ID A0A172XUL4_9FLAO Unreviewed; 676 AA.
AC A0A172XUL4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Beta-lactamase {ECO:0000256|ARBA:ARBA00012865, ECO:0000256|RuleBase:RU361140};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865, ECO:0000256|RuleBase:RU361140};
GN ORFNames=A0O34_08415 {ECO:0000313|EMBL:ANF50542.1};
OS Chryseobacterium glaciei.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Chryseobacterium group; Chryseobacterium.
OX NCBI_TaxID=1685010 {ECO:0000313|EMBL:ANF50542.1, ECO:0000313|Proteomes:UP000077824};
RN [1] {ECO:0000313|EMBL:ANF50542.1, ECO:0000313|Proteomes:UP000077824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IHBB 10212 {ECO:0000313|EMBL:ANF50542.1,
RC ECO:0000313|Proteomes:UP000077824};
RA Pal M., Swarnkar M.K., Kaushal K., Chhibber S., Singh A.K., Gulati A.;
RT "Complete Genome Sequence of Chryseobacterium sp. IHBB 10212.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|RuleBase:RU361140};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the class-D beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00007898, ECO:0000256|RuleBase:RU361140}.
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DR EMBL; CP015199; ANF50542.1; -; Genomic_DNA.
DR RefSeq; WP_066753696.1; NZ_CP015199.1.
DR AlphaFoldDB; A0A172XUL4; -.
DR STRING; 1685010.A0O34_08415; -.
DR KEGG; chh:A0O34_08415; -.
DR OrthoDB; 9766847at2; -.
DR Proteomes; UP000077824; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0017001; P:antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 2.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR002137; Beta-lactam_class-D_AS.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR PROSITE; PS00337; BETA_LACTAMASE_D; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|RuleBase:RU361140};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|RuleBase:RU361140};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transferase {ECO:0000313|EMBL:ANF50542.1}.
FT DOMAIN 49..210
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 254..583
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT COILED 643..670
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 676 AA; 75648 MW; 2EE13A29B86DBDBC CRC64;
MNTRYLKIFS ALAVIALIFV ARLAYLQLFT DRYALNAANT SIKTEYVIPQ RGVIFDRNGK
IMVGNQPAYE ISFTQALMKP DFDTLAFCSL MKIDKNDFIK RINIIKKEKY YSKLTPMTFL
KDLSREDIAR VQEIIFKYPA FSIVSRPQRQ YEVSTSGNLL GYTSEVNERD IKKDSTYYLP
GDFAGKSGVE KSYEKELRGI KGIKYIQKDI RLRNIGSYKD GTLDKDVVTG KDITLTIDYD
LQRMAEEMLV NKHGAIVAID PNNGEILTLA TGPDIDPNVF TGPNKSRNLY ALSKDTLYEN
KPTFDRSLQA AYPPGSTFKL LTALSAMQMG VMDENTIFPC GGGFNYRGLR IKGHGGADPL
IPAIQISSNC YFSYAYLAIM NKYPGNPSKG VDEWKKILNS FGVGEFLNND LAVGAKGRIP
SGEFYEKRMQ SIYKASGAKK DPKNWDALAT GAVFNGMGQG DVLVTPLQLA NYVGAIANKG
WYYTPHIVKA IDGKPNPDKR FKTKHKTLVD PKHFEPVLKG MEAVVLRGTA RGLKSNDFTQ
LAKTGTAQVP QGKDNSIFVL IAPADKPKIV VVAVMEHAGF GATWAGPACT VIAEKYITGD
LKRENLYKKM ITSSFMPEYK RQWVADLKRK GLYVDPKPDS VKLKKIQDSL NFIKEQKVKL
QKKIDEETKN IKTTKQ
//
