ID A0A168NKY6_ABSGL Unreviewed; 1270 AA.
AC A0A168NKY6;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=ABSGL_06464.1 scaffold 8356 {ECO:0000313|EMBL:SAM00741.1};
OS Absidia glauca (Pin mould).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Cunninghamellaceae; Absidia.
OX NCBI_TaxID=4829 {ECO:0000313|EMBL:SAM00741.1};
RN [1] {ECO:0000313|EMBL:SAM00741.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 101.48 {ECO:0000313|EMBL:SAM00741.1};
RA Evans L.H., Alamgir A., Owens N., Weber N.D., Virtaneva K., Barbian K.,
RA Babar A., Rosenke K.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LT553414; SAM00741.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A168NKY6; -.
DR STRING; 4829.A0A168NKY6; -.
DR InParanoid; A0A168NKY6; -.
DR OMA; FAHVNDI; -.
DR OrthoDB; 5100844at2759; -.
DR Proteomes; UP000078561; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000078561}.
FT DOMAIN 512..700
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 904..1247
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 23..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 977..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..1016
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1270 AA; 142943 MW; 80E12B25DE748D88 CRC64;
MTTQSTTTRL TPSASIREQY YRKHGIQQRS TSNLNPSSNQ VDNVTSQQQQ QLRDEGEDSD
NLFDYRPEGA IAFAPLKLPD FPSINADDIS LLSRQTEYDD TEDDEAATRS IISLQTMDSL
AIGNNDSGHS TLASSSGTNS GHPLAAPAPA PAPPRSLFGQ PKSSRNFLRR QQSSQTLFAS
SSSAMDPQWP PQQQVTSSKA STNEKASLLS RLSKTTAPMR ARLSAMSRTS NYLKSEMVAS
ISIPLRRSAE SVYNFPTSTA MRITGRKTQA ERAQSFTFEK SVRPSRDLIS PNQSTSTSSK
DGAPVLYPAM LSEVAVAFKE RVTVGTKIKN SIKYKDTFDG VEAVDKLAFL TKTKDRNLAL
LLGRALDAQK FFHDVNYEHR LRDSRQELYR FTEHINVRHS QLLPSPPQND SSIAEEDDVS
EFNYPTPTND NNHPNGVFTL LLTCYSPTCS REKLCYSVFC PRRLEQQARS ANHRNQIHRS
SSKSSLVEKK DRLWTTTVPK AIVEKLSKED RKRQENIFEF IYTEKDFVDD LGYLKTYWIE
PLLTGDIIQP PERRESLVRD IFWNIMEVHE ANGRFVEALQ KRQKQNPVVD QVGDIILEYV
AHFTPFVQYG AHQIIGKSIF ETEKSTNPDF AAFVQTTERL PVSRKLELNA YLTKPTTRLG
RYSLLLREIL KHTAKDHPDQ ETIPKATKII AEHLTNVNHE TGKTENRFNL QLLAEKMQDS
SHLSDMDLDL LDENRQIVMK GPLKRKGTGS ESLALQVYLL DHCLIITKQK FVDDVEHIKL
YKKPIPIGLL AISLPDQTKR ASVILPYGQH KTSGSISSID LTSLASASNP NGTSSSGTTG
TKSGYPISFV HLGRHGANPT TLYASTFTSR RQWVDKIESY RYSVMEKQKV FEVVPINSDF
FNGFNKVNCA ATFGDSIIIG SDQGVYLSSG TKNQRKVTRL LSMDKVSQID ILENKFILVL
ADKTLYTYAM DSLLNKEGQQ QGSDDDDGGY TKTNDFDDND TTHRQTEGDG STHSRRGRKI
SSHVSFFKVG TVMDKSEGQA VERSLVCYVR YNAMTSTIRA LEVHDSSAAK NKKKKQQSIR
RKTKQLGTLL RHQHEGLRVF KDLYIPGEAT SIQYFKNVLC IGSAKGFQMV DVGSAGVLSV
LDPNDTSHAV MASKYDLRPI SMFRHPEKNI LLCYNDLAFY IDKKGQRARP DWIMRWEGNP
TAFAFRYPYI VAFDSSFIEI RHIDTGHIVQ VIPGNNIRCL KPDPLDAIHC VMEDGVSGNE
LVFQLKFIEK
//
