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Database: UniProt
Entry: A0A173E025_9CHLA
LinkDB: A0A173E025_9CHLA
Original site: A0A173E025_9CHLA 
ID   A0A173E025_9CHLA        Unreviewed;       208 AA.
AC   A0A173E025;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   11-DEC-2019, entry version 18.
DE   RecName: Full=Thymidylate kinase {ECO:0000256|HAMAP-Rule:MF_00165};
DE            EC=2.7.4.9 {ECO:0000256|HAMAP-Rule:MF_00165};
DE   AltName: Full=dTMP kinase {ECO:0000256|HAMAP-Rule:MF_00165};
GN   Name=tmk {ECO:0000256|HAMAP-Rule:MF_00165};
GN   ORFNames=M787_004285 {ECO:0000313|EMBL:ANG66527.1};
OS   Chlamydia gallinacea 08-1274/3.
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=1143323 {ECO:0000313|EMBL:ANG66527.1, ECO:0000313|Proteomes:UP000019147};
RN   [1] {ECO:0000313|EMBL:ANG66527.1, ECO:0000313|Proteomes:UP000019147}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=08-1274/3 {ECO:0000313|EMBL:ANG66527.1,
RC   ECO:0000313|Proteomes:UP000019147};
RX   PubMed=24461712; DOI=10.1016/j.syapm.2013.12.004;
RA   Sachse K., Laroucau K., Riege K., Wehner S., Dilcher M., Creasy H.H.,
RA   Weidmann M., Myers G., Vorimore F., Vicari N., Magnino S.,
RA   Liebler-Tenorio E., Ruettger A., Bavoil P.M., Hufert F.T.,
RA   Rossello-Mora R., Marz M.;
RT   "Evidence for the existence of two new members of the family Chlamydiaceae
RT   and proposal of Chlamydia avium sp. nov. and Chlamydia gallinacea sp.
RT   nov.";
RL   Syst. Appl. Microbiol. 37:79-88(2014).
CC   -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC       salvage pathways of dTTP synthesis. {ECO:0000256|HAMAP-Rule:MF_00165}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC         ChEBI:CHEBI:456216; EC=2.7.4.9; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00165, ECO:0000256|SAAS:SAAS01114966};
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00165, ECO:0000256|SAAS:SAAS01070220}.
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DR   EMBL; CP015840; ANG66527.1; -; Genomic_DNA.
DR   RefSeq; WP_021828347.1; NZ_CP015840.1.
DR   STRING; 1143323.M787_0278; -.
DR   EnsemblBacteria; ANG66527; ANG66527; M787_004285.
DR   KEGG; cgz:M787_004285; -.
DR   KO; K00943; -.
DR   OrthoDB; 1585072at2; -.
DR   Proteomes; UP000019147; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039430; Thymidylate_kin-like_dom.
DR   InterPro; IPR018095; Thymidylate_kin_CS.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   Pfam; PF02223; Thymidylate_kin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00041; DTMP_kinase; 1.
DR   PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070209};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00165, ECO:0000256|SAAS:SAAS01070206,
KW   ECO:0000313|EMBL:ANG66527.1};
KW   Nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070211};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070205};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070204}.
FT   DOMAIN          5..193
FT                   /note="Thymidylate_kin"
FT                   /evidence="ECO:0000259|Pfam:PF02223"
FT   NP_BIND         7..14
FT                   /note="ATP"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00165"
SQ   SEQUENCE   208 AA;  23123 MW;  3F1670ABC8E65A67 CRC64;
     MFIVIEGCEG AGKSSLAQLL ANKLITAGKS VVSTREPGGS VLGEKLRQWI LDPQPPNSPH
     AELFLFLASR AQHISEIILP ALDLGKIVIC ERFHDSTIVY QGIAEGLGED YVADLCYRVV
     GNESFLPDLT CLLDIPVTEG IERKQRQKAL DKFENKPLEY HSQVREGFLS LARKNINSYL
     VLDGTMPIEE SLSKVYLRIQ NLSYETSC
//
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