ID A0A173XUM8_9FIRM Unreviewed; 440 AA.
AC A0A173XUM8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|ARBA:ARBA00018893, ECO:0000256|HAMAP-Rule:MF_00377};
GN Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN ECO:0000313|EMBL:RGC06143.1};
GN ORFNames=C4N22_07620 {ECO:0000313|EMBL:RAW59578.1}, C4N23_08725
GN {ECO:0000313|EMBL:RAW60470.1}, C4N25_11445
GN {ECO:0000313|EMBL:RAW48378.1}, CGS58_08620
GN {ECO:0000313|EMBL:PDX81314.1}, CHR60_00780
GN {ECO:0000313|EMBL:PDX88107.1}, CRH10_07875
GN {ECO:0000313|EMBL:ATL90222.1}, DW816_09615
GN {ECO:0000313|EMBL:RGC38016.1}, DW905_06870
GN {ECO:0000313|EMBL:RGC06143.1}, DWZ89_10745
GN {ECO:0000313|EMBL:RGB70456.1}, GKD95_09215
GN {ECO:0000313|EMBL:MSC63502.1};
OS Faecalibacterium prausnitzii.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Faecalibacterium.
OX NCBI_TaxID=853 {ECO:0000313|EMBL:RGC06143.1, ECO:0000313|Proteomes:UP000261079};
RN [1] {ECO:0000313|Proteomes:UP000220005, ECO:0000313|Proteomes:UP000220904}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AHMP21 {ECO:0000313|EMBL:PDX88107.1,
RC ECO:0000313|Proteomes:UP000220904}, and CNCM I 4575
RC {ECO:0000313|EMBL:PDX81314.1, ECO:0000313|Proteomes:UP000220005};
RX PubMed=28970823; DOI=10.3389/fmicb.2017.01790;
RA Benevides L., Burman S., Martin R., Robert V., Thomas M., Miquel S.,
RA Chain F., Sokol H., Bermudez-Humaran L.G., Morrison M., Langella P.,
RA Azevedo V.A., Chatel J.M., Soares S.;
RT "New Insights into the Diversity of the Genus Faecalibacterium.";
RL Front. Microbiol. 8:1790-1790(2017).
RN [2] {ECO:0000313|EMBL:PDX81314.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CNCM I 4575 {ECO:0000313|EMBL:PDX81314.1};
RA Sun Z.S., Albrecht U., Echele G., Lee C.C.;
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ATL90222.1, ECO:0000313|Proteomes:UP000223709}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indica {ECO:0000313|EMBL:ATL90222.1,
RC ECO:0000313|Proteomes:UP000223709};
RA Bag S., Ghosh T.S., Das B.;
RT "Complete Genome Sequence of Faecalibacterium prausnitzii isolated from the
RT gut of healthy adult Indian.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Proteomes:UP000250429, ECO:0000313|Proteomes:UP000250583}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=APC922/41-1 {ECO:0000313|EMBL:RAW60470.1,
RC ECO:0000313|Proteomes:UP000250429}, APC923/61-1
RC {ECO:0000313|EMBL:RAW59578.1, ECO:0000313|Proteomes:UP000250583}, and
RC APC942/8-14-2 {ECO:0000313|EMBL:RAW48378.1,
RC ECO:0000313|Proteomes:UP000251634};
RA Fitzgerald B.C., Shkoporov A.N., Ross P.R., Hill C.;
RT "Complete genome sequencing of Faecalibacterium prausnitzii strains
RT isolated from the human gut.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Proteomes:UP000260919, ECO:0000313|Proteomes:UP000261079}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF36-11AT {ECO:0000313|EMBL:RGB70456.1,
RC ECO:0000313|Proteomes:UP000261140}, AM33-14AC
RC {ECO:0000313|EMBL:RGC38016.1, ECO:0000313|Proteomes:UP000260919}, and
RC AM42-11AC {ECO:0000313|EMBL:RGC06143.1,
RC ECO:0000313|Proteomes:UP000261079};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:MSC63502.1, ECO:0000313|Proteomes:UP000461506}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BIOML-A1 {ECO:0000313|EMBL:MSC63502.1,
RC ECO:0000313|Proteomes:UP000461506};
RX PubMed=31477907; DOI=.1038/s41591-019-0559-3;
RA Poyet M., Groussin M., Gibbons S.M., Avila-Pacheco J., Jiang X.,
RA Kearney S.M., Perrotta A.R., Berdy B., Zhao S., Lieberman T.D.,
RA Swanson P.K., Smith M., Roesemann S., Alexander J.E., Rich S.A., Livny J.,
RA Vlamakis H., Clish C., Bullock K., Deik A., Scott J., Pierce K.A.,
RA Xavier R.J., Alm E.J.;
RT "A library of human gut bacterial isolates paired with longitudinal
RT multiomics data enables mechanistic microbiome research.";
RL Nat. Med. 25:1442-1452(2019).
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_00377}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|ARBA:ARBA00006583,
CC ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU004227}.
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DR EMBL; CP023819; ATL90222.1; -; Genomic_DNA.
DR EMBL; WKQN01000008; MSC63502.1; -; Genomic_DNA.
DR EMBL; NMTY01000016; PDX81314.1; -; Genomic_DNA.
DR EMBL; NOUV01000004; PDX88107.1; -; Genomic_DNA.
DR EMBL; PRKZ01000009; RAW48378.1; -; Genomic_DNA.
DR EMBL; PRLE01000003; RAW59578.1; -; Genomic_DNA.
DR EMBL; PRLC01000011; RAW60470.1; -; Genomic_DNA.
DR EMBL; QVEQ01000010; RGB70456.1; -; Genomic_DNA.
DR EMBL; QVEZ01000003; RGC06143.1; -; Genomic_DNA.
DR EMBL; QVFC01000008; RGC38016.1; -; Genomic_DNA.
DR RefSeq; WP_005929139.1; NZ_WQOL01000048.1.
DR KEGG; fpra:CG447_08950; -.
DR OrthoDB; 9807019at2; -.
DR Proteomes; UP000220005; Unassembled WGS sequence.
DR Proteomes; UP000220904; Unassembled WGS sequence.
DR Proteomes; UP000223709; Chromosome.
DR Proteomes; UP000250429; Unassembled WGS sequence.
DR Proteomes; UP000250583; Unassembled WGS sequence.
DR Proteomes; UP000251634; Unassembled WGS sequence.
DR Proteomes; UP000260919; Unassembled WGS sequence.
DR Proteomes; UP000261079; Unassembled WGS sequence.
DR Proteomes; UP000261140; Unassembled WGS sequence.
DR Proteomes; UP000461506; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd00009; AAA; 1.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.300.180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR024633; DnaA_N_dom.
DR InterPro; IPR038454; DnaA_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR NCBIfam; TIGR00362; DnaA; 1.
DR PANTHER; PTHR30050; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR PANTHER; PTHR30050:SF2; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR Pfam; PF11638; DnaA_N; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48295; TrpR-like; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00377};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00377};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW Rule:MF_00377};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00377};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00377}.
FT DOMAIN 136..266
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 348..417
FT /note="Chromosomal replication initiator DnaA C-terminal"
FT /evidence="ECO:0000259|SMART:SM00760"
FT BINDING 144..151
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00377"
SQ SEQUENCE 440 AA; 49484 MW; 6900E529782C098F CRC64;
MDSFKDVLEA AQAYCKTQMA EPTYNLYIDG LEPISFEDSS HITLSVRNDF ICKIVTDRYL
GLLKEAFKTV LGFDVDITLV VPSTPPHEVV LAQQYEANPA SPQGNYEFTF ENFIKGPSNQ
FAFAAAQAVA ANPSGAYNPL FIYGGSGLGK THLLTAIQTE IKRTHPDFVI MYVTCEQFTN
ELIAAIRAGS TEDFRMKYRV ADLLLVDDIQ FIAGKESTQE EFFHTFNSLH DAHKQIVIAS
DRPAKEIKSL EERLRTRFEW GLTADVQPPD FETRVAIVKR KAELLHLDLP EDVAEFIANH
LKNNIRQLEG AVKKLNAYYM LEGIQPVISV AQNAIKDILN ETQPVPVTIE KIVGEVSRTF
NVSPADIRGT KRNANVASAR RVAIYILREV TGMSMEEIGR EFSGRDHSTI VYSLKTMERD
MKNDQHLRET VSDIIKNVKA
//