ID A0A172ZN45_9BACL Unreviewed; 301 AA.
AC A0A172ZN45;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=High-affinity heme uptake system protein IsdE {ECO:0000256|ARBA:ARBA00015862};
DE AltName: Full=Iron-regulated surface determinant protein E {ECO:0000256|ARBA:ARBA00031463};
DE AltName: Full=Staphylococcal iron-regulated protein F {ECO:0000256|ARBA:ARBA00031148};
GN ORFNames=AR543_21240 {ECO:0000313|EMBL:ANF98942.1};
OS Paenibacillus bovis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1616788 {ECO:0000313|EMBL:ANF98942.1, ECO:0000313|Proteomes:UP000078148};
RN [1] {ECO:0000313|Proteomes:UP000078148}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BD3526 {ECO:0000313|Proteomes:UP000078148};
RA Wu Z., Gao C., Liu Z., Zheng H.;
RT "Genome of Paenibacillus bovis sp. nov.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ANF98942.1, ECO:0000313|Proteomes:UP000078148}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BD3526 {ECO:0000313|EMBL:ANF98942.1,
RC ECO:0000313|Proteomes:UP000078148};
RX PubMed=26769366; DOI=10.1099/ijsem.0.000900;
RA Gao C., Han J., Liu Z., Xu X., Hang F., Wu Z.;
RT "Paenibacillus bovis sp. nov., isolated from raw yak (Bos grunniens)
RT milk.";
RL Int. J. Syst. Evol. Microbiol. 66:1413-1418(2016).
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein 8 family.
CC {ECO:0000256|ARBA:ARBA00008814}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP013023; ANF98942.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A172ZN45; -.
DR STRING; 1616788.AR543_21240; -.
DR KEGG; pbv:AR543_21240; -.
DR OrthoDB; 66025at2; -.
DR Proteomes; UP000078148; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0015886; P:heme transport; IEA:InterPro.
DR Gene3D; 3.40.50.1980; Nitrogenase molybdenum iron protein domain; 2.
DR InterPro; IPR019957; ABC_transptr_haem-bd_IsdE.
DR InterPro; IPR002491; ABC_transptr_periplasmic_BD.
DR NCBIfam; TIGR03659; IsdE; 1.
DR PANTHER; PTHR30535:SF36; HIGH-AFFINITY HEME UPTAKE SYSTEM PROTEIN ISDE; 1.
DR PANTHER; PTHR30535; VITAMIN B12-BINDING PROTEIN; 1.
DR Pfam; PF01497; Peripla_BP_2; 1.
DR SUPFAM; SSF53807; Helical backbone' metal receptor; 1.
DR PROSITE; PS50983; FE_B12_PBP; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000078148};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..301
FT /note="High-affinity heme uptake system protein IsdE"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008006052"
FT DOMAIN 46..301
FT /note="Fe/B12 periplasmic-binding"
FT /evidence="ECO:0000259|PROSITE:PS50983"
SQ SEQUENCE 301 AA; 32944 MW; FD3F9C1184181E1F CRC64;
MSWKSSRPVI LLLVFIFILS GCSSSAGTMT TSAAPQANAD AQDPARIVAT TVAITEIANA
LELDLVGKPT SSKSLPDRYA SVPDVGNPMS PDMEKVLSLQ PTDILSVTTL KYDLEPKFKD
MSVNAEFLNL ESLGNMEKEI RKLGERFDRT KQADQVITKL QDKVKHIQQQ VKGKSSPKVL
ILLGVPGSYL VATENSYIGD LVRIAGGTNV VQGESVEYLA SNTEYLQQSN PDIILRAAHG
MPEEVVKMFD EEFKTNDIWK HFNAVQKGHV YDLPEPLFGT TASLNADAAL DELVKMLYPA
I
//
