ID A0A172ZHB8_9BACL Unreviewed; 2348 AA.
AC A0A172ZHB8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:ANF97034.1};
GN ORFNames=AR543_14160 {ECO:0000313|EMBL:ANF97034.1};
OS Paenibacillus bovis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1616788 {ECO:0000313|EMBL:ANF97034.1, ECO:0000313|Proteomes:UP000078148};
RN [1] {ECO:0000313|Proteomes:UP000078148}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BD3526 {ECO:0000313|Proteomes:UP000078148};
RA Wu Z., Gao C., Liu Z., Zheng H.;
RT "Genome of Paenibacillus bovis sp. nov.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ANF97034.1, ECO:0000313|Proteomes:UP000078148}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BD3526 {ECO:0000313|EMBL:ANF97034.1,
RC ECO:0000313|Proteomes:UP000078148};
RX PubMed=26769366; DOI=10.1099/ijsem.0.000900;
RA Gao C., Han J., Liu Z., Xu X., Hang F., Wu Z.;
RT "Paenibacillus bovis sp. nov., isolated from raw yak (Bos grunniens)
RT milk.";
RL Int. J. Syst. Evol. Microbiol. 66:1413-1418(2016).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; CP013023; ANF97034.1; -; Genomic_DNA.
DR RefSeq; WP_060535147.1; NZ_CP013023.1.
DR STRING; 1616788.AR543_14160; -.
DR KEGG; pbv:AR543_14160; -.
DR OrthoDB; 9765680at2; -.
DR Proteomes; UP000078148; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd12117; A_NRPS_Srf_like; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR CDD; cd05235; SDR_e1; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR010080; Thioester_reductase-like_dom.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR NCBIfam; TIGR01746; Thioester-redct; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 3.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Reference proteome {ECO:0000313|Proteomes:UP000078148}.
FT DOMAIN 823..898
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1864..1940
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2348 AA; 265405 MW; 47F856D815A39CC4 CRC64;
MANKDNNPGN KNDSRQFWQD YLKGITETSI LPQRLITIGP AQDTYTSVPQ QQEQISCSMA
QELTDSLIEY ASSSGIALTT LLQAIWGIVL QKYNNSDDAV FGVMCSDSDQ KHGYIEGHGY
TEKNEYPAAP LRSILPVRVT TSRTTTFQEL CLEIQRAGSL MRSYPFHTLT ELQQLADLSH
PLVDHVLVFE QGASDDACLA DSRADLASSA FVSSAQELMD TRSYTASDRN GDLKLHLDRD
LDLDRNWDWE NDQPRFVIRI SLKQTLHISL TYDPAVYDRD RMQPVCQHIV QIAEAVMQHP
NVPVHTLSML TAAERHQLIH TFHAQATEMP LPAHQTIHEQ FEECFRQYPD AVAVIFNGQS
LTYRQLNARA NQLARVLRRR GAGPEQIIGI MAHHSLEMFV GVLGIIKSGA AYLPIDPSYP
VQRTAYMLED SRTALLLIQP GLPIPDSYTG ATILLDASVW AEEEDHNIEP LHDVHHLAYV
IYTSGSTGQP KGVMIEHRAL INLCSWHNHT FHTSPADRST KLAGFGFDAS VWEMFPPLLA
GMTVHIIEER MRGDIYALQS YFAAHEITIA FLPTQLAVQF MELDHPGLRL LLIGGERIQQ
FKPQSYQVVN NYGPTENTVV TTSGVLDSFS PVLAIGKPVS NHQIWILDHA GQMQPIGVPG
ELCVSGNGLA RGYLHRPELT AERFTPHPLF PEERIYHTGD LACWLPDGQI EYKGRQDEQV
KIRGYRIEPG EIDVRLMQHP AVRESLTIAR QDQEGYAYLC AYIVSDNTWT MNELREHILH
TLPEYMIPAH FIQIDQLPLT ANGKVNKSAL PEPPAYSSAS FVAPATDNEI ALAAMFEEIL
GVPQIGVHDH FFEKGGHSLK AMTLVSRIHR EMNIDIPLNE VFLKPTVQEL AASIDTAEQS
LFYSIPRAPK QTYYPVSSAQ RRMYMVQHIQ DTATTAYNIP LLFEMKGQLD IPRLNTALQK
LIQRHESLRT SFHMIHGQLM QHIHEDISWN MEISETIAAD QQRVLLSFIR PFHLSEAPLM
RAGLFRLAHD HYLLLLDMHH IISDGVSTSI LFEDLLKLYQ GEVLPSLPLQ YKDYAVWQQS
EPGRLKWQEH KRYWLHQLQG ELPVIELPAD YPRPAVQDYR GDVWKFQLDE ELNRKIQQLC
LGQGVTLHML LLAAFHLLLS KYTNQHDMIT GAPIAGRSHA DIQSIPGMFV NMLAMRTSPE
SDLPFTDYLA QCKEMIVHAY THSDYPFEEL VEQLGLQRDA SRHPLFDVLF AVQNFTRPEF
QLPNLDILSV EPGWNPSKFS MNWTVQEGET LDIAIEYSTS LFRDSTIVQM AEHYTELLRQ
IVAHPQRSNG ELNMLSPAEY EQLTITFNQT AASYPGDQCI QELFEQQCRL HPERPAIIMG
EQQLTYAELN RQANQLAHAL IRRGSQRNPD HTPIIGLITD RSPDMIIAIL AILKAGAAYL
PIDPTHPAER ILRMLSDSEA ACVLVQHRQL WADSDRYEGE VLYLSDQPGQ TEPVYAPPVT
ARPEHPAYVM YTSGSTGQPK GVIVTHRNIV KTVINNGFLD ITPQDRILQL SNYAFDGSTF
DLYGTLLHGA ALVLVTREQL LHPVALIDYM RSQQISVALM TVALFNTLVE VNLEGLTGLR
KLLFGGEQAS RTHVDKAVRT LGEGVLINVY GPTEATVCAA VWPVDRMLLE HGQLPIGRPI
HNTSLYILNA AGQPQPIGIT GELWIGGEGV SMGYLRRPEL TAERFVDNPW IPGTLMYRSG
DLARWLPDGN IDYQGRIDEQ VKIRGNRIEL GEIEAALLEY PSIQETVVIA LQKDHSYSSL
CAYIVTDAAW TTSELRAHLG VRIPDYMIPS RFISLDQLPL TPNGKVDKRA LPVPHIDEDR
ERVAPRTDTE NNLIRLVAEV MEMQPEQISM NDNLFNIGGH SLSILKIIGK AHTIGWKLEM
KEFYIYRSFA ELAHKIDAGE SLPPEAVEPS TFTPGIPVPV PAMSIQKRSN APQSILLLGA
TGFLGIHILH ELLSTATARI TCLIRGENEQ QARERLNGKL QFYFASRYGQ HTIDHWMSRI
HVRHGDMTEH RWGMDDRDMQ KLGESVEAVI HTAALVKHYG FYEEFERVNV QGTRYAAEFC
RDFHLPLHYV STLSVSGSYA PESRENLIFT EKDLYIGQDY QSNVYLRSKF EAEALLIEEM
RSGLDVSIYR VGNLTGRYTD GQFQENIQEN MFYLSLKALA MLGGAEPAIM QERVDLTPVD
ICAAAIVRLM HTPDIQDYVF HLHNPHDVSY GEICAIWTEY GFRQTAMSRE EMKIQQQKLQ
STDQMLAGIV TTLFESTEPV NIRIDVQHTL SVLNNIGFTY PVPDKEYFRK MIHYAVQSGF
MYSESSIC
//
