ID   A0A174BR87_9CLOT        Unreviewed;       392 AA.
AC   A0A174BR87;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Phosphosugar isomerase {ECO:0000313|EMBL:CUO02200.1};
DE            EC=5.3.1.- {ECO:0000313|EMBL:CUO02200.1};
GN   Name=agaS {ECO:0000313|EMBL:CUO02200.1};
GN   ORFNames=ERS852471_00830 {ECO:0000313|EMBL:CUO02200.1};
OS   Clostridium disporicum.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=84024 {ECO:0000313|EMBL:CUO02200.1, ECO:0000313|Proteomes:UP000095594};
RN   [1] {ECO:0000313|EMBL:CUO02200.1, ECO:0000313|Proteomes:UP000095594}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2789STDY5834856 {ECO:0000313|EMBL:CUO02200.1,
RC   ECO:0000313|Proteomes:UP000095594};
RG   Pathogen Informatics;
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-galactosamine 6-phosphate + H2O = D-tagatopyranose 1-
CC         phosphate + NH4(+); Xref=Rhea:RHEA:47680, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:28938, ChEBI:CHEBI:71674, ChEBI:CHEBI:138150;
CC         Evidence={ECO:0000256|ARBA:ARBA00029292};
CC   -!- SIMILARITY: Belongs to the SIS family. AgaS subfamily.
CC       {ECO:0000256|ARBA:ARBA00007748}.
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DR   EMBL; CYZX01000004; CUO02200.1; -; Genomic_DNA.
DR   RefSeq; WP_055264219.1; NZ_CYZX01000004.1.
DR   AlphaFoldDB; A0A174BR87; -.
DR   OrthoDB; 9779207at2; -.
DR   Proteomes; UP000095594; Unassembled WGS sequence.
DR   GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR   CDD; cd05010; SIS_AgaS_like; 1.
DR   CDD; cd05008; SIS_GlmS_GlmD_1; 1.
DR   InterPro; IPR035466; GlmS/AgaS_SIS.
DR   InterPro; IPR035464; SIS_AgaS.
DR   InterPro; IPR001347; SIS_dom.
DR   InterPro; IPR046348; SIS_dom_sf.
DR   PANTHER; PTHR32502:SF3; D-GALACTOSAMINE-6-PHOSPHATE DEAMINASE AGAS-RELATED; 1.
DR   PANTHER; PTHR32502; N-ACETYLGALACTOSAMINE PERMEASE II COMPONENT-RELATED; 1.
DR   Pfam; PF01380; SIS; 2.
DR   SUPFAM; SSF53697; SIS domain; 1.
DR   PROSITE; PS51464; SIS; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Isomerase {ECO:0000313|EMBL:CUO02200.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095594};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          48..200
FT                   /note="SIS"
FT                   /evidence="ECO:0000259|PROSITE:PS51464"
FT   DOMAIN          219..371
FT                   /note="SIS"
FT                   /evidence="ECO:0000259|PROSITE:PS51464"
SQ   SEQUENCE   392 AA;  43947 MW;  5FFCD74B6B4BB5AF CRC64;
     MNIFNINEEQ MKKTLSSFTL KEIYQQPKTW LKTLNQIKES KQAIQSFIDK VIKCDDFDVI
     LTGAGTSEFI GNSLYSYLNK ELNYKVKSYG TTDIVATPEN YLSKTKPTLL VSFGRSGNSP
     ESIGAVEAAS VVCNNLYNLF ITCNKDGALS KMADELDNCY AINLTDETHD QSFAMTSSFS
     NMYLAAYLCF NLDELEQKES MLNKVCSSTQ NFLDNNYEIA SKIIDEFNFE RIVYLGSNTL
     KGISQESSLK MLELTAGKTV AVFDTPLGFR HGPKSIIDDS TLTVIYVSND EYTYKYELDL
     IREISSQRKN NKLVVVSDKH SEELDTLADY TVSYNINSNA NNAELGLAYI TFAQTLAVLK
     SLSMDLTPDN PCPSGEVNRV VKGVTLYQYT CK
//