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Database: UniProt
Entry: A0A172YRY9_9GAMM
LinkDB: A0A172YRY9_9GAMM
Original site: A0A172YRY9_9GAMM 
ID   A0A172YRY9_9GAMM        Unreviewed;       388 AA.
AC   A0A172YRY9;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   18-SEP-2019, entry version 20.
DE   RecName: Full=UDP-glucose 6-dehydrogenase {ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.22 {ECO:0000256|PIRNR:PIRNR000124};
GN   ORFNames=A3K93_12275 {ECO:0000313|EMBL:ANF82888.1};
OS   Acinetobacter sp. NCu2D-2.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Moraxellaceae; Acinetobacter.
OX   NCBI_TaxID=1608473 {ECO:0000313|EMBL:ANF82888.1, ECO:0000313|Proteomes:UP000186584};
RN   [1] {ECO:0000313|Proteomes:UP000186584}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCu2D-2 {ECO:0000313|Proteomes:UP000186584};
RA   Wilharm G.;
RT   "Acinetobacter strain NCu2D-2 is the representative of a novel
RT   species.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH +
CC         UDP-alpha-D-glucuronate; Xref=Rhea:RHEA:23596,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885;
CC         EC=1.1.1.22; Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
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DR   EMBL; CP015594; ANF82888.1; -; Genomic_DNA.
DR   RefSeq; WP_067731469.1; NZ_CP015594.1.
DR   OrthoDB; 647136at2; -.
DR   BioCyc; GCF_001647675:G1ETL-2447-MONOMER; -.
DR   Proteomes; UP000186584; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028357; UDPglc_DH_bac.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500134; UDPglc_DH_bac; 2.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000186584};
KW   NAD {ECO:0000256|PIRNR:PIRNR000124, ECO:0000256|PIRSR:PIRSR500134-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000124};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186584}.
FT   DOMAIN      300    387       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   ACT_SITE    253    253       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500134-1}.
FT   BINDING      30     30       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      35     35       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      83     83       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     118    118       NAD; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     145    145       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     256    256       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     314    314       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
SQ   SEQUENCE   388 AA;  43845 MW;  A07AFBB6E4CD347A CRC64;
     MLKLTVVGTG YVGLSNAMLF SQHHQVVALD IDEHRVNLLQ QKKSPIQDTL IEEYLLKDIN
     FEATLDKTKA YQNSDYIIIA TPTNYDEQTN YFDTSSIEQV LNDLNLLDTS AIIIIKSTIP
     VGFTKRVQEL FPNLKIVFSP EFLREGKALF DNLYPSRIVV GDKSEVGQKI AELFKSASLK
     PEVDIALMDS TEAEAVKLFS NTYLAMRVAY FNELDSYCAL RGLNSKDIIQ AVGLDPRIGT
     HYNNPSFGYG GYCLPKDTKQ LLANYQDVPQ SLISAIIQSN TTRKDFIADE ILKREPKVVG
     IYRLVMKAGS DNFRQSAIQG IMKRLKAKGI EVIIFEPNLA QDDFYNSKVL KDFTEFKRRA
     DVIVANRMVS DLDDVLDKVF TRDLFGDN
//
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