ID A0A172WDW4_BUCSC Unreviewed; 495 AA.
AC A0A172WDW4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Transcription termination/antitermination protein NusA {ECO:0000256|HAMAP-Rule:MF_00945};
GN Name=nusA {ECO:0000256|HAMAP-Rule:MF_00945,
GN ECO:0000313|EMBL:ANF17115.1};
GN ORFNames=XW81_01735 {ECO:0000313|EMBL:ANF17115.1};
OS Buchnera aphidicola subsp. Schlechtendalia chinensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Buchnera.
OX NCBI_TaxID=118110 {ECO:0000313|EMBL:ANF17115.1, ECO:0000313|Proteomes:UP000077654};
RN [1] {ECO:0000313|EMBL:ANF17115.1, ECO:0000313|Proteomes:UP000077654}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC {ECO:0000313|EMBL:ANF17115.1,
RC ECO:0000313|Proteomes:UP000077654};
RA Zhang Y.;
RT "Buchnera aphidicola assembly.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in both transcription termination and
CC antitermination. {ECO:0000256|HAMAP-Rule:MF_00945}.
CC -!- SUBUNIT: Monomer. Binds directly to the core enzyme of the DNA-
CC dependent RNA polymerase and to nascent RNA. {ECO:0000256|HAMAP-
CC Rule:MF_00945}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00945}.
CC -!- SIMILARITY: Belongs to the NusA family. {ECO:0000256|HAMAP-
CC Rule:MF_00945}.
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DR EMBL; CP011299; ANF17115.1; -; Genomic_DNA.
DR RefSeq; WP_075474237.1; NZ_CP011299.1.
DR AlphaFoldDB; A0A172WDW4; -.
DR STRING; 118110.XW81_01735; -.
DR PATRIC; fig|118110.3.peg.350; -.
DR OrthoDB; 9807233at2; -.
DR Proteomes; UP000077654; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006353; P:DNA-templated transcription termination; IEA:UniProtKB-UniRule.
DR GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-UniRule.
DR CDD; cd02134; KH-II_NusA_rpt1; 1.
DR CDD; cd22529; KH-II_NusA_rpt2; 1.
DR CDD; cd04455; S1_NusA; 1.
DR Gene3D; 3.30.300.20; -; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.30.1480.10; NusA, N-terminal domain; 1.
DR HAMAP; MF_00945_B; NusA_B; 1.
DR InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR025249; KH_dom_NusA-like.
DR InterPro; IPR009019; KH_sf_prok-type.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR030842; NusA_bac.
DR InterPro; IPR036555; NusA_N_sf.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR013735; TF_NusA_N.
DR InterPro; IPR010214; Tscrpt_termin_fac_NusA_C_rpt.
DR InterPro; IPR010213; Tscrpt_termination_fac_NusA.
DR NCBIfam; TIGR01953; NusA; 1.
DR NCBIfam; TIGR01954; nusA_Cterm_rpt; 2.
DR PANTHER; PTHR22648; TRANSCRIPTION TERMINATION FACTOR NUSA; 1.
DR PANTHER; PTHR22648:SF0; TRANSCRIPTION TERMINATION_ANTITERMINATION PROTEIN NUSA; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF13184; KH_5; 1.
DR Pfam; PF08529; NusA_N; 1.
DR SMART; SM00322; KH; 2.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF54814; Prokaryotic type KH domain (KH-domain type II); 2.
DR SUPFAM; SSF47794; Rad51 N-terminal domain-like; 2.
DR SUPFAM; SSF69705; Transcription factor NusA, N-terminal domain; 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00945};
KW Elongation factor {ECO:0000313|EMBL:ANF17115.1};
KW Protein biosynthesis {ECO:0000313|EMBL:ANF17115.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000077654};
KW Repeat {ECO:0000256|HAMAP-Rule:MF_00945};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00945};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00945};
KW Transcription antitermination {ECO:0000256|ARBA:ARBA00022814,
KW ECO:0000256|HAMAP-Rule:MF_00945};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00945};
KW Transcription termination {ECO:0000256|ARBA:ARBA00022472,
KW ECO:0000256|HAMAP-Rule:MF_00945}.
FT DOMAIN 135..200
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
SQ SEQUENCE 495 AA; 56018 MW; D66F34F0A7D90173 CRC64;
MNKEVLAVVE AVSNEKSLPR EKIFEALESA LAIATKKKYN QDIDIQVKIN RKNGNFKTFR
RWLVVKEVLN PTKEITFEAA KYENELIKIN DYVEDVLESV TFDRITTQTA KQVIVQKVRE
AERSMVVNQF KSHIGEIVTG IVKKNNRDSV TLDLGNNAEA LILKEEMLPR ENFRIGDRIK
GVLYSIRPES RGAQLFVSRS RPEMLIELFR IEVPEIGEEI IEIKAAARDP GSRSKIAVKS
NDKRIDPVGA CVGMRGARVQ AVSNELCGER IDVVLWDSNS AQFVINSMAP ADISSIVVDE
ESHSIDVAVH SEHLAQAIGR NGQNVRLASQ LSSWEINVMT TDDLKLKHQK EADKILSIFK
KYLKVDEKFL KILVKEGFSS IEELVYVPFN ELLNINGFRE ELAFLIRSEA KKALISIEQE
NKKNLDKKKP RQELLNLSGM NQVIAEKLAK KNIYSLEELA DQGIDDLVDI EELNVDTAGA
LIMKARNICW FGEKV
//
