ID A0A174G9D9_9CLOT Unreviewed; 295 AA.
AC A0A174G9D9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Tyrosine recombinase XerC {ECO:0000256|HAMAP-Rule:MF_01808};
GN Name=xerD_4 {ECO:0000313|EMBL:CUO58531.1};
GN Synonyms=xerC {ECO:0000256|HAMAP-Rule:MF_01808}, xerD
GN {ECO:0000313|EMBL:RGD68079.1};
GN ORFNames=DWX31_24115 {ECO:0000313|EMBL:RGD68079.1}, DXC39_15770
GN {ECO:0000313|EMBL:RGM03193.1}, DXD79_15325
GN {ECO:0000313|EMBL:RGJ03747.1}, ERS852407_03282
GN {ECO:0000313|EMBL:CUO58531.1};
OS Hungatella hathewayi.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae; Hungatella.
OX NCBI_TaxID=154046 {ECO:0000313|EMBL:CUO58531.1, ECO:0000313|Proteomes:UP000095651};
RN [1] {ECO:0000313|EMBL:CUO58531.1, ECO:0000313|Proteomes:UP000095651}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2789STDY5608850 {ECO:0000313|EMBL:CUO58531.1,
RC ECO:0000313|Proteomes:UP000095651};
RG Pathogen Informatics;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000261023, ECO:0000313|Proteomes:UP000261257}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF19-13AC {ECO:0000313|EMBL:RGD68079.1,
RC ECO:0000313|Proteomes:UP000261023}, TF05-11AC
RC {ECO:0000313|EMBL:RGM03193.1, ECO:0000313|Proteomes:UP000261257}, and
RC TM09-12 {ECO:0000313|EMBL:RGJ03747.1,
RC ECO:0000313|Proteomes:UP000263014};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC the cutting and rejoining of the recombining DNA molecules. The XerC-
CC XerD complex is essential to convert dimers of the bacterial chromosome
CC into monomers to permit their segregation at cell division. It also
CC contributes to the segregational stability of plasmids.
CC {ECO:0000256|HAMAP-Rule:MF_01808}.
CC -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two
CC molecules of XerC and two molecules of XerD. {ECO:0000256|HAMAP-
CC Rule:MF_01808}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_01808}.
CC -!- SIMILARITY: Belongs to the 'phage' integrase family. XerC subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01808}.
CC -!- SIMILARITY: Belongs to the 'phage' integrase family. XerD subfamily.
CC {ECO:0000256|ARBA:ARBA00010450}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_01808}.
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DR EMBL; CYZE01000008; CUO58531.1; -; Genomic_DNA.
DR EMBL; QTJW01000019; RGD68079.1; -; Genomic_DNA.
DR EMBL; QSON01000006; RGJ03747.1; -; Genomic_DNA.
DR EMBL; QSSQ01000015; RGM03193.1; -; Genomic_DNA.
DR RefSeq; WP_002602131.1; NZ_QTJW01000019.1.
DR AlphaFoldDB; A0A174G9D9; -.
DR OrthoDB; 9801717at2; -.
DR Proteomes; UP000095651; Unassembled WGS sequence.
DR Proteomes; UP000261023; Unassembled WGS sequence.
DR Proteomes; UP000261257; Unassembled WGS sequence.
DR Proteomes; UP000263014; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006313; P:DNA transposition; IEA:UniProtKB-UniRule.
DR CDD; cd00798; INT_XerDC_C; 1.
DR Gene3D; 1.10.150.130; -; 1.
DR Gene3D; 1.10.443.10; Intergrase catalytic core; 1.
DR HAMAP; MF_01808; Recomb_XerC_XerD; 1.
DR InterPro; IPR044068; CB.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR002104; Integrase_catalytic.
DR InterPro; IPR010998; Integrase_recombinase_N.
DR InterPro; IPR004107; Integrase_SAM-like_N.
DR InterPro; IPR011932; Recomb_XerD.
DR InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD.
DR NCBIfam; TIGR02225; recomb_XerD; 1.
DR PANTHER; PTHR30349; PHAGE INTEGRASE-RELATED; 1.
DR PANTHER; PTHR30349:SF87; PROPHAGE INTEGRASE INTD-RELATED; 1.
DR Pfam; PF02899; Phage_int_SAM_1; 1.
DR Pfam; PF00589; Phage_integrase; 1.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR PROSITE; PS51900; CB; 1.
DR PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP-
KW Rule:MF_01808};
KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP-
KW Rule:MF_01808};
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829, ECO:0000256|HAMAP-
KW Rule:MF_01808};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01808};
KW DNA integration {ECO:0000256|ARBA:ARBA00022908, ECO:0000256|HAMAP-
KW Rule:MF_01808};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172, ECO:0000256|HAMAP-
KW Rule:MF_01808};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_01808}; Reference proteome {ECO:0000313|Proteomes:UP000095651}.
FT DOMAIN 1..85
FT /note="Core-binding (CB)"
FT /evidence="ECO:0000259|PROSITE:PS51900"
FT DOMAIN 106..289
FT /note="Tyr recombinase"
FT /evidence="ECO:0000259|PROSITE:PS51898"
FT ACT_SITE 146
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808"
FT ACT_SITE 240
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808"
FT ACT_SITE 243
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808"
FT ACT_SITE 266
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808"
FT ACT_SITE 275
FT /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808"
SQ SEQUENCE 295 AA; 33417 MW; AA3ACEE4E9C10285 CRC64;
MVTEINEFVK YLREVKKTSK NTEVSYQRDL LQLASYLEAQ GITDVEKVTK TSLNSYVLYL
EKEGRATTTI SRTLASMKAF FHYEFGEGRI RRDPAELIKA PKIEKKAPTI LTVEEVNSLL
EQPNGDSPKE IRDKAMLELL YATGIRVSEL INLKVEDINL AVGFITCRDE HKERMIPFGK
VAKQAMLNYM ENGRVSLLKG QESEWLFTNC SGRPMSRQGF WKIIKFYGEK AGIQADITPH
TLRHSFAAHL LKNGADIHAV QAMMGHSDMA TTQMYMNYAQ GEAVRSAYAG AHPRN
//
