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Database: UniProt
Entry: A0A168P559_9BACL
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ID   A0A168P559_9BACL        Unreviewed;       456 AA.
AC   A0A168P559;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   28-MAR-2018, entry version 15.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378};
GN   ORFNames=PBAT_10200 {ECO:0000313|EMBL:OAB46393.1};
OS   Paenibacillus antarcticus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Paenibacillaceae;
OC   Paenibacillus.
OX   NCBI_TaxID=253703 {ECO:0000313|EMBL:OAB46393.1, ECO:0000313|Proteomes:UP000077355};
RN   [1] {ECO:0000313|EMBL:OAB46393.1, ECO:0000313|Proteomes:UP000077355}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CECT 5836 {ECO:0000313|EMBL:OAB46393.1,
RC   ECO:0000313|Proteomes:UP000077355};
RA   Shin S.-K., Yi H.;
RT   "Draft genome sequence of Paenibacillus antarcticus CECT 5836.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|SAAS:SAAS00723532}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723505}.
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|SAAS:SAAS00984457}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723552}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723548}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OAB46393.1}.
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DR   EMBL; LVJI01000015; OAB46393.1; -; Genomic_DNA.
DR   RefSeq; WP_068649177.1; NZ_LVJI01000015.1.
DR   EnsemblBacteria; OAB46393; OAB46393; PBAT_10200.
DR   Proteomes; UP000077355; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000077355};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|SAAS:SAAS00723549};
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723511};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723558};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723518};
KW   Reference proteome {ECO:0000313|Proteomes:UP000077355}.
FT   DOMAIN        7    102       tRNA_anti_2. {ECO:0000259|Pfam:PF13742}.
FT   DOMAIN      125    440       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
FT   COILED      266    301       {ECO:0000256|SAM:Coils}.
FT   COILED      311    331       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   456 AA;  51624 MW;  BA8ECCEE9798ED0D CRC64;
     MDQQNVLSIK DLNRYIRMKL DSDSLLSDVW IRGEISNFTH HSSGHMYFTL KDESSRIKAI
     MFGSHNQKLP FIPKEGSRVI ARGNVTVYER DGQYQFYATH MQPDGIGSLY LAYEQLKKKL
     ESEGLFASDR KRLIPDYPKT IGVITSPTGA AVRDIIITLK RRYPQVNIIL YPVLVQGKGA
     APAIVKAIEA LNIMAEVDVI IAGRGGGSLE ELWAFNEEIV ARAIYRSAIP IISAVGHETD
     FTIADFVADL RAATPTAAAE LAVPNVEEIK ATLQLRERQL RQALKQRVQH GRERLAALQR
     SPVLVHPRRT LQQHTERLDR LQLQLTRSIR SDLKLNMERK SRIHHSLLRF NPQEQVSSAK
     KNRERSQRQL QLAMLSILKG SQTQLGSAVR QLDALSPLKV MSRGYSLVYD EQEKRLIKSI
     SDVQLGDLVK IRVNDGQFDC QVWAIKEDEQ SHGEGH
//
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