ID A0A168L8S5_MUCCL Unreviewed; 4127 AA.
AC A0A168L8S5;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=MUCCIDRAFT_110092 {ECO:0000313|EMBL:OAD03238.1};
OS Mucor lusitanicus CBS 277.49.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=747725 {ECO:0000313|EMBL:OAD03238.1, ECO:0000313|Proteomes:UP000077051};
RN [1] {ECO:0000313|EMBL:OAD03238.1, ECO:0000313|Proteomes:UP000077051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 277.49 {ECO:0000313|EMBL:OAD03238.1,
RC ECO:0000313|Proteomes:UP000077051};
RG DOE Joint Genome Institute;
RA Corrochano L.M., Kuo A., Marcet-Houben M., Polaino S., Salamov A.,
RA Villalobos J.M., Alvarez M.I., Avalos J., Benito E.P., Benoit I.,
RA Burger G., Camino L.P., Canovas D., Cerda-Olmedo E., Cheng J.-F.,
RA Dominguez A., Elias M., Eslava A.P., Glaser F., Grimwood J., Gutierrez G.,
RA Heitman J., Henrissat B., Iturriaga E.A., Lang B.F., Lavin J.L., Lee S.,
RA Li W., Lindquist E., Lopez-Garcia S., Luque E.M., Marcos A.T., Martin J.,
RA Mccluskey K., Medina H.R., Miralles-Duran A., Miyazaki A., Munoz-Torres E.,
RA Oguiza J.A., Ohm R., Olmedo M., Orejas M., Ortiz-Castellanos L.,
RA Pisabarro A.G., Rodriguez-Romero J., Ruiz-Herrera J., Ruiz-Vazquez R.,
RA Sanz C., Schackwitz W., Schmutz J., Shahriari M., Shelest E.,
RA Silva-Franco F., Soanes D., Syed K., Tagua V.G., Talbot N.J., Thon M.,
RA De Vries R.P., Wiebenga A., Yadav J.S., Braun E.L., Baker S., Garre V.,
RA Horwitz B., Torres-Martinez S., Idnurm A., Herrera-Estrella A.,
RA Gabaldon T., Grigoriev I.V.;
RT "Expansion of signal transduction pathways in fungi by whole-genome
RT duplication.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAD03238.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMYB01000004; OAD03238.1; -; Genomic_DNA.
DR STRING; 747725.A0A168L8S5; -.
DR VEuPathDB; FungiDB:QYA_110092; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000077051; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000077051};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 3715..4042
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 4095..4127
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 4004..4025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4004..4021
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4127 AA; 474500 MW; F2E783E6A7C1AC11 CRC64;
MSKQLATIED LAQRLDETCT DPLVNEQIIL QIIKDLGTEL MSNLAEKNVD IVCSILFKDS
GPMYTFLSKC RIAKSGDLAA AVTKALGIMS VFVEERQKQF QKYANSLMRI AKSIAHTGGN
ASAKAAAFEV MLVLIKDSNK YDTSGFNIAD IYKTFDREYS ISGKSPTVKA KIVELLGSIA
RYHPSVIEKP TLERLKGECL KNLSVQANKT EKIEHQTSQG YLNCLNSLIC RKDVELVPKN
SSESETLFHI ILRILQSMLD TNRYGTPVAA MALFTRHARL FSNLLLPNSE NLYVCLYRWA
GHHNIEASKN GLLAFEEFIK ELSTVLYHNI QGEPELQTFF TFMARFNDIL EQADSVDDMY
KVSIAIRSVG YFAKILTKVK NADVEALRKS LVKISEWLYS ETNAKQTEYI RHLPAFIKAY
TSFAQTMNVI PENLLSTLRH MCKIFIERIP YATGYLRRSG CSNIYQLMLM LYKKGEGLGR
SFTNSLFERA LTFTATNITM PNEDPGPVYK KLLYFWKVIL DKTQYTTWGV KTENFDGDDD
NLYPDKEDKP TAHMKKELQN MLYDVFITNM MKIIQQLNLN VDVSKKKTTP RAAAAAVTPV
EEDDDTEDQA RIISNLRPVN HKDFILFQNL VDFWTTIVKD INNKRLMHWV YIFGAALIEL
SALHPLVSGF YRMLSEILVI CEKEQLFAGC EAYFTQAKQQ QLTATESPAN KPAEYVTYLV
YREYLKEVWH RLQQYTDELL ASSLRLILAY PTEFFEINEL ITPLEKALRL GITYHPLATV
AMNSLDKLLD PNLNYDIDTY FLSRILPCIN EYLLIGVVNF AEHETETKKA FKVPTAAERR
YRMVHTRATS DEIGVEKQEY ANLPELQRRM MQFLGRLGGK NKQLLAHGKD TIEDNGMLAW
DPVKKLKLRV PFLTVKVDIY LDEFLPRICE LAESSPDRQV KIAACELLHG LVIYMIGNSA
FAAKTTKAST ESLYHKYYER VFPVMLKLAI DADPIARDMY RLFYNQIIHW LTNNAHADNP
ETLALLQSLL DASCDTDAGL REYGAECIRE FVAWSIKQTS RSTDGAQNIK SLLKRLYNLM
ASSSASKRYG ASLVFNRIYR QFREERALVD EYTIEILGQL FLSLKMAEAD HPSIGTRDQI
TEAINHITRI IDKKADVFLK ENHASRRPFI GANEVIALPQ LVRWTFTEGG SLQRNYVKLC
ISFFSKFAVL LPGIKTSKQW VSQELRANSN FLVEIFETDH LKPPSMLSEE EEIHIVSIYM
NWVKRLTSTL DAYIWLIERD IVNPSDILEA HSSHLMLAIA FFIRNNPETY LEDMLNAHLA
EKSRIKSIYT YISVRLIYFF DLVFGPNGGD GCFRYVERIF SDTLYYTNFM DMIARALLLP
KDTSETIQSH QDNAITQSGV KRMFEISQRY ISTMIAKQST NFIEQLAPSI SATLISNKVD
LAMDTAKPME RSALIEMSQT VDAIKYLQSI QAWDKVCQKA TVLNAQYPSS AFAYCETLFK
NFLASCKSAQ EPLRIKLLGS MTTICFAQPG FAEAYCEEFL TFSIPAKRFA HKEKIEIFQK
FEKYVAECIT AHLDVFSALF KKYLNLSSDP EEDTYKTIHG YIMVLFEYLE TNRLSERKLV
WSMTDYLIQD KSLLQTIFTQ WSKEDQQALD VISLLKRLFG ADPTFMSRSR GKPVFSLIWD
VFVSFLRNKS FGVRLAALDL LPVFICLNEE DVKIITHELA VNYVDQLPRV QGKKYIRQGT
SEYNMIISTL DKLLVPMVTF KSVALFNLLM VTFIKESDHI HKDVMESSIE KFSKGLGLQS
FLDITKALMD FFKDPQYSIV HKKSITKVLL VLLRGANEGH VIAFFKEHLG YILGLVSQRV
DKNTALLDTL HMMANCLCFM QAFFNLISRN AHGKGKELDS VWLNCKENQN HTHVTKEILN
LFMIVHEGSK QDLTRLAPER REAIFTYHRE VVNTIGTWAM RVSNKPKAYD AVFHIDRGVY
VWNVLVDPEV PIHLDTQFAQ PLLRTKLDMF FNHKEKSKEK PHLHYNELTD ITGSSLSQQS
FSQVVLEENQ QPNDEDTDME GGATVAAAEL SEPTEEEDEA KIQQDTVDRM VDIDQLNNNT
FMPVLTEMIK TLSEVKEKDK KGNETEKSIS MPSWMMGLFR AFEHYQSPEH DKTKYIRQVY
IAKLITNYPE AFEGYAHKWI LPLLKFVVKG YLFGEPINYL VHDICIFLGV WGKTTFNTKA
DGTTPPSGFR DAVYDCLNYL MQHAHHPNPG VQRDNIDIIT KLFNNWGSQE VVPTKAIYQQ
FTHPQSDYRR NIVGLELTAL CYGHGFFAYN RERPQDLYDL PEEKFYVDMA DNLTMRGASS
SNLRIYAAEL MGWSLEIIIK DDDRKSPEKE RLYETLRDIY RQKFVDFANS KNFNLTQYFR
CINGLSIHDK DISYSILHNV SVMLYNATQE EKVEGLRFIK TCHQEGEEFN STLYSTLKQA
GLNRMFTSKD EKLQLGALKV VDTYFNDFKM DEIDSIFRMT GKVFPEHENN DCRAVYYSFV
KKTYARASAR DRIKSKTKAQ LFRGLIDKKN EIALDIFHFV TRDFGVGDNI RETLKKITGD
MYLSDTEDIY LLYATRMILE NTKKTFDFNE PIFQNSLTGS NPADGYHTFD TTWHTSSSMQ
PLFVDFQTKP KKLNLDDIEA NLKKTQSQMD FTQTVGSNES LTKTFNPASQ DGAIIIIYDD
DDDEKTDSQL LETKKETKED KYAVRRRNGG SAAALNRMYA DRYERLRKKK ETLSNYRMEA
SEKQVELTRS YREGEIPDVK ILHKDLLRPL EVLATADYNI SRLLYSSLAV SILNEMKGVS
SDQEYSAYQD EFVKMITKNL TMSELYFTPT IGSFLRIIFE LGASVPALLV KVASSKSDNH
HIGIAILENQ LLYGDHGERP AKRSSKLTPT QEKWIHLSLL YQHIDELEIF ENVYLTNVAD
NDKVRQALRY QIEGNFAVAF NSFDEALQQA GSAVDDTEYN LWQEQMLFCR TQLGQWDHIG
SDTRDALGDN WDLLWSEKED PYLEYFVRSY SKAGDERIMT GEEWREFRQA ERDKKTELQS
AGGSRKEVEL KMKQWVSEKR AWRPHEVNPI FQFLDDAYKN PAHKEKLLNR FACDWSMVEI
LRKEYNLSRL FIGRSYDALL SSWTTLHPLA HTSRLARLSQ LQRTVETEDY LELHKKIEEK
TCVRQDIHTF LRALSLRHPD SQNDRMDVWH DILWSRLEYL KDLYQPDDAS LSNELSLAKN
QFVNITEDTA IKQHNVSILP TIRKYYDDSA KYMKDINSIR YLQINFAGKN LSGKALPFEK
LLIKSFDSKV APHATRQQQC KQKLVIAASF DILKQELIAE PRLVKKALEN RKSGLPKFVA
RNHLDGIIND PNKLVNHLEV LGFNTLIEAE QFVDSQASQR ADYLWRLGRY CDESLHVLQE
DTDTIKPNID PVKYTNIVIR HYFEAMDLGH REASNYFPRL LELIELYPET GETFKACSLR
ISATWRYIRW IPQLVSSMNG PIAPYILPAI QRLAETYPNA LYYPMQISCE IYELRKNALP
KDICDAIERI MHMIKSPILE EFSNELKRLT DPYHIVKDFL AYIRSDLANK DVPQSFVASK
YNEFYQLVLN SYSERLGTIP KKQAAKFANH FIRSFGENGS KISKLTEKNV AELEQFCREK
LNTGNNPSEE KNLKSYSPWL NAFKSIEHDQ ELEIPGQYDG FSKPYPELHA KVASVDPTLL
VMHSMRRPKR IKIYGTDEKE YLFLVKGGED LRLDERIEQA FSVMNDAIKK NKFCSSQNIQ
IATYNVIPMA SSLGIIEWVD NTKPLKACME EQGSAELLVN AKRKYNRWIT SNKRASKNLA
ERYHAAFAQP RDTVVGKFKD AEASVPANLV RDYLFKLASS PEAFLFSRKE FAYSLACISI
FGYIMGIGDR HMDNFLVDMK SGRLIPIDFG YAFGVASELL PIPEIVPFRL TRQLVAVLEP
LGISGILEDA MTHILSAVQA EKELLLNIMT VFVKEPHLEW KQAAKKQSKL QKRDDEKSSS
ITSTADKTNS LDQDIAWYPQ SKINIVKRKL NKGNPASITI SEMTNGHRNK SYYKDVVAIA
RGVSGIDIRA DVGDVCKDTN EQVRCLINQA TDPRVLGVGY EGWAPFY
//
