ID   A0A171BC22_9ACTN        Unreviewed;       421 AA.
AC   A0A171BC22;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Inter-alpha-trypsin inhibitor heavy chain H5 {ECO:0000313|EMBL:GAT84458.1};
GN   ORFNames=STXM2123_5158 {ECO:0000313|EMBL:GAT84458.1};
OS   Streptomyces sp. F-3.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1840095 {ECO:0000313|EMBL:GAT84458.1, ECO:0000313|Proteomes:UP000078145};
RN   [1] {ECO:0000313|EMBL:GAT84458.1, ECO:0000313|Proteomes:UP000078145}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wang L.S., Gao P.J., Liu L., Zhang H.Q., Cheng Z., Sun X.M.;
RT   "Streptomyces sp. F-3 geneom sequencing.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAT84458.1}.
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DR   EMBL; BDDR01000045; GAT84458.1; -; Genomic_DNA.
DR   RefSeq; WP_067398588.1; NZ_BDDR01000045.1.
DR   AlphaFoldDB; A0A171BC22; -.
DR   STRING; 1840095.STXM2123_5158; -.
DR   OrthoDB; 4318225at2; -.
DR   Proteomes; UP000078145; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR   PANTHER; PTHR10579:SF43; LOW QUALITY PROTEIN: EPITHELIAL CHLORIDE CHANNEL PROTEIN-LIKE ISOFORM X1-RELATED; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078145};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           31..421
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5007905410"
FT   TRANSMEM        389..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          40..229
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   421 AA;  44666 MW;  EF6F4D4011D41AB1 CRC64;
     MITRQRLAAG VCALLAALTA SLLFPAGAVA DETDDRDAPK VELVLDVSGS MRTRDMDGES
     RMAAAKQAFN EVLDATPKEV RLGIRTLGAN YPGDDRKEGC KDTELLYPVG PLDRTEAKAA
     VATLTPTGWT PIGPALLKAA DDLEGGDGLR RIVLITDGED TCQPLDPCEV AREIAAKGIG
     LTIDTLGLVP DAKTRDQLIC IAEATGGTYT SVRHKEELSN RVGQLVDRAA DPVVTPVAVK
     GATECADAPT LKSGLYTDRQ GFGQQRWYRV DVDPGQELRA SVSVAADRAV APGYGLLVRA
     VTKSGREIVR GEAAGNGRTD VISTGLRYPK PESDEEDAPA ETVCLQVVHS FSPAAGVKTT
     PGLPLELTVD VVDGPGTSRD VASFGLGRGW WLLGALVLTG FLAGLLWGWL SRWRIAVWRT
     N
//