ID   A0A174FPA4_9BACE        Unreviewed;       735 AA.
AC   A0A174FPA4;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=Alpha-N-acetylglucosaminidase {ECO:0000313|EMBL:CUO52092.1, ECO:0000313|EMBL:KAA5503819.1};
DE            EC=3.2.1.50 {ECO:0000313|EMBL:CUO52092.1};
GN   ORFNames=ERS852494_00087 {ECO:0000313|EMBL:CUO52092.1}, F2Y31_00775
GN   {ECO:0000313|EMBL:KAA5503819.1};
OS   Bacteroides caccae.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=47678 {ECO:0000313|EMBL:CUO52092.1, ECO:0000313|Proteomes:UP000095657};
RN   [1] {ECO:0000313|EMBL:CUO52092.1, ECO:0000313|Proteomes:UP000095657}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2789STDY5834880 {ECO:0000313|EMBL:CUO52092.1,
RC   ECO:0000313|Proteomes:UP000095657};
RG   Pathogen Informatics;
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KAA5503819.1, ECO:0000313|Proteomes:UP000368418}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BIOML-A19 {ECO:0000313|EMBL:KAA5503819.1,
RC   ECO:0000313|Proteomes:UP000368418};
RX   PubMed=31477907; DOI=.1038/s41591-019-0559-3;
RA   Poyet M., Groussin M., Gibbons S.M., Avila-Pacheco J., Jiang X.,
RA   Kearney S.M., Perrotta A.R., Berdy B., Zhao S., Lieberman T.D.,
RA   Swanson P.K., Smith M., Roesemann S., Alexander J.E., Rich S.A., Livny J.,
RA   Vlamakis H., Clish C., Bullock K., Deik A., Scott J., Pierce K.A.,
RA   Xavier R.J., Alm E.J.;
RT   "A library of human gut bacterial isolates paired with longitudinal
RT   multiomics data enables mechanistic microbiome research.";
RL   Nat. Med. 25:1442-1452(2019).
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DR   EMBL; CZAI01000001; CUO52092.1; -; Genomic_DNA.
DR   EMBL; VVYD01000001; KAA5503819.1; -; Genomic_DNA.
DR   STRING; 47678.ERS852494_00087; -.
DR   Proteomes; UP000095657; Unassembled WGS sequence.
DR   Proteomes; UP000368418; Unassembled WGS sequence.
DR   GO; GO:0004561; F:alpha-N-acetylglucosaminidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProt.
DR   Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 1.20.120.670; N-acetyl-b-d-glucoasminidase; 1.
DR   InterPro; IPR029018; Hex-like_dom2.
DR   InterPro; IPR007781; NAGLU.
DR   InterPro; IPR024732; NAGLU_C.
DR   InterPro; IPR024240; NAGLU_N.
DR   InterPro; IPR024733; NAGLU_tim-barrel.
DR   PANTHER; PTHR12872; ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR   PANTHER; PTHR12872:SF1; ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR   Pfam; PF05089; NAGLU; 1.
DR   Pfam; PF12972; NAGLU_C; 1.
DR   Pfam; PF12971; NAGLU_N; 1.
PE   4: Predicted;
KW   Glycosidase {ECO:0000313|EMBL:CUO52092.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CUO52092.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095657};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..735
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5039781481"
FT   DOMAIN          29..107
FT                   /note="Alpha-N-acetylglucosaminidase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12971"
FT   DOMAIN          121..454
FT                   /note="Alpha-N-acetylglucosaminidase tim-barrel"
FT                   /evidence="ECO:0000259|Pfam:PF05089"
FT   DOMAIN          464..727
FT                   /note="Alpha-N-acetylglucosaminidase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12972"
SQ   SEQUENCE   735 AA;  85521 MW;  E08DEBD3A1C8DE1A CRC64;
     MKYMKKLSLF ILACICTLGS YADDVAVFNA LVNRLLPDYS SQITGKKLPE GKNDYFQLSS
     VGDKIEIAGN NANSMAVGLN YYLKYYCNTN VSWFVDDHLD MPATLPAVDK KVTVDARCKD
     RFFLNYCTFG YTMPWWQWED WEHFIDWMAL NGINLPLAIT GQESIWLKVW TKLGLSESEV
     RNYFTGPAHL PWHRMLNIDY WQGNLPMSWL DGQEELQKKI VARERELNMK PVLPAFAGHV
     PQELKRIYPD AKITKLGAWA GYSDQYACSF LDPMDPLFTK IQKMFLEEQN SIYGTDHIYG
     IDLFNELEAP SYEPSYLRRV SRQVYQSLEK ADKKAVWLQM TWLFWNEKKD WTNERIKAYI
     TAFPSKKSLL LDYYCERHEV WQQTDKYFGV PYIWCYLGNF GGNTVLVGNL YDINKRLENT
     FANGGKNFEG LGSTLEGFDC NPFVYNYVFE KAWDMDIHKD VPRWTEELAV RRIGKDNAKG
     KAAWKLLIDS IYADPSRPGQ CAMLSIRPTF GKFKTYYANP RFRYSNKTLL TILGLMLEAD
     GKGASYSFDV VNVTRQLLGN YFWAVFKDYE KAYQKGDFKT MKAKEQLMLG ILSDMDRVLS
     TQSAFLMGKW ISDARKLGAN EKEKLYFEQN ARNLLTTWGE KASLLNDYAS RSWSGLISTF
     YAERWKMFFA AVDRAVLAGQ NFDDAKYEDY KKDVTEYEER WWKDCIGTFP EQPVGNSVII
     SKELYDKYKP LIEEM
//