ID A0A170V8I2_9ACTN Unreviewed; 1089 AA.
AC A0A170V8I2;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Peptide synthetase {ECO:0000313|EMBL:GAT80168.1};
GN ORFNames=STXM2123_869 {ECO:0000313|EMBL:GAT80168.1};
OS Streptomyces sp. F-3.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1840095 {ECO:0000313|EMBL:GAT80168.1, ECO:0000313|Proteomes:UP000078145};
RN [1] {ECO:0000313|EMBL:GAT80168.1, ECO:0000313|Proteomes:UP000078145}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wang L.S., Gao P.J., Liu L., Zhang H.Q., Cheng Z., Sun X.M.;
RT "Streptomyces sp. F-3 geneom sequencing.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAT80168.1}.
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DR EMBL; BDDR01000004; GAT80168.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A170V8I2; -.
DR STRING; 1840095.STXM2123_869; -.
DR Proteomes; UP000078145; Unassembled WGS sequence.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000078145}.
FT DOMAIN 755..835
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 734..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1089 AA; 117719 MW; 7E7B38F595EE13EF CRC64;
MAADREFWSK VLTAGGFTAV PRWAREPVAG AAEHEETVPA DTARAVRALA ARLDVPVSTV
LLAAHAKVLA ALSAEQDVVT GYVTGPGRGP LPCRLTVAPR SWRRLVLDVR RVEEELIAHQ
DFPVGELRRD LGLTERSYEV VLDPADAGCD LPEEAVLRVA FGERDDRLVL RLRYRTDVLD
AEAAARIGGY HLTALRLMTA DPDAGHIGRS LLSPEEVRHQ LEALAGPHRE LPPLRAHQIF
EERVREHPDA VAAVHKDRSW TYGELNARAN RLARALLARG LGREGVVAVV TERNLDWLAA
VLAVFKAGGV YLPIEPHFPA GRIATTLSRA GCRLVLTEPG STGSLDEALA TLPEKAEKLL
IEAAYAEGHA DGNPEVEVSP DQLAYIYFTS GSTGEPKGAM CEHAGMLNHL YAKIDDLGIG
PGRVVAQTAP QCFDISLWQL IAGLLVGGRT LLVEQDAITD VERFVDTLVR GRVAVAQLVP
SYLEVVVSYL EQHPRALPDL ACVSVTGEAL KRELVQRWFA LQPGIRLVNA YGLTETSDDT
NHEVMDTVPD RVLLGRPVSN VRVYVVDERL SLVPLGAPGL IAFSGVCVGR GYVNDPERTR
EAYRTDPYRP GERLYLGGDW GRWHPDGKLE FLGRRDSQVK IRGFRIEIGE IENTLLRVPG
VRDGAVVVAD LAGRSTHLIA FYTGRRLRSQ ELRRTLGASL PAYMVPSAFH WQEALPLTAN
GKIDRKALTA LAERSAPSAQ GAADGERTAG DDGGAPRTPT ERRLAAVWAE LLGLDPHTIG
RRDHFFGLGG TSLTAVKLTI ALNRAVSLKD ITRHPVLADL AARLDGTARR RPELLQPLSE
PEGGPECALV CFPYAGGNAV NFQPMASALA GGGLAVYAVD LPGHDLAAVE EPFAPLEQVV
ERVVAEIAGR GPGRVMLWGH SSGAAPALET ARRLLGRGIE VTRVFLGAQL LGTAAERRAA
IAELTQRSNA DIAAELSADS GYSELGELNA EHAEHIGAAY RHDCVSAHRY LAGALENPPA
ARLTAPVTVV VAADDANTAR FRDRWRDWEL LAEQVDLHEL ADGGHYFLRT RPAETARVVL
GAAELLASS
//
