ID A0A174GWA6_9BACE Unreviewed; 690 AA.
AC A0A174GWA6;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=HDIG domain-containing protein {ECO:0000313|EMBL:KAA5229014.1};
DE SubName: Full=Membrane-associated HD superfamily hydrolase {ECO:0000313|EMBL:CUO65388.1};
GN ORFNames=ERS852397_02486 {ECO:0000313|EMBL:CUO65388.1}, F2Z22_15750
GN {ECO:0000313|EMBL:KAA5229014.1};
OS Bacteroides finegoldii.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=338188 {ECO:0000313|EMBL:CUO65388.1, ECO:0000313|Proteomes:UP000095517};
RN [1] {ECO:0000313|EMBL:CUO65388.1, ECO:0000313|Proteomes:UP000095517}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2789STDY5608840 {ECO:0000313|EMBL:CUO65388.1,
RC ECO:0000313|Proteomes:UP000095517};
RG Pathogen Informatics;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAA5229014.1, ECO:0000313|Proteomes:UP000421791}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BIOML-A6 {ECO:0000313|EMBL:KAA5229014.1,
RC ECO:0000313|Proteomes:UP000421791};
RX PubMed=31477907; DOI=.1038/s41591-019-0559-3;
RA Poyet M., Groussin M., Gibbons S.M., Avila-Pacheco J., Jiang X.,
RA Kearney S.M., Perrotta A.R., Berdy B., Zhao S., Lieberman T.D.,
RA Swanson P.K., Smith M., Roesemann S., Alexander J.E., Rich S.A., Livny J.,
RA Vlamakis H., Clish C., Bullock K., Deik A., Scott J., Pierce K.A.,
RA Xavier R.J., Alm E.J.;
RT "A library of human gut bacterial isolates paired with longitudinal
RT multiomics data enables mechanistic microbiome research.";
RL Nat. Med. 25:1442-1452(2019).
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DR EMBL; CYZH01000013; CUO65388.1; -; Genomic_DNA.
DR EMBL; VWAK01000030; KAA5229014.1; -; Genomic_DNA.
DR RefSeq; WP_007755684.1; NZ_VWAO01000030.1.
DR AlphaFoldDB; A0A174GWA6; -.
DR STRING; 338188.ERS852397_02486; -.
DR GeneID; 61623376; -.
DR Proteomes; UP000095517; Unassembled WGS sequence.
DR Proteomes; UP000421791; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR006675; HDIG_dom.
DR InterPro; IPR011624; Metal-dep_PHydrolase_7TM_extra.
DR InterPro; IPR011621; Metal-dep_PHydrolase_7TM_intra.
DR NCBIfam; TIGR00277; HDIG; 1.
DR PANTHER; PTHR36442; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR PANTHER; PTHR36442:SF1; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR Pfam; PF07698; 7TM-7TMR_HD; 1.
DR Pfam; PF07697; 7TMR-HDED; 1.
DR Pfam; PF01966; HD; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:CUO65388.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000095517};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 15..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 481..625
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
SQ SEQUENCE 690 AA; 79437 MW; 09581FACE8F4EBC8 CRC64;
MEHLKKKKSF SWKDLSYKSL LFIGTVALIV YFLPRDGKFN YQFDINKPWK YGQLIATFDF
PIYKDEAIVK REQDSLMALF QPYYELDKKV EKEAIAKLKE NYHTNLKGIL PSTDYLRYIE
RTLKEIYQAG IVSTEAIQQL YKDSTSAIMV IDDKLANSHP IEGIYTVKKA YEYLLTADSV
HFNREILRQC SLNEYISPNL TFDEQRTQTA KEEILNNYSW ANGLVVSGQK IIDRGEIISP
ETYNILESLR KESIKRNESM GQSRLILGGQ ILFVGMLMLC FMLYLDLFRK DYYQRKGSLS
LLFTLIVFYS IVTAFMMTHN LFNVYIIPYA MLPIIIRVFL DSRTAFLTHV ITILICSISL
RFPHEFILTQ LAAGMVAIFS LRELSQRSQL FRTALLVILT YAAVYFSFEL MTENGLANDF
SKLNIRMYTY FFINGILLLF AYPLLFLLEK TFGFTSNVTL VELSNINNDL LRQMSETVPG
TFQHSMQVAN LAAEAAIRIG AKSQLVRTGA LYHDIGKMEN PAFFTENQSG GVNPHKNLGY
EQSAQVVISH VTDGLKLADK HNLPKVIKDF ISTHHGRGKT KYFYISWKNE HPDEELNEEL
FTYPGPNPFT KEQAILMMAD AVEAASRSLP EYTEETISNL VDKIIDSQVT EGYFKECPIT
FKDIATVKAV FKEKLKIAYH TRISYPELKK
//