ID   A0A172TTL2_9BACT        Unreviewed;      2036 AA.
AC   A0A172TTL2;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Alpha-2-macroglobulin {ECO:0000313|EMBL:ANE50370.1};
GN   ORFNames=SY85_07540 {ECO:0000313|EMBL:ANE50370.1};
OS   Flavisolibacter tropicus.
OC   Bacteria; Bacteroidota; Chitinophagia; Chitinophagales; Chitinophagaceae;
OC   Flavisolibacter.
OX   NCBI_TaxID=1492898 {ECO:0000313|EMBL:ANE50370.1, ECO:0000313|Proteomes:UP000077177};
RN   [1] {ECO:0000313|Proteomes:UP000077177}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LCS9 {ECO:0000313|Proteomes:UP000077177};
RA   Kim M.K., Srinivasan S., Lee J.-J.;
RT   "Flavisolibacter sp./LCS9/ whole genome sequencing.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ANE50370.1, ECO:0000313|Proteomes:UP000077177}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LCS9 {ECO:0000313|EMBL:ANE50370.1,
RC   ECO:0000313|Proteomes:UP000077177};
RX   PubMed=27259556; DOI=10.1099/ijsem.0.001207;
RA   Lee J.J., Kang M.S., Kim G.S., Lee C.S., Lim S., Lee J., Roh S.H., Kang H.,
RA   Ha J.M., Bae S., Jung H.Y., Kim M.K.;
RT   "Flavisolibacter tropicus sp. nov., isolated from tropical soil.";
RL   Int. J. Syst. Evol. Microbiol. 66:3413-3419(2016).
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000256|ARBA:ARBA00010556}.
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DR   EMBL; CP011390; ANE50370.1; -; Genomic_DNA.
DR   RefSeq; WP_066403089.1; NZ_CP011390.1.
DR   STRING; 1492898.SY85_07540; -.
DR   KEGG; fla:SY85_07540; -.
DR   PATRIC; fig|1492898.3.peg.1617; -.
DR   OrthoDB; 9767116at2; -.
DR   Proteomes; UP000077177; Chromosome.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.60.40.1930; -; 1.
DR   InterPro; IPR041246; Bact_MG10.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR   PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF17973; bMG10; 1.
DR   Pfam; PF01835; MG2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000077177};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..2036
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5008001128"
FT   DOMAIN          1255..1345
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
SQ   SEQUENCE   2036 AA;  233696 MW;  CC10109CC8F2F9CB CRC64;
     MKLIKPFLFL AIILCSASLL YAQKVKTYDA QWKKVNDLVQ KELPKSALIE VQKIYTQAKA
     EGQDAQLIKA LVYITELQAE NREDNEVVSI RELEKEVNQV KEPATSILKS LLANRYWQYF
     QQQRYQLYNR TNTVDFKKED IATWTAEDLH KKISSLYLQS LQNKPLLQST KLDNYEAILL
     KGNVRSLRPT LYDLLAHTAL NYFNNSERDI KKPAYAFEIN QREAFAPAEE YAKARFVTND
     SISLHYKALL IYQELIRFHI ADKDPSALID ADIDRLQFVY QNTVLTNKDD LYKQALEQLT
     NKWQNIPSAS QAWFLLAAYY YQSGQQYAPL KDTTNRFAIV QAKTILERII KENKDKNEGW
     TNSYNLLQEI NRPSYRFEIE RVNVPNLPFR SLITYKNVPS LYFRIIKADS STKKLMRSLY
     EDKQWDALTK TTSLRQWQQA LPATNDLQEH AAEVKIDALP VGEYVLLTAT NDNFGKQYHL
     AAQLFYVSNI SYINLNNQFF ILNRESGQPI ANAAVQVFTQ EYDYKTSSYK KQKLGEYKSD
     KNGFIEVVNK KEKQDNSYYL DIRTGSDFLN MEDPFYHTYY YDQRNEKPAT KQIFYFTDRA
     LYRPGQTIYV KGIVINKQGK ENSIATNYKT TILLRNANYE DIDSLSVTTN EFGSFTGKFN
     LPQNLLNGEF SIRDKEGNGM AEFSVEEYKR PKFYVDFEKV KETYKAGDTV TVTGFAKAYA
     GNNIDGAKVA YRVVRQPRFI YPWLTWRWWL PRAETMEIAH GITTTDKDGK FTVRFTAIPD
     KKIDRKLEPV FDYRIYTDIT DINGETRSGE NIVSAGYKSL LLSIYTPERI AADSLKTIQV
     QAKNMNGEVQ KATVTLNIAK LQPEQRLIRK RYWQQPDQYI MSKEEYIRLF PNDEYSNESD
     RTSWQKGQTI YTQTDSTRIN GAWALEKLNV KPGFYQFEFI TKDNEGQEVK DIKYVEVFDT
     KTKELAKPDY LWTVATNKDI QPGEKTSLQI GSSANDVFLV QQTDKNKEAQ NDAYTYNYTT
     LNNEKRAIEL GATEADRGGY GVSFFFVKHN RFYQYSETVS VPWSNKELDI TYSTFRDKLL
     PGSQEKWQVK ISGYKGDRAA AEVLASMYDA SLDQFKPHNW SIPSIWASYY RTGQWQGTQN
     FSAVPSQIKW VNDRDYQGFF KQYDRFFFEE DTRVYSYNRR MAVKSAAAAN SAAREKQSKA
     MPTTDSAAPA MAQRMEVVAV NGVYKDIDDV QVTDTSTSTP EGNSAIQIRK NLNETAFFFP
     DLQTDSAGNI SFSFTTPEAL TRWKLQTLAH TKELAFGSLQ KEVVTQKELM VQPNAPRFLR
     QGDRLELTAK IVNLTDKEMT GQAELQLVDA ATNTSVDGWF QNMFPNQYFT VAPGQSEVVK
     FPIEVPFTFN SALAWRVVAR SGNFSDGEEA AIPVLTNKML VTETLPLPMR GTGTKNFTFE
     KLLNTNSETL QHLNLSVEYT ANPAWYAVQA LPYLMEQECE YTEQIWNRYY ANVLAMKIVK
     DAPRVKQIME QWKTIDTAAL LSNLQKNEDL KSALLEETPW VLQAKSETQQ KKNIALLFDL
     VRMSGELKTT LQKLKEMQSE NGGFVWIKGA PEDRYMTQYI LTGVGQLKQL GAITLEGGTE
     LSSIVSKALP YLDMKLKQDY DRLIKAKANL KIQPCDPLQA QYLYMRSMLL DYSISKDVQT
     AYNYYRKQAQ TQWTKAGKNG QGMIALALHR TGDTKTPVAI LKSLKERALI SEEMGMYWKD
     NSFGFSWLWY HAPIETQSLL IEAFSEITKD TKAVDDMRTW LIKNKQTNNW HTTKATAHAC
     YAMLLQGSEW LTNEPVVTVK LGGTTVSSQD NNRTEAGTGY FKKTIEPQFI KPEMGNITVT
     VNETKHTGAS QPVNAPSWGA VYWQYFEDLD KITSAATPLK LSKKLFIEKN TDHGPVLTPV
     EEGVPVAVGD KIKVRVELRV DRDMEYVHMK DMRASGLEPV NVLSGYKWQG GLGYYETTKD
     ASTNFFFPYL QKGTYVFEYP LFVSHTGNFS NGITTIQCLY APEFSAHSEG VRLTVE
//