ID A0A168PLM8_ABSGL Unreviewed; 275 AA.
AC A0A168PLM8;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 4 {ECO:0000256|ARBA:ARBA00020629, ECO:0000256|RuleBase:RU364141};
DE AltName: Full=Mediator complex subunit 4 {ECO:0000256|ARBA:ARBA00031257, ECO:0000256|RuleBase:RU364141};
GN Name=ABSGL_08401.1 scaffold 10128 {ECO:0000313|EMBL:SAM02598.1};
GN Synonyms=MED4 {ECO:0000256|RuleBase:RU364141};
OS Absidia glauca (Pin mould).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Cunninghamellaceae; Absidia.
OX NCBI_TaxID=4829 {ECO:0000313|EMBL:SAM02598.1};
RN [1] {ECO:0000313|EMBL:SAM02598.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 101.48 {ECO:0000313|EMBL:SAM02598.1};
RA Evans L.H., Alamgir A., Owens N., Weber N.D., Virtaneva K., Barbian K.,
RA Babar A., Rosenke K.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364141}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364141}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364141}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 4 family.
CC {ECO:0000256|ARBA:ARBA00009626, ECO:0000256|RuleBase:RU364141}.
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DR EMBL; LT553932; SAM02598.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A168PLM8; -.
DR STRING; 4829.A0A168PLM8; -.
DR InParanoid; A0A168PLM8; -.
DR OrthoDB; 1356153at2759; -.
DR Proteomes; UP000078561; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR019258; Mediator_Med4.
DR PANTHER; PTHR13208; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4; 1.
DR PANTHER; PTHR13208:SF2; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4; 1.
DR Pfam; PF10018; Med4; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364141};
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364141};
KW Reference proteome {ECO:0000313|Proteomes:UP000078561};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364141};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364141}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 80..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 231..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 143..170
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 234..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 275 AA; 31413 MW; 39E6007B81D4CD66 CRC64;
MTSSLRDQVN DLLTEYTLVS QRYFQSLIQV AEDTPLDPQQ SPEFYIQEMV KVDTQLQFAL
DQSKHEKITL PHPVLTFVNL LFTTLSLSLS LFTTLSLSLS LFTTLSLSLS LFPPVGEHQA
RQQQIIKVQD DIQDHQATLL SMVEQLNIAN QDLEQTLNGA KKELQAADYA KKANIQFTDV
LSYASKLSKY TSAPPNFDLM NRDIKVYFEK PYPDEERIRR GLLYWQHSSQ PIPEDKFESS
DNESMSDENS DTKKDEPAST EEDGPAPFWL LDLNP
//
