ID A0A168N6G8_MUCCL Unreviewed; 889 AA.
AC A0A168N6G8;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=MUCCIDRAFT_138902 {ECO:0000313|EMBL:OAD05857.1};
OS Mucor lusitanicus CBS 277.49.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=747725 {ECO:0000313|EMBL:OAD05857.1, ECO:0000313|Proteomes:UP000077051};
RN [1] {ECO:0000313|EMBL:OAD05857.1, ECO:0000313|Proteomes:UP000077051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 277.49 {ECO:0000313|EMBL:OAD05857.1,
RC ECO:0000313|Proteomes:UP000077051};
RG DOE Joint Genome Institute;
RA Corrochano L.M., Kuo A., Marcet-Houben M., Polaino S., Salamov A.,
RA Villalobos J.M., Alvarez M.I., Avalos J., Benito E.P., Benoit I.,
RA Burger G., Camino L.P., Canovas D., Cerda-Olmedo E., Cheng J.-F.,
RA Dominguez A., Elias M., Eslava A.P., Glaser F., Grimwood J., Gutierrez G.,
RA Heitman J., Henrissat B., Iturriaga E.A., Lang B.F., Lavin J.L., Lee S.,
RA Li W., Lindquist E., Lopez-Garcia S., Luque E.M., Marcos A.T., Martin J.,
RA Mccluskey K., Medina H.R., Miralles-Duran A., Miyazaki A., Munoz-Torres E.,
RA Oguiza J.A., Ohm R., Olmedo M., Orejas M., Ortiz-Castellanos L.,
RA Pisabarro A.G., Rodriguez-Romero J., Ruiz-Herrera J., Ruiz-Vazquez R.,
RA Sanz C., Schackwitz W., Schmutz J., Shahriari M., Shelest E.,
RA Silva-Franco F., Soanes D., Syed K., Tagua V.G., Talbot N.J., Thon M.,
RA De Vries R.P., Wiebenga A., Yadav J.S., Braun E.L., Baker S., Garre V.,
RA Horwitz B., Torres-Martinez S., Idnurm A., Herrera-Estrella A.,
RA Gabaldon T., Grigoriev I.V.;
RT "Expansion of signal transduction pathways in fungi by whole-genome
RT duplication.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAD05857.1}.
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DR EMBL; AMYB01000002; OAD05857.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A168N6G8; -.
DR STRING; 747725.A0A168N6G8; -.
DR VEuPathDB; FungiDB:QYA_138902; -.
DR OrthoDB; 1367119at2759; -.
DR Proteomes; UP000077051; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000077051}.
FT DOMAIN 225..412
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 618..889
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 536..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 889 AA; 101899 MW; 04DDF1B3547B2BC8 CRC64;
MAQRSQSFAY GTKSATTASA TTTIAANTAT TTAVKRKSNI YSALLSKIAI ELRQRITLAD
HIKDDIEYKN TFDGKQVVDK IALIVQTSDR KLALRIGRML SAQRFFHDVS YETQLVDSSI
YLYEFTNRTF EHNVDVTNNN QIIPNGIIVD LTHCYVPTCW DLKPCYSPIC PKRFTQSSES
FSNLFVSLSS SKSTIAKSKS ALHHDYWADG VEKSIYDSLS KTERKRQENL YELIYTEKDY
VQSLEYLQNM WIKPLTERPI IPASRKETLL RKVFGGIEEI YKINIRLLQA LQERQSQHSI
IHQVGDILLD FVIEFEPYIS YGSKQYEAKF ALENERFINP NFDAFVEATE RHPDSLKLEL
NGYLTKPTTR LGRYTLLFNE ILKHTPADHP DLEDLPKAVT IIKRFLSRVN AETGKAKNRF
DLERIHYNLS FKYKADEVNL DLLAKNRSIV KQGTLKKSAQ LESVEYQVIL FDHYLVIAKL
KIINGTERYV IQKRVTSKRS STLVLPYLTM NTPNPMMAVP GAQLRASTDI GPYLHQNTNN
GSPINGSNSS SSTKPNQYPI AFQHLGRSTS APYILFAPSH ATRKPWFEKI RAQQEAKNKR
SPVFEMVSSV LEHQFIVLNK IHHFITFNGG QQYLLAADDG VYVGHHNYRH AETTPHKVLS
LEKVTQIQTI ESTETLLVLA DRTLWEYPLD IVNGKPETQP RGRLVQTHVP FFYVGTCLKR
TMVCVPKIST LRSVITVFEA VKRTDLINSN NNSSMAAIKD TYVPSEAYAV ELSASMMLIT
SSRGMIMVDM RTDQPQREEK EVSSSLNLRQ PIKRIAIFRT PRNHYFICYD EYAFYIDSKG
NRLFTKFLIE WEGTPESFAF CYPYVMAFDA SFIEIRNVIT VSAQRMLFF
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