ID A0A174MCN7_9BACT Unreviewed; 155 AA.
AC A0A174MCN7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Transcription elongation factor GreA {ECO:0000256|HAMAP-Rule:MF_00105, ECO:0000256|RuleBase:RU000556};
DE AltName: Full=Transcript cleavage factor GreA {ECO:0000256|HAMAP-Rule:MF_00105};
GN Name=greA {ECO:0000256|HAMAP-Rule:MF_00105,
GN ECO:0000313|EMBL:MQO71654.1};
GN ORFNames=DW026_12295 {ECO:0000313|EMBL:RHL34915.1}, DW192_11675
GN {ECO:0000313|EMBL:RHH79379.1}, DWV76_02160
GN {ECO:0000313|EMBL:RGW44555.1}, DWX90_07715
GN {ECO:0000313|EMBL:RGS47137.1}, DWZ10_08255
GN {ECO:0000313|EMBL:RGQ09189.1}, DXB80_07325
GN {ECO:0000313|EMBL:RGN09745.1}, F7D28_11175
GN {ECO:0000313|EMBL:MQO96175.1}, F7D42_00925
GN {ECO:0000313|EMBL:MQO54297.1}, F7D58_04355
GN {ECO:0000313|EMBL:MQO71654.1}, F7D66_08950
GN {ECO:0000313|EMBL:MQO01346.1}, F7D71_13630
GN {ECO:0000313|EMBL:MQN78879.1}, F7D72_11385
GN {ECO:0000313|EMBL:MQN69643.1}, F7E03_11075
GN {ECO:0000313|EMBL:MQM50580.1}, FYJ72_06110
GN {ECO:0000313|EMBL:MST77260.1};
OS Segatella copri.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Segatella.
OX NCBI_TaxID=165179 {ECO:0000313|EMBL:MQO71654.1, ECO:0000313|Proteomes:UP000486770};
RN [1] {ECO:0000313|Proteomes:UP000261245, ECO:0000313|Proteomes:UP000283459}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF12-50 {ECO:0000313|EMBL:RGW44555.1,
RC ECO:0000313|Proteomes:UP000283785}, AF22-1
RC {ECO:0000313|EMBL:RGS47137.1, ECO:0000313|Proteomes:UP000286113},
RC AF29-19 {ECO:0000313|EMBL:RGQ09189.1,
RC ECO:0000313|Proteomes:UP000283459}, AF38-11
RC {ECO:0000313|EMBL:RHL34915.1, ECO:0000313|Proteomes:UP000283672},
RC AM16-54 {ECO:0000313|EMBL:RHH79379.1,
RC ECO:0000313|Proteomes:UP000284548}, and OM06-11
RC {ECO:0000313|EMBL:RGN09745.1, ECO:0000313|Proteomes:UP000261245};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:MST77260.1, ECO:0000313|Proteomes:UP000450161}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LKV-178-WT-2C {ECO:0000313|EMBL:MST77260.1,
RC ECO:0000313|Proteomes:UP000450161};
RA Wylensek D., Hitch T.C.A., Clavel T.;
RT "In-depth cultivation of the pig gut microbiome towards novel bacterial
RT diversity and tailored functional studies.";
RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000358159, ECO:0000313|Proteomes:UP000384796}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BU4165 {ECO:0000313|EMBL:MQO01346.1,
RC ECO:0000313|Proteomes:UP000473126}, BU41712
RC {ECO:0000313|EMBL:MQN78879.1, ECO:0000313|Proteomes:UP000423156},
RC BU41813 {ECO:0000313|EMBL:MQN69643.1,
RC ECO:0000313|Proteomes:UP000384796}, BVe4116
RC {ECO:0000313|EMBL:MQO96175.1, ECO:0000313|Proteomes:UP000427436},
RC BVe41219 {ECO:0000313|EMBL:MQO54297.1,
RC ECO:0000313|Proteomes:UP000358159}, iAK2716
RC {ECO:0000313|Proteomes:UP000486770}, IT212
RC {ECO:0000313|EMBL:MQM50580.1}, and iT212
RC {ECO:0000313|Proteomes:UP000440283};
RA Fehlner-Peach H., Magnabosco C., Raghavan V., Scher J.U., Tett A.,
RA Cox L.M., Gottsegen C., Watters A., Wiltshire- Gordon J.D., Segata N.,
RA Bonneau R., Littman D.R.;
RT "Distinct polysaccharide growth profiles of human intestinal Prevotella
RT copri isolates.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:MQO71654.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IAK2716 {ECO:0000313|EMBL:MQO71654.1};
RA Fehlner-Peach H., Magnabosco C., Raghavan V., Scher J.U., Tett A.,
RA Cox L.M., Gottsegen C., Watters A., Wiltshire- Gordon J.D., Segata N.,
RA Bonneau R., Littman D.R.;
RT "Distinct polysaccharide growth profiles of human intestinal Prevotella
RT copri isolates.";
RL Submitted (SEP-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Necessary for efficient RNA polymerase transcription
CC elongation past template-encoded arresting sites. The arresting sites
CC in DNA have the property of trapping a certain fraction of elongating
CC RNA polymerases that pass through, resulting in locked ternary
CC complexes. Cleavage of the nascent transcript by cleavage factors such
CC as GreA or GreB allows the resumption of elongation from the new
CC 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
CC {ECO:0000256|ARBA:ARBA00024916, ECO:0000256|HAMAP-Rule:MF_00105,
CC ECO:0000256|RuleBase:RU000556}.
CC -!- SIMILARITY: Belongs to the GreA/GreB family. {ECO:0000256|HAMAP-
CC Rule:MF_00105, ECO:0000256|RuleBase:RU000556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MQO71654.1}.
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DR EMBL; VZDE01000069; MQM50580.1; -; Genomic_DNA.
DR EMBL; VZCA01000078; MQN69643.1; -; Genomic_DNA.
DR EMBL; VZBZ01000154; MQN78879.1; -; Genomic_DNA.
DR EMBL; VZBX01000085; MQO01346.1; -; Genomic_DNA.
DR EMBL; VZAZ01000001; MQO54297.1; -; Genomic_DNA.
DR EMBL; VZAT01000036; MQO71654.1; -; Genomic_DNA.
DR EMBL; VZAK01000060; MQO96175.1; -; Genomic_DNA.
DR EMBL; VUNF01000008; MST77260.1; -; Genomic_DNA.
DR EMBL; QSUC01000015; RGN09745.1; -; Genomic_DNA.
DR EMBL; QRSU01000019; RGQ09189.1; -; Genomic_DNA.
DR EMBL; QRVN01000013; RGS47137.1; -; Genomic_DNA.
DR EMBL; QSAG01000002; RGW44555.1; -; Genomic_DNA.
DR EMBL; QRKB01000032; RHH79379.1; -; Genomic_DNA.
DR EMBL; QROP01000039; RHL34915.1; -; Genomic_DNA.
DR RefSeq; WP_006847697.1; NZ_WQNW01000001.1.
DR GeneID; 69847782; -.
DR eggNOG; COG0782; Bacteria.
DR Proteomes; UP000261245; Unassembled WGS sequence.
DR Proteomes; UP000283459; Unassembled WGS sequence.
DR Proteomes; UP000283672; Unassembled WGS sequence.
DR Proteomes; UP000283785; Unassembled WGS sequence.
DR Proteomes; UP000284548; Unassembled WGS sequence.
DR Proteomes; UP000286113; Unassembled WGS sequence.
DR Proteomes; UP000358159; Unassembled WGS sequence.
DR Proteomes; UP000384796; Unassembled WGS sequence.
DR Proteomes; UP000423156; Unassembled WGS sequence.
DR Proteomes; UP000427436; Unassembled WGS sequence.
DR Proteomes; UP000440283; Unassembled WGS sequence.
DR Proteomes; UP000450161; Unassembled WGS sequence.
DR Proteomes; UP000473126; Unassembled WGS sequence.
DR Proteomes; UP000486770; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0070063; F:RNA polymerase binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.10.50.30; Transcription elongation factor, GreA/GreB, C-terminal domain; 1.
DR Gene3D; 1.10.287.180; Transcription elongation factor, GreA/GreB, N-terminal domain; 1.
DR HAMAP; MF_00105; GreA_GreB; 1.
DR InterPro; IPR036953; GreA/GreB_C_sf.
DR InterPro; IPR006359; Tscrpt_elong_fac_GreA.
DR InterPro; IPR028624; Tscrpt_elong_fac_GreA/B.
DR InterPro; IPR001437; Tscrpt_elong_fac_GreA/B_C.
DR InterPro; IPR023459; Tscrpt_elong_fac_GreA/B_fam.
DR InterPro; IPR022691; Tscrpt_elong_fac_GreA/B_N.
DR InterPro; IPR036805; Tscrpt_elong_fac_GreA/B_N_sf.
DR NCBIfam; TIGR01462; greA; 1.
DR PANTHER; PTHR30437; TRANSCRIPTION ELONGATION FACTOR GREA; 1.
DR PANTHER; PTHR30437:SF4; TRANSCRIPTION ELONGATION FACTOR GREA; 1.
DR Pfam; PF01272; GreA_GreB; 1.
DR Pfam; PF03449; GreA_GreB_N; 1.
DR PIRSF; PIRSF006092; GreA_GreB; 1.
DR SUPFAM; SSF54534; FKBP-like; 1.
DR SUPFAM; SSF46557; GreA transcript cleavage protein, N-terminal domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00105}; Elongation factor {ECO:0000313|EMBL:MQO71654.1};
KW Protein biosynthesis {ECO:0000313|EMBL:MQO71654.1};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00105};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00105}.
FT DOMAIN 3..72
FT /note="Transcription elongation factor GreA/GreB N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF03449"
FT DOMAIN 79..153
FT /note="Transcription elongation factor GreA/GreB C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01272"
SQ SEQUENCE 155 AA; 17128 MW; B67867B1F0776870 CRC64;
MAYMSQEGYD KLVAELKQLV SVERPKASAA IAEARDKGDL SENSEYDAAK EAQAHLEDKI
NRLKLTIAEA KIIDTKQLST DSVQIMSKVE MTNMANKAKM TYTIVSESEA NLKEGKISIK
TPIAQGLLNK KVGEVAEIKI PRGTINLRID KISFE
//
