ECO:0000313|Proteomes:UP000076881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCEF 1005 {ECO:0000313|EMBL:OAA81207.1,
RC ECO:0000313|Proteomes:UP000076881};
RX PubMed=27071652; DOI=10.1093/gbe/evw082;
RA Shang Y., Xiao G., Zheng P., Cen K., Zhan S., Wang C.;
RT "Divergent and convergent evolution of fungal pathogenicity.";
RL Genome Biol. Evol. 8:1374-1387(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAA81207.1}.
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DR EMBL; AZHF01000001; OAA81207.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A168K452; -.
DR STRING; 1081108.A0A168K452; -.
DR OrthoDB; 656at2759; -.
DR Proteomes; UP000076881; Unassembled WGS sequence.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR GO; GO:0006428; P:isoleucyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07960; Anticodon_Ia_Ile_BEm; 1.
DR Gene3D; 1.10.730.20; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR Gene3D; 1.10.10.830; Ile-tRNA synthetase CP2 domain-like; 1.
DR Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR033708; Anticodon_Ile_BEm.
DR InterPro; IPR002301; Ile-tRNA-ligase.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR NCBIfam; TIGR00392; ileS; 1.
DR PANTHER; PTHR42765:SF1; ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42765; SOLEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR PRINTS; PR00984; TRNASYNTHILE.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
PE 4: Predicted;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000313|EMBL:OAA81207.1}; ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000076881}.
FT DOMAIN 35..658
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 699..855
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..636
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 949 AA; 105795 MW; 5FEBDA0BE6D05583 CRC64;
MSKSWKSTLR LPRSTFPARP NPKLQRQHLL SCSDEFYSWQ SSRPSEDEPF VLHDGPPYAN
GPLHTGHSIN KILKDMIVRV QVQNGRHVVY RPGWDCHGLP IEMKALGAAG TKGLSAVQVR
KQARKLATKT VTEQMKGFRS FAVMSEWDNR WTTMDRAFEI RQLRVFQKMV RHGLIYRKHK
PVYWSPSSGT ALAEAELEYK DDHQSRSAYI RFPITSDYSE IPELRNFDGP LYAAIWTTTP
WTLPANKAIG VHNDLLYTVL RVNGYGLLVA SSRIDAVLEF IPEAEVVVDS ITGSKLAGLQ
YRNKLRGKSA PVQPIIHADF VSADSGTGLV HLAPGHGQDD YEICLAHDIE AFAPIDNEGR
FTAEAYPDDP EILTSAPSIL DGGSSAVLDL VAEDVIATQD IQHKYPYDWR SKKPVVIRAT
AQWFADVGSI KDDALNALKN VKFVPESGRV RLESFVKSRS EWCISRQRSW GVPIPALYNS
SGEAVMTDET IEHIIQVMQE RTSDAWFSDS PDDPAWIPAS LQGEYRRGTD TMDVWFDSGT
SWAEIEKQVD VYLEGSDQHR GWFQSSLLSY IAAQKADGKA AGGIVAPFRT LITHGFTLDA
QGKKMSKSLG NTVSPEEVMD GKLLPPAKRK GKDTGQPDAL GPDVLRLWAG SCDFTTDILI
GPTILQPVHN ALVRYRTILK MLLGSAHESS RQTPLTRLDH IALLQLSTTM EQVWEAYSNY
EFHKGVGILN RWVSTDLSAF YLEALKDRLY CGDGGGAIEP ILVGMLRMLA PVTPVLVEEA
WTNRPSWMFE DSLMVHPAKQ LYKSPVIDPK RLTYDAEKLR QDIPKLSAVH EAIKAALEPA
RLAKEVGSSL QCSVIVTTED AGLLSCLTEY QDELDAIFVV SSVSVNSALP EQPAWHYTAA
VGGDKAQGEV HVLPPVQAKC SRCWRYQAEE EEGLCERCES EVRKHEQQA
//
