UniProt: A0A174KLZ9

Database: UniProt
Entry: A0A174KLZ9_9CLOT

LinkDB:  A0A174KLZ9_9CLOT 
Original site:  A0A174KLZ9_9CLOT

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Ontology (4)   
   GO (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (8)   
   InterPro (5)   
   Pfam (2)   
   PROSITE (1)   
All databases (15)   

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ID   A0A174KLZ9_9CLOT        Unreviewed;      1174 AA.
AC   A0A174KLZ9;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   Name=addB {ECO:0000313|EMBL:CUP13184.1};
GN   ORFNames=ERS852407_05075 {ECO:0000313|EMBL:CUP13184.1};
OS   Hungatella hathewayi.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae; Hungatella.
OX   NCBI_TaxID=154046 {ECO:0000313|EMBL:CUP13184.1, ECO:0000313|Proteomes:UP000095651};
RN   [1] {ECO:0000313|EMBL:CUP13184.1, ECO:0000313|Proteomes:UP000095651}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2789STDY5608850 {ECO:0000313|EMBL:CUP13184.1,
RC   ECO:0000313|Proteomes:UP000095651};
RG   Pathogen Informatics;
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; CYZE01000018; CUP13184.1; -; Genomic_DNA.
DR   RefSeq; WP_055659401.1; NZ_CYZE01000018.1.
DR   AlphaFoldDB; A0A174KLZ9; -.
DR   Proteomes; UP000095651; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR049035; ADDB_N.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   PANTHER; PTHR30591; RECBCD ENZYME SUBUNIT RECC; 1.
DR   PANTHER; PTHR30591:SF1; RECBCD ENZYME SUBUNIT RECC; 1.
DR   Pfam; PF21445; ADDB_N; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CUP13184.1};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095651}.
FT   DOMAIN          317..604
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   REGION          288..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1174 AA;  133638 MW;  BD938D6AF3B6F6B5 CRC64;
     MSIQLLTGGS GSGKTHRLYT DLIRDSIENP DTKYFAIVPE QFTMQTQKEI VTLHPNHGVM
     NIDIVSFQRL AYRVFEELAI INPDVLDDMG KSMILRKVTG GKQKELPLYQ SHLNQNGFIG
     QLKSMLSELY QYGITPEMLD AKIPETTSPM LRQKLEDISV IYKAFKEYIK DRYITTEEIL
     DVLCKHLPES RLIKDSVITL DGYTGFTPVQ YRLLDLFLRY SRRVIVTVTI DPSVAERGKG
     GVQDLFHMSS EMMDKLNALA RQNHVKREPD IVLDDHPAVR YRSGVKQRVE MPEEQQMEPP
     AEQPGKQPVA PDALAADTPS HSALDFLEQN LYRYSGRVYS GKAEEIRLVQ AVNPAGEISH
     VVRQIGKLLR EGYRYRDMAV ITGDIGSFAG ELIHQFDASE IPYFLDDKKS ILKNPMVELV
     RAALETIQKD FSYETVFRYL RTGLVTKPED ERRLDRLENY VIAMGIRGLK RWNTTWEGWY
     RGGKDLNLEE LNQLREEIMA PLTAFIEAFR EEGRTVRTMT EAVVRLLEAL SVEEKMLARE
     ASFREQGEFG LAKEYGQVYG LVVDLMDRLA RLLGDEKVSR REYAEILDAG FSEIKVGLIP
     AAVDRIVVGD ITRTRLDHIK ILFFIGVNDG IVPQKKENSS LFTDKEREFL GSHHIELAPT
     VRVESFRQRF YLYLALTKPA ERLYLSFSAM DASGKSLRPS ILLGELRKLF PQLTVVAASD
     EAAGVPLSIR EARGRLTHGL RNFEMTREDS EFLELFRHFM MDEEQRENVK RLVDAAFYAY
     EERGIGKMAA KALYGTVLGG SVTRLEQYAS CAYAHFLNYG LELAERQQYE LAAMDIGNLF
     HDSIDLCFKK MKEQGGDWKT IGEDERKALV HTAVTEVTEE YGNTILKSSA RNAYLARKVE
     KITDRTIWAL AEQLKKGDFM PVGFEVSFSA ADNLKAMKIA LSEEEALHLR GRIDRMDLCE
     DEEHVYVKII DYKSGGTSFD LTALYYGLQL QLVVYMDAAM EMEERRNPDK AVIPAGIFYY
     NINDPVIDRE GDMTPEAIDR RILKELRMNG LVNSELEVIS HLDHEIETES DVIPVAMKNG
     LIQEAKSSVA GGNRFSALKR YVNEKLKTEG REILEGAVAV NPYKQGNKTA CDYCPYHAVC
     GFDLKTSGFG FRKFKPLKSE EIWPEIEGEQ QDGD
//

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