ID A0A172URA2_9MYCO Unreviewed; 1746 AA.
AC A0A172URA2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=A7U43_21825 {ECO:0000313|EMBL:ANE81575.1};
OS Mycobacterium adipatum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1682113 {ECO:0000313|EMBL:ANE81575.1, ECO:0000313|Proteomes:UP000077143};
RN [1] {ECO:0000313|EMBL:ANE81575.1, ECO:0000313|Proteomes:UP000077143}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YC-RL4 {ECO:0000313|EMBL:ANE81575.1,
RC ECO:0000313|Proteomes:UP000077143};
RA Ren L., Fan S., Ruth N., Jia Y., Wang J., Qiao C.;
RT "Complete genome sequence of a phthalic acid esters degrading Mycobacterium
RT sp. YC-RL4.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
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DR EMBL; CP015596; ANE81575.1; -; Genomic_DNA.
DR STRING; 1682113.A7U43_21825; -.
DR KEGG; madi:A7U43_21825; -.
DR OrthoDB; 9760034at2; -.
DR Proteomes; UP000077143; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProt.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR CDD; cd06127; DEDDh; 1.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00479; EXOIII; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ANE81575.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000077143}.
FT DOMAIN 321..605
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT DOMAIN 1072..1246
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1273..1419
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 70..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1746 AA; 192224 MW; 019BBA98103CAD6F CRC64;
MTTSTRPMPP AAEAAHQALS EFGPLAASEL REKLRPRGFV QPIERLQQLA DRFPHRFQVN
PDGLLAVATT SATSRDDDPD RAPGDDVDWY RPHPDRIPLD RVAVLDLETT GLNRATDFIT
EIAVVRLDGT PLLDVAIELP PGIDRPAPAR SEPVPLGEAL RRFETDIADI GLLIGHNIVN
FDQKFLIAAA NRAGLHPPRL PPIIDTLHLS LLVDVALPNR GLADLTQMLN VDHSARHQAL
SDATATAAVS RKLIASVDAT EPSWALAIAA LETHSHPLAL IMPPLSSVPE LTTLTRDADA
LLTPTGSASP DAWSATRNAF PVLHRQRGLR SRPAQQEMAH AVAQVFDNGG RVAVEAPTGT
GKSLAYLLPA IGRASRPRQP VLLATATKAL QSQLRDEAAR LQQENLLAAP FRQIQGVGNY
VCARELEDAL PDVDASGLAL AVAVRALATS PTGTWDDVTD DVVRRADTRY ARTRARIKTS
SGGCDRTSCK WASLCPLMRQ IQGLDSSPGI VSVNHALIAS WIKLAQSGIP APGDVLGEGR
ADLVLDEAHA LEDSLTAAWT EGIDALELEI LVNSLSRRSR LVREIQKRAP GRTDVVDALQ
AIAATLPQIR PAGTELSEAI ATYLHEYAGR ADAVVLRSGV VDGRPEFRIL RQAARQVRYQ
LIQLAKAVSS LRSSLSDVAG TGSARQRLRG YAERLDNAIN LLETLGPLPD SHLWVYRLAA
EEDDPAAWTY ERLPIHIFPE FKQWVVDRTH STVLCSATLT VEHRFDYTAS RLGVRIDPEP
GDDDFRALRL ASPFDYQNQS VVVLTNHLPV PIPVNEREFC EEMAADQAGF LSLAGGRTLT
LFAARKRMDA VADGVRTKTA ELAQRGVELL VQGELGRSQI AHRFRNEQGT VLYGLKSYWE
GFDAPGETLS YLFIEKPPYP HPDDPLVSAR QRAIAERGGD PFLDYVLPMT AMQFTQGFGR
LIRSETDKGA ALICDRRLHA PTQAQRVMLG SLPGPAIHES QDRDDAWTRA IEFVTGEAPD
LSTAISFGRD DVTQLLESLR LIEGEDPTAK LIEAAEKLFG IAELHPKQLE VMQAIIDGRD
VVAILPTGFG KSVCFQLPAL LAPQARATVV VSPLVALIKD QVNDLRGRRG IRPVQGITGT
TSRVVQTEIL RDTAKGDVRL LYVSPERLAR DPVLRGALGR QQLNRVIVDE AHCISVWGHD
FRPEFRQVPA SVASFDTRPP RAGLTATATP DVEVDITGAL DMVEPVSVRE PSDRQNLRFR
VVHCADERDR ARELLRFVTW CAGVPGIVYV SKRALAEEIA ALLRRAGYSA RPYHAGMVPE
QRDAVQEDFD SDTTQIIVAT KAFGMGINKP NIGWVLHYDL TDSLDGYAQE AGRAARSRDL
TGNCVLLYTN SDLARRRRLI EANSTKADAA ITQRLLALLW TCTERRDSRV FDIDEVADQL
GIDDDEVNVH LAQLERVGAL EQELDCSARG TVDVGFREPE DERERTLFRE LFYRAHRARP
NVRIQIDFQQ LKDAHGYDPD DLERQLIDWS LDRLVTFSSS RRLRRVRLLK RVAPEDVLAR
ESARWKWWQK RRLQAMIDYA TNESDCRRII VGRHFGDEIA DCGSRDIVTC DICEGTPAPW
ASTPDHLVPD PELLVNAELT ALQAIAWSSS YRRGAYGEAS LKAAVLGRES LGEGRPLGAG
VLSCPQFGAL RHVRNGERRW DETVHNLLDK GLIERRAVER EATRTAYQSL ALTALGAQTL
GVPGAQ
//
