ID   A0A174B0J1_9BACE        Unreviewed;      1907 AA.
AC   A0A174B0J1;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Large extracellular alpha-helical protein {ECO:0000313|EMBL:CUN93165.1};
GN   ORFNames=ERS852397_01056 {ECO:0000313|EMBL:CUN93165.1};
OS   Bacteroides finegoldii.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=338188 {ECO:0000313|EMBL:CUN93165.1, ECO:0000313|Proteomes:UP000095517};
RN   [1] {ECO:0000313|EMBL:CUN93165.1, ECO:0000313|Proteomes:UP000095517}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2789STDY5608840 {ECO:0000313|EMBL:CUN93165.1,
RC   ECO:0000313|Proteomes:UP000095517};
RG   Pathogen Informatics;
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000256|ARBA:ARBA00010556}.
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DR   EMBL; CYZH01000005; CUN93165.1; -; Genomic_DNA.
DR   RefSeq; WP_055278624.1; NZ_CYZH01000005.1.
DR   STRING; 338188.ERS852397_01056; -.
DR   Proteomes; UP000095517; Unassembled WGS sequence.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.60.40.1930; -; 1.
DR   InterPro; IPR041246; Bact_MG10.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR11412:SF136; ALPHA-2-MACROGLOBULIN HOMOLOG-RELATED; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF17973; bMG10; 1.
DR   Pfam; PF01835; MG2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000095517};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..1907
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5008018060"
FT   DOMAIN          1143..1233
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
SQ   SEQUENCE   1907 AA;  215456 MW;  8834F325E1ACADB3 CRC64;
     MKVRQICMMV LLGLGVIPAM QAQTFDKLWK EVEQAEKKSL PKTVIKLTDE IYQKGEKERN
     SAQMLKAYMW RMKTQDILTP DSFYVGLRDL EQWAKQTEQP MDRAILHSLI AEFYANYAAD
     NQWQLRQRTE IVGETPSADI REWTANMFVE KVRTNVKEAL ADSLLLLKTS SLNYIPFVEL
     GETSEYYHHD MYHLLASRAI RALNQIERLE RGSFNGITAS PVKQDIVNIY ERMTDAYETA
     GLKEGYVLTM LQYLEWKRGN DNKLQPVQLK KGLGEWTADT YNAALDELKR QFKSEPICAE
     VYLAQVRYAV EKMQQVNALQ LCDEAIRLYP GYRRINALKN LREEILAPFL NVSAVSQAFP
     NEEIKLNVEH KNLDGFTVRL YQAKKLVKEQ HYSVLRPKDY RAKDTVFTFK APDLGTYVMR
     IIPDIRAKRD SESKFNVTRF KVLTCRLPEN QYEVVTLDGQ TGHPIPNAKV TLYSSDEKVL
     QEFTTDKEGK VVFLRNTKYR YLKASKGTDT AMPKQGIYGG SYGYYGNKDK AVEEMTLLTD
     RSLYRPGQTV YVKGIAFAQK SDTADVIPNK AYTVTLYDAN YQEVGRKSVR TNEFGSFATD
     FALPSACLNG VFSLTAGEGG TTVRVEDYKR PTFDITFEKQ TESYKLGDEV QVKGKIQSYS
     GVSLQDLPVK YTVKRSAYNL WRISGAVQIA SGEVTANENG EFTIPVRLEE SDEYKNNDRV
     YYRYSIEATV TNVAGETQSS TDVIPAGNRS LVLQMELDKK TCKDRPFDIV FKAQNLNEQP
     VEVNGNYYLY PLEETNVKES SLKETGFKKA SENPVATGTF TSNKEMTLDW KNLPSGTYML
     KAVAKDSQGK EVETEAQTIL FSIGDKRPPV KSPTWFYAEN TEFDATHPAV FCFGTSEKDT
     YVMMNVFCGD KQLESKALNL SDTIVRFTYP YLESYGDGIF VNFCMVRDGQ LYQEQVSVEK
     RLADKTLTMK WEVFRDNLRP GQKEEWKLTI KTPQGQAADA EMLATMYDAS LDKIWNRRQD
     FRLYYNRILP NFRWMNGYWG NNSFNYWWNN KTLKVPVLAY DYFVMPSRIG NVFFESEILA
     DGVMIRGGGV QKKAAMTGSV ASRSNVVEVK YVPALVSEAT DAEFEEETLP DAPADLRTNL
     AETAFFYPQL RTNEQGEISF SFTMPESLTR WNFRGYSHTK GMLTGTLDGE ATTSKEFMLT
     PNLPRFVRVG DKTSIAASIS NMTGKPQAGT VSMILFDPMT EKVVSTQKQK FSVAAGKTIG
     VNFRFTVNDK YEILGCRMIA DSGTFSDGEQ QLLPVLSNKE HLVETLPMPV RGEETRTFSL
     DSLFNQHSKT ATDRKLTIEF TGNPAWYAIQ ALPSLSLPVN NNAISWATAY YANTLASYIM
     NSQPRIKAVF DSWKLQGGTK ETFLSDLQKN QEVKNILLSE SPWVLEAKTE EQQKERIATL
     FDLNNIRSNN IAALTRLQEL QNSDGAWSWF KGMNGSRYVT AYIAELNARL ALLTGAPLSG
     TALDLQAKAL TYLHQSALEE YKNILKAQKK GVKQTGVSSG ILQYLYIVAI SGEQVPAASK
     IAYAYYLSKV GELLTSSSME TKAIAAIVLD KAGRKKEAQE FVASLKEHLT KTDEQGMFFA
     FNENPYAWGG MKLQAHVDVM EALELIGGNG NRETVEEMKL WLLKQKQTQQ WSSPVATADA
     VYALLMKGAN LLDNQGDVRI VIANEVLETV SPSKTTVPGL GYIKRSFTQK NVVDARKIEV
     EKRNPGIAWG AVYAEYDSPI SDVKQQGGAL NVEKQLYVER IENNVAQLQP ITSKTVLTVG
     DKVVSRLTIS VDRTMDFVQL KDQRGACFEP VGSISGYRWN NGFGYYVDIK DASTNFFFDH
     LGKGVYVLEY GYRVSREGTY ETGLVTIQCA YAPEYVSHSA SMTIIIE
//