ID A0A170USA8_9ACTN Unreviewed; 923 AA.
AC A0A170USA8;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Histidine kinase {ECO:0000313|EMBL:GAT79815.1};
GN ORFNames=STXM2123_516 {ECO:0000313|EMBL:GAT79815.1};
OS Streptomyces sp. F-3.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1840095 {ECO:0000313|EMBL:GAT79815.1, ECO:0000313|Proteomes:UP000078145};
RN [1] {ECO:0000313|EMBL:GAT79815.1, ECO:0000313|Proteomes:UP000078145}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wang L.S., Gao P.J., Liu L., Zhang H.Q., Cheng Z., Sun X.M.;
RT "Streptomyces sp. F-3 geneom sequencing.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAT79815.1}.
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DR EMBL; BDDR01000002; GAT79815.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A170USA8; -.
DR STRING; 1840095.STXM2123_516; -.
DR OrthoDB; 118142at2; -.
DR Proteomes; UP000078145; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd16936; HATPase_RsbW-like; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR InterPro; IPR033463; sCache_3.
DR InterPro; IPR029151; Sensor-like_sf.
DR PANTHER; PTHR43156:SF2; MULTIDOMAIN REGULATORY PROTEIN RV1364C; 1.
DR PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF13581; HATPase_c_2; 1.
DR Pfam; PF13188; PAS_8; 1.
DR Pfam; PF17203; sCache_3_2; 1.
DR Pfam; PF07228; SpoIIE; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00091; PAS; 1.
DR SMART; SM00331; PP2C_SIG; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:GAT79815.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000078145};
KW Transferase {ECO:0000313|EMBL:GAT79815.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 254..294
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..482
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 923 AA; 97982 MW; 8977CF0729DC618E CRC64;
MVRLPGRTGP RSAHRFGDRR PRPAPGPGRR AREQGGRWRS AGDRAALGGR SVAGQMFLLQ
VVIVLLLVVA AVVALVLQVR HDNVQEARTR SLAVAGAFAD APGTREALAA PDPTAVLQPR
AEAARKETGV DFVVVMNTGG IRYTHPEPDR IGTKFAGALR PALNGGTVVE EVDGTIGPLV
QAVVPVEAPD GKVVGLVSAG ITIESVGGLA DRQLPVVLGA AAVGLALATA GTALVSRRLL
RQTHGLGPGE MTRMYEHHDA VLHSVREGVL IVDAGGRLLL ANDEARRLLG LPEDAEQRPV
LDLKLDPGTA GLLASGRTAT DEVHLVGDRL LAINQRPTHL DGGPSGSVAT LRDSTELRAL
SGRAEEARKH LSLLHDAGVS VGTTLDVTRT AEELVEVVVP RFADCATVDL YDAVPAGEDP
EPGSVLRRTA YGGVREDAPL HPVDGRIRFA PSSPQAHSLR TRRPVLEPRL EAAPDRRARN
PGRTEQVLKA GPHSLIAVPV RAGSLLLGLV GFWRSPGREP FDADELALAE ELVARAAVSI
DNARRYTREH TMAVALQRSL LPRSLPEQNA LEIAYRYLPA QAGVGGDWFD VLPLSGARVA
LVVGDVVGHG LYAAATMGRL RTAVSNFSAL DLPPEELLGL LDELVARIDQ DERAEGSDAP
VTGASCLYAV YDPVSRRCAV ARAGHPPPAV IAPDGGVTFP EVPAGPPLGL GGTPFETAEL
ELAEGSRLVL YTDGLVESRE QDIDTGLEQL RSALSSAGAS PEETCRAVLD ARRPYRPGDD
IALLVARTRA LGPDRVAEWD VPGDPAAVAD VRAALGRLLD RWGLQELTFT TELILSELVT
NAIRHGAEPI RVRVLRDRAL ICEVFDSSST SPHLRHAAST DEGGRGLFLV ARMSERWGTR
SLPPGKVIWA EQPLPSPDDD RTG
//
