ID A0A172TLV3_9BACL Unreviewed; 802 AA.
AC A0A172TLV3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:ANE47763.1};
GN ORFNames=SY83_17400 {ECO:0000313|EMBL:ANE47763.1};
OS Paenibacillus swuensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1178515 {ECO:0000313|EMBL:ANE47763.1, ECO:0000313|Proteomes:UP000076927};
RN [1] {ECO:0000313|EMBL:ANE47763.1, ECO:0000313|Proteomes:UP000076927}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DY6 {ECO:0000313|EMBL:ANE47763.1,
RC ECO:0000313|Proteomes:UP000076927};
RA Kim M.K., Srinivasan S., Lee J.-J.;
RT "Paenibacillus swuensis/DY6/whole genome sequencing.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; CP011388; ANE47763.1; -; Genomic_DNA.
DR RefSeq; WP_068608796.1; NZ_CP011388.1.
DR AlphaFoldDB; A0A172TLV3; -.
DR STRING; 1178515.SY83_17400; -.
DR KEGG; pswu:SY83_17400; -.
DR PATRIC; fig|1178515.4.peg.3503; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000076927; Chromosome.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000076927}.
FT DOMAIN 7..205
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 208..308
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 802 AA; 88461 MW; F9C36567386C1AE2 CRC64;
MSRMIRKAAV IGSGVMGSGI AAHLANVGIE TLLLDIVPNA LTPQEEAAGL NLNAPKVRNR
YALSALEKLK KTNPSPLYSS EFAGRIQPGN LEDDLNRLSE ADWIIEVIVE NLEAKQSLYQ
RIEQVWKPGT IVSSNTSGIS IKAMVQDRSD AFKEHFLGTH FFNPPRYMKL LEIIPGEKTS
PAILEFMKSF CEQKLGKGVV TAKDTPNFIA NRIGTFGLLV TLQEMQRGGF TVEEVDAVSG
PAMGRPKSAT FRTLDLVGLD TFVHVAQNVY DTVPDGSAEK EIFKVPQVLK QMVAKGWTGE
KTGQGFFKKL KSAEGTEIQS LNFDTLEYAK ARKITSASLE ASKNAKGTKD KLKALLSTPD
KYSKLAWDIL KQVLIYSADK MGEIADTVVD IDQAMKWGFN WNLGPFETWD AIGLKRSVAK
MEEEGLTVPA WVKEWIAQGH ESFYQWNEQE GKIFYYLKNE YKALEEKPEL ISLAAFKKQN
KIVKSNAGAN LIDIGDGVVC LEFASPNNAI GGDILTMIQQ SVDEVNRNWR GMVLANEGRN
FCVGANLMLL LMEAQDEEWD EVNNIIRLFQ DSMMKLRFAE KPVVAAPHKM TLGGGVEASL
PADEIIFSAE TYFGLVETGV GLIPAGGGCK EMVMRLALST DDLEIDLQPS LNKIFETIAM
GKVSASGHDT KRLGYMRPQD RVVINEDHRI YEAKRAVLRL ADDAGYQPAK PQRFRVAGDT
GKAVLQLGAY GLRQGGFISD HDLLIAGKLA HVLAGGNVPV GTVVTEQYML DLEREAFLSL
CGEPKTQARM QHMLTKGKPL RN
//
