ID A0A174AC88_9CLOT Unreviewed; 494 AA.
AC A0A174AC88;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN Name=phoR_4 {ECO:0000313|EMBL:CUN85360.1};
GN ORFNames=ERS852471_00577 {ECO:0000313|EMBL:CUN85360.1};
OS Clostridium disporicum.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=84024 {ECO:0000313|EMBL:CUN85360.1, ECO:0000313|Proteomes:UP000095594};
RN [1] {ECO:0000313|EMBL:CUN85360.1, ECO:0000313|Proteomes:UP000095594}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2789STDY5834856 {ECO:0000313|EMBL:CUN85360.1,
RC ECO:0000313|Proteomes:UP000095594};
RG Pathogen Informatics;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CYZX01000003; CUN85360.1; -; Genomic_DNA.
DR RefSeq; WP_055263731.1; NZ_CYZX01000003.1.
DR AlphaFoldDB; A0A174AC88; -.
DR OrthoDB; 9813394at2; -.
DR Proteomes; UP000095594; Unassembled WGS sequence.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR43547:SF2; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C; 1.
DR PANTHER; PTHR43547; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF08448; PAS_4; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:CUN85360.1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000095594};
KW Transferase {ECO:0000313|EMBL:CUN85360.1};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 1..45
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 98..168
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 239..463
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 206..233
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 494 AA; 56849 MW; 85C5E2C8774A2F19 CRC64;
MESVFNCIDE CIMVLDEKNI IKFCNKSLLN ILGYNLNDIQ KKNLINIIQG INNFDSDGEV
IIYNKENTPV QFTYKVNNAI WKGNSAKILV LKEKELYTKA DLEKILENIP LLVWMRDLEG
KYIYVNRAYC DFMKLSKDEI IGKRDRDFLC KEDSSVIEEE DRRLIKEKCN IIEQEELRIK
NKLALFFVAK DVAVDKDGDV KYVFGVAHDI TDIKKIEEKR RELEKEIEVE KIRNEFFNNI
SHEFKTPLNV LLSTTQLIGS HIKERDIKEI SGEKIKNYIE MIENNSYRLL RLTDNLIDMT
KIDTGEYKIN LENKDIVSIV EDVVLTACDC MGNFSGEIIF DTNVEERIVA CDQEKIEKVI
LNLLSNAVKY GNDNGEIFVN INSYEDSVEI SVKDNGIGIS PENINNIFER FGQEDKSLSR
KQEGSGLGLA LVKSVVEMHN GTINVQSELG KGSNFIITLP AKRVVKSEQL KFNICNQTIF
EKCMIEFSDI YAII
//
