ID A0A172T7M2_9DEIO Unreviewed; 527 AA.
AC A0A172T7M2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Peptidase S8 {ECO:0000313|EMBL:ANE42980.1};
GN ORFNames=SU48_03450 {ECO:0000313|EMBL:ANE42980.1};
OS Deinococcus puniceus.
OC Bacteria; Deinococcota; Deinococci; Deinococcales; Deinococcaceae;
OC Deinococcus.
OX NCBI_TaxID=1182568 {ECO:0000313|EMBL:ANE42980.1, ECO:0000313|Proteomes:UP000077363};
RN [1] {ECO:0000313|EMBL:ANE42980.1, ECO:0000313|Proteomes:UP000077363}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DY1 {ECO:0000313|EMBL:ANE42980.1,
RC ECO:0000313|Proteomes:UP000077363};
RA Kim M.K., Srinivasan S., Lee J.-J.;
RT "Deinococcus puniceus/DY1/ whole genome sequencing.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
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DR EMBL; CP011387; ANE42980.1; -; Genomic_DNA.
DR RefSeq; WP_064014038.1; NZ_CP011387.1.
DR AlphaFoldDB; A0A172T7M2; -.
DR STRING; 1182568.SU48_03450; -.
DR KEGG; dpu:SU48_03450; -.
DR PATRIC; fig|1182568.3.peg.722; -.
DR OrthoDB; 9798386at2; -.
DR Proteomes; UP000077363; Chromosome.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04077; Peptidases_S8_PCSK9_ProteinaseK_like; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR034193; PCSK9_ProteinaseK-like.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR010259; S8pro/Inhibitor_I9.
DR InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF05922; Inhibitor_I9; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF89260; Collagen-binding domain; 1.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000077363};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..527
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008000456"
FT DOMAIN 64..142
FT /note="Inhibitor I9"
FT /evidence="ECO:0000259|Pfam:PF05922"
FT DOMAIN 174..403
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT ACT_SITE 183
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 215
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 367
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 527 AA; 52795 MW; C349C252EB6E9A79 CRC64;
MARLTPIVSA GTLALTLLLA SCGSQPTETA LAAPDAAQAA GPDRAARIEA PLLGTANPDA
IPGQYIVVMS EGSVSGLSAQ GLSAQNAGSL IRALSLDPQG VTVQQVYTQA IEGFAGKLSA
QNLQTLRADP RVKYIEQDGV MRANATQTGA TWGLDRIDQR DLPLNGSYSY TPTGSGVTAY
IIDTGINIGH TNFGGRAVWG TNTTGDGNNS DCQGHGTHVA GTVGSATWGV AKAVKLVAVK
VLDCAGSGSN SGVIAGINWA VSNKTGPAVA NMSLGGGASQ AVDDAVNSAS SRNLVMVVAA
GNENQNACNV SPARAASAIT VGSTTRTDAR SSFSNFGSCV DIFAPGSDIT STWIGSTTAT
NTISGTSMAS PHVAGAVALL LQGTPSGSSS AITSSLISAS TPNKVTGAGT GSPNRLLFTG
TGGTTPPPTG TTTTYTGSVS NRTSSYKPGT GGFSYAGGTL KGNLSAASGT DFDLFLQKYN
GSAWADVASS EGSSSTEAIS YAAGSGTYRW EVYAYSGSGN YTLVETK
//
