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Database: UniProt
Entry: A0A172RZ94_9ACTN
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ID   A0A172RZ94_9ACTN        Unreviewed;      1165 AA.
AC   A0A172RZ94;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   13-SEP-2023, entry version 28.
DE   RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   ORFNames=SAMN02910314_00390 {ECO:0000313|EMBL:SEO50916.1};
OS   Denitrobacterium detoxificans.
OC   Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae;
OC   Denitrobacterium.
OX   NCBI_TaxID=79604 {ECO:0000313|EMBL:SEO50916.1, ECO:0000313|Proteomes:UP000182975};
RN   [1] {ECO:0000313|Proteomes:UP000182975}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21843 {ECO:0000313|Proteomes:UP000182975};
RA   Varghese N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; FOEC01000002; SEO50916.1; -; Genomic_DNA.
DR   RefSeq; WP_066663581.1; NZ_FOEC01000002.1.
DR   AlphaFoldDB; A0A172RZ94; -.
DR   STRING; 79604.AAY81_07850; -.
DR   KEGG; ddt:AAY81_07850; -.
DR   PATRIC; fig|79604.3.peg.1577; -.
DR   OrthoDB; 9803237at2; -.
DR   Proteomes; UP000182975; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd04485; DnaE_OBF; 1.
DR   CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; PHP domain-like; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Reference proteome {ECO:0000313|Proteomes:UP000182975};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          4..77
FT                   /note="Polymerase/histidinol phosphatase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00481"
SQ   SEQUENCE   1165 AA;  130744 MW;  C9E523DA1BA8A01E CRC64;
     MAFVHLHNHT EYSLLDGATK VKAMVKRAAD LGMPAVAITD HGVMSGVPEL EDACMALEKE
     TGQKVKPIFG CEVYFTTDDE LKKEGKPKLY HMVLLAKNNE GYHNLVNLVS ESHVDNFYYK
     PRTTYAMLQK YGKGIIGTTA CIAGIVPRLL DVNQYQDAVE WVRKLSACFE PGDFYIELQN
     QGITTDHGKT QTELNHQLAG IARDLGLKTI ATNDFHYLTH EDAEAQDIML CIGTGSKVDD
     VDRMRFSNDQ FYMKTEEEMR AAMAEFPEAC DNTVELAEKC NVVLERDSIL PRFPVPEGET
     EVSWFRKECE KGLINRYGEG KATNMEELGK MRPDVIERYE HEAGVIIQQG FPAYFLIVQE
     YIMWAKNNGI GVGPGRGSAA GSIVTYAMGI TDLDPLPYGL LFERFLSVER VEMPDIDVDF
     DDQHRQDVIE HVREFYGEDH ISGVITFGKL QAKNAVRDAA RVLDYPYAVG DKICKLIGGE
     IGITIQQALD TNPDLKDVYE HDPDCQAVIE AAQSIEGQVR GEGVHACATI ICRDPLSDHV
     PVKRDTKGGG IITQYDGHYT PELGLLKMDF LGLRTLGVIS RACANVKKRH GIEIDPGKIP
     LDDPESFKLM CGGNMDGLFQ VEGNLYVTLF ARMKPRRFSD IVASIALNRP GPLQNGFVDD
     YVDRVSGKKP VKYYDDRLRP ILEETYGTIV YQEQLMQISM AMSGFSAGKA DKLRKAMGKK
     KLEVMKALEE DWNNGAVENG YSLEVSKKIW SDAEKFAQYA FNKSHSACYA VLVMRTAYLK
     AHYPNEFMAA VLSSYLGSND KLIHYIASCN GSGIKVLPPD INESNLEFTP VDEGVRFGLA
     GVRGVGEKVV EDIIAEREKG GAYTSLHDFV RRMDARSYNR KTLEALIKAG AFDSTGYTRK
     QCMHFLDDTP LLENAARRQK DRNAGQISMF DMFADDEDSG FHEEVPEPDG IEWDKRTKLK
     FEKDILKIYV SDHPLRPYES KLRKLSKFRI GDLAERERDI KNSTFVGMIS AAATKLTKKG
     TRMATFTLED TTGHVECVCF KYEDYADAIR EDAIVKIKGK YEAGDRNQLM AFEVSLLDLG
     ESEEDAPPKT LGITIQQSDF SQQNMQFLTQ ILKKYPGRDG AVLFVRQNNG QKFRAELPLT
     VDARNSGLYR ELYSLFGREV WSAAS
//
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