ID A0A173KV67_9SPHN Unreviewed; 883 AA.
AC A0A173KV67;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=EP837_01484 {ECO:0000313|EMBL:ANI77906.1};
OS Sphingobium sp. EP60837.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingobium.
OX NCBI_TaxID=1855519 {ECO:0000313|EMBL:ANI77906.1, ECO:0000313|Proteomes:UP000078304};
RN [1] {ECO:0000313|EMBL:ANI77906.1, ECO:0000313|Proteomes:UP000078304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EP60837 {ECO:0000313|EMBL:ANI77906.1,
RC ECO:0000313|Proteomes:UP000078304};
RA Lee C.-M., Yoon S.-H., Kim B.-Y.;
RT "Complete genome sequence of a organophosphorus pesticides.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP015986; ANI77906.1; -; Genomic_DNA.
DR RefSeq; WP_066525960.1; NZ_CP015986.1.
DR AlphaFoldDB; A0A173KV67; -.
DR STRING; 1855519.EP837_01484; -.
DR KEGG; sphb:EP837_01484; -.
DR PATRIC; fig|1855519.3.peg.1514; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000078304; Chromosome 1.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000078304}.
FT DOMAIN 707..723
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 633..640
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 883 AA; 93774 MW; DDE253ACE943A643 CRC64;
MHSPKDLAAN QPTPMMAQYL ALKAEAQDCL LFYRMGDFFE LFFDDAKAAA ATLDIALTSR
GEHGGAPIPM CGVPVHSAES YLARLIKAGH RVAIAEQTET PAEAKARGSK ALVARAIVRY
VTAGTLTEET LLDSRRDNML VALAQTGGDG AGEIGIAAAD ISTGRFETLT LRPADLPAEL
ARLRPSEVVV PDGLALDLAD SHPFDRAAFS SNRAEAALKR LFGVATLDGF GQFGRAELAA
MGGLIGYLDH AGKGTLPFLA PPVRKTSGAH VAIDAATRES LEITTTMNGA RPGSLLGAVD
RTVTGAGARL LAQDLSAPLM DQGLIEARLG LVQLFHDDPL LRDQLRAALR ALPDIGRALG
RIAVGRGSPR DLGQLRDGLN EARMLRERLG RLPDQPPLLL QLLPALDGHG ALVDSLSRAL
VPSPPTETAN GGYIADGYDP ALDELRRMAG DGRRAIAALE AKYREQSGIG SLKIRHNGVL
GYHVEVPARA ADPLMQPDSG FTHRQTLAGV VRFNSVDLHE QAGRVAQAGA HALAAEAAHL
EDLIESALTR KSEIALAADA LARLDVAAAL AERAAEGGWQ RPHFLPQDGE GPCLEIIGGR
HPVVEDALRR EGQPFVANDC RLGASDRLWL VTGPNMGGKS TFLRQNALIV ILAQAGAYVP
AQSATLTLVD RLFSRVGASD NLARGRSTFM VEMVETAAIL AQATERSFVI LDEVGRGTST
YDGLALAWAV VEAVHEVNRC RCLFATHYHE LTRLAETLSA LSLHHVRARE WKGDLVLLHE
LAQGPADRSY GLAVARLAGL PPAVLKRAKD VLTRLEAGKA KTGGIAAGLD DLPLFAAAAA
HEEDKVDPLR AALDAIDADA LSPREALEQL YHLKQLAAAS SED
//
