ID A0A172RZ94_9ACTN Unreviewed; 1165 AA.
AC A0A172RZ94;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 13-SEP-2023, entry version 28.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=SAMN02910314_00390 {ECO:0000313|EMBL:SEO50916.1};
OS Denitrobacterium detoxificans.
OC Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae;
OC Denitrobacterium.
OX NCBI_TaxID=79604 {ECO:0000313|EMBL:SEO50916.1, ECO:0000313|Proteomes:UP000182975};
RN [1] {ECO:0000313|Proteomes:UP000182975}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21843 {ECO:0000313|Proteomes:UP000182975};
RA Varghese N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; FOEC01000002; SEO50916.1; -; Genomic_DNA.
DR RefSeq; WP_066663581.1; NZ_FOEC01000002.1.
DR AlphaFoldDB; A0A172RZ94; -.
DR STRING; 79604.AAY81_07850; -.
DR KEGG; ddt:AAY81_07850; -.
DR PATRIC; fig|79604.3.peg.1577; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000182975; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000182975};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..77
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1165 AA; 130744 MW; C9E523DA1BA8A01E CRC64;
MAFVHLHNHT EYSLLDGATK VKAMVKRAAD LGMPAVAITD HGVMSGVPEL EDACMALEKE
TGQKVKPIFG CEVYFTTDDE LKKEGKPKLY HMVLLAKNNE GYHNLVNLVS ESHVDNFYYK
PRTTYAMLQK YGKGIIGTTA CIAGIVPRLL DVNQYQDAVE WVRKLSACFE PGDFYIELQN
QGITTDHGKT QTELNHQLAG IARDLGLKTI ATNDFHYLTH EDAEAQDIML CIGTGSKVDD
VDRMRFSNDQ FYMKTEEEMR AAMAEFPEAC DNTVELAEKC NVVLERDSIL PRFPVPEGET
EVSWFRKECE KGLINRYGEG KATNMEELGK MRPDVIERYE HEAGVIIQQG FPAYFLIVQE
YIMWAKNNGI GVGPGRGSAA GSIVTYAMGI TDLDPLPYGL LFERFLSVER VEMPDIDVDF
DDQHRQDVIE HVREFYGEDH ISGVITFGKL QAKNAVRDAA RVLDYPYAVG DKICKLIGGE
IGITIQQALD TNPDLKDVYE HDPDCQAVIE AAQSIEGQVR GEGVHACATI ICRDPLSDHV
PVKRDTKGGG IITQYDGHYT PELGLLKMDF LGLRTLGVIS RACANVKKRH GIEIDPGKIP
LDDPESFKLM CGGNMDGLFQ VEGNLYVTLF ARMKPRRFSD IVASIALNRP GPLQNGFVDD
YVDRVSGKKP VKYYDDRLRP ILEETYGTIV YQEQLMQISM AMSGFSAGKA DKLRKAMGKK
KLEVMKALEE DWNNGAVENG YSLEVSKKIW SDAEKFAQYA FNKSHSACYA VLVMRTAYLK
AHYPNEFMAA VLSSYLGSND KLIHYIASCN GSGIKVLPPD INESNLEFTP VDEGVRFGLA
GVRGVGEKVV EDIIAEREKG GAYTSLHDFV RRMDARSYNR KTLEALIKAG AFDSTGYTRK
QCMHFLDDTP LLENAARRQK DRNAGQISMF DMFADDEDSG FHEEVPEPDG IEWDKRTKLK
FEKDILKIYV SDHPLRPYES KLRKLSKFRI GDLAERERDI KNSTFVGMIS AAATKLTKKG
TRMATFTLED TTGHVECVCF KYEDYADAIR EDAIVKIKGK YEAGDRNQLM AFEVSLLDLG
ESEEDAPPKT LGITIQQSDF SQQNMQFLTQ ILKKYPGRDG AVLFVRQNNG QKFRAELPLT
VDARNSGLYR ELYSLFGREV WSAAS
//