UniProt: A0A173WUB2

Database: UniProt
Entry: A0A173WUB2_9FIRM

LinkDB:  A0A173WUB2_9FIRM 
Original site:  A0A173WUB2_9FIRM

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Ontology (4)   
   GO (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (10)   
   EMBL (10)   
Protein domain (11)   
   InterPro (8)   
   Pfam (2)   
   PROSITE (1)   
All databases (27)   

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ID   A0A173WUB2_9FIRM        Unreviewed;       500 AA.
AC   A0A173WUB2;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE            EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN   Name=cysG {ECO:0000313|EMBL:CUN42127.1};
GN   Synonyms=cobA {ECO:0000313|EMBL:RGN07253.1};
GN   ORFNames=DW021_03790 {ECO:0000313|EMBL:RHL49475.1}, DW222_01760
GN   {ECO:0000313|EMBL:RHH21186.1}, DW767_03335
GN   {ECO:0000313|EMBL:RHE14828.1}, DW859_01385
GN   {ECO:0000313|EMBL:RHC10097.1}, DWW07_03795
GN   {ECO:0000313|EMBL:RGV65683.1}, DWX77_00525
GN   {ECO:0000313|EMBL:RGS76225.1}, DWY46_04190
GN   {ECO:0000313|EMBL:RGR50591.1}, DWZ12_06125
GN   {ECO:0000313|EMBL:RGQ06043.1}, DXB81_01610
GN   {ECO:0000313|EMBL:RGN07253.1}, ERS852394_00192
GN   {ECO:0000313|EMBL:CUN42127.1};
OS   Blautia obeum.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Blautia.
OX   NCBI_TaxID=40520 {ECO:0000313|EMBL:CUN42127.1, ECO:0000313|Proteomes:UP000095409};
RN   [1] {ECO:0000313|EMBL:CUN42127.1, ECO:0000313|Proteomes:UP000095409}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2789STDY5608837 {ECO:0000313|EMBL:CUN42127.1,
RC   ECO:0000313|Proteomes:UP000095409};
RG   Pathogen Informatics;
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000261222, ECO:0000313|Proteomes:UP000265808}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF14-23 {ECO:0000313|EMBL:RGV65683.1,
RC   ECO:0000313|Proteomes:UP000265828}, AF21-24
RC   {ECO:0000313|EMBL:RGS76225.1, ECO:0000313|Proteomes:UP000284242},
RC   AF25-21 {ECO:0000313|EMBL:RGR50591.1,
RC   ECO:0000313|Proteomes:UP000285839}, AF29-2BH
RC   {ECO:0000313|EMBL:RGQ06043.1, ECO:0000313|Proteomes:UP000283585},
RC   AF37-6AC {ECO:0000313|EMBL:RHL49475.1,
RC   ECO:0000313|Proteomes:UP000285897}, AM18-2AC
RC   {ECO:0000313|EMBL:RHH21186.1, ECO:0000313|Proteomes:UP000284024},
RC   AM29-25AC {ECO:0000313|EMBL:RHE14828.1,
RC   ECO:0000313|Proteomes:UP000284644}, AM37-4AC
RC   {ECO:0000313|EMBL:RHC10097.1, ECO:0000313|Proteomes:UP000265808}, and
RC   OM06-11AA {ECO:0000313|EMBL:RGN07253.1,
RC   ECO:0000313|Proteomes:UP000261222};
RA   Zou Y., Xue W., Luo G.;
RT   "A genome reference for cultivated species of the human gut microbiota.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC       {ECO:0000256|RuleBase:RU003960}.
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DR   EMBL; CYZD01000001; CUN42127.1; -; Genomic_DNA.
DR   EMBL; QSUB01000001; RGN07253.1; -; Genomic_DNA.
DR   EMBL; QRSS01000005; RGQ06043.1; -; Genomic_DNA.
DR   EMBL; QRUH01000002; RGR50591.1; -; Genomic_DNA.
DR   EMBL; QRVV01000001; RGS76225.1; -; Genomic_DNA.
DR   EMBL; QRZI01000002; RGV65683.1; -; Genomic_DNA.
DR   EMBL; QSHL01000001; RHC10097.1; -; Genomic_DNA.
DR   EMBL; QSJW01000002; RHE14828.1; -; Genomic_DNA.
DR   EMBL; QRJH01000001; RHH21186.1; -; Genomic_DNA.
DR   EMBL; QROS01000002; RHL49475.1; -; Genomic_DNA.
DR   RefSeq; WP_022389402.1; NZ_SPFW01000001.1.
DR   AlphaFoldDB; A0A173WUB2; -.
DR   Proteomes; UP000095409; Unassembled WGS sequence.
DR   Proteomes; UP000261222; Unassembled WGS sequence.
DR   Proteomes; UP000265808; Unassembled WGS sequence.
DR   Proteomes; UP000265828; Unassembled WGS sequence.
DR   Proteomes; UP000283585; Unassembled WGS sequence.
DR   Proteomes; UP000284024; Unassembled WGS sequence.
DR   Proteomes; UP000284242; Unassembled WGS sequence.
DR   Proteomes; UP000284644; Unassembled WGS sequence.
DR   Proteomes; UP000285839; Unassembled WGS sequence.
DR   Proteomes; UP000285897; Unassembled WGS sequence.
DR   GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0019354; P:siroheme biosynthetic process; IEA:InterPro.
DR   CDD; cd06578; HemD; 1.
DR   CDD; cd11642; SUMT; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   InterPro; IPR006366; CobA/CysG_C.
DR   InterPro; IPR003043; Uropor_MeTrfase_CS.
DR   NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR   PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   Pfam; PF00590; TP_methylase; 1.
DR   SUPFAM; SSF69618; HemD-like; 1.
DR   SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR   PROSITE; PS00840; SUMT_2; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000256|RuleBase:RU003960};
KW   Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095409};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003960}.
FT   DOMAIN          5..216
FT                   /note="Tetrapyrrole methylase"
FT                   /evidence="ECO:0000259|Pfam:PF00590"
FT   DOMAIN          267..492
FT                   /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT                   synthase"
FT                   /evidence="ECO:0000259|Pfam:PF02602"
SQ   SEQUENCE   500 AA;  54347 MW;  2EA8E78D4E9EE2A7 CRC64;
     MKKGKVWLVG AGPGDIGLFT LKGMEVLQQA EVVVYDSLVG QGVLAKVPTT ARLIDVGKRA
     DKHTMPQEQI NQVLLEEAQK GQRVVRLKGG DPFLFGRGGE ELELLTVNGI PYEIVPGVTS
     SIAVPAYNGI PVTHRDFCSS VHIITGHRRA GKEYDIDFKA LVNTKGTLVF LMGIAALSDI
     CFGLLEAGMD PAMPAAVLQK GTTADQKRVV ATVATLKEEV DRQGIETPAI IVVGKVCRLA
     DEFGWYEKLP LAGWKVLVTR PKGRSSRTAE ELRRRGAEVL ELPSIRTVPL EDQSTLVHAF
     EEISSYQWIV FTSPTGVEIF FDELKKAHKD IRSLAGAQIA AIGQGTAKVL EDRGILVDLI
     PEVYDGESLG EALAVKLQGG EKILLPRARK GNQKLVKILK EQGGQVSDIP TYDTVYEKSS
     LIHIDREIES DSIDCVVFTS ASTVKGFVES TGLLDYSKVT AACIGKQTKA AADDYGMQTY
     MSEKATIDSL VELVVKIKNR
//

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