ID A0A174MQV4_9CLOT Unreviewed; 401 AA.
AC A0A174MQV4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=ROK family transcriptional regulator {ECO:0000313|EMBL:RGL97063.1};
DE SubName: Full=Transcriptional regulator/sugar kinase {ECO:0000313|EMBL:CUP36580.1};
GN Name=mlc_5 {ECO:0000313|EMBL:CUP36580.1};
GN ORFNames=DXC39_25835 {ECO:0000313|EMBL:RGL97063.1}, ERS852407_05722
GN {ECO:0000313|EMBL:CUP36580.1};
OS Hungatella hathewayi.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae; Hungatella.
OX NCBI_TaxID=154046 {ECO:0000313|EMBL:CUP36580.1, ECO:0000313|Proteomes:UP000095651};
RN [1] {ECO:0000313|EMBL:CUP36580.1, ECO:0000313|Proteomes:UP000095651}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2789STDY5608850 {ECO:0000313|EMBL:CUP36580.1,
RC ECO:0000313|Proteomes:UP000095651};
RG Pathogen Informatics;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:RGL97063.1, ECO:0000313|Proteomes:UP000261257}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TF05-11AC {ECO:0000313|EMBL:RGL97063.1,
RC ECO:0000313|Proteomes:UP000261257};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional repressor of xylose-utilizing enzymes.
CC {ECO:0000256|ARBA:ARBA00002486}.
CC -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family.
CC {ECO:0000256|ARBA:ARBA00006479}.
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DR EMBL; CYZE01000027; CUP36580.1; -; Genomic_DNA.
DR EMBL; QSSQ01000038; RGL97063.1; -; Genomic_DNA.
DR RefSeq; WP_055660358.1; NZ_QSVU01000037.1.
DR AlphaFoldDB; A0A174MQV4; -.
DR Proteomes; UP000095651; Unassembled WGS sequence.
DR Proteomes; UP000261257; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.420.40; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000600; ROK.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR18964:SF177; N-ACETYLMANNOSAMINE KINASE; 1.
DR PANTHER; PTHR18964; ROK (REPRESSOR, ORF, KINASE) FAMILY; 1.
DR Pfam; PF13412; HTH_24; 1.
DR Pfam; PF00480; ROK; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:CUP36580.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000095651};
KW Transferase {ECO:0000313|EMBL:CUP36580.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 373..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 401 AA; 44083 MW; 0D9E75E86AD16FAF CRC64;
MYKGKKKKAS NRSRILECIY RNAPIARTDI AEETEITPAT VTMNVTTLIS EGFVRELGEA
STDEGSSGRK RVLIDIIPDR AYSIGLEFTQ KALVICITDL KGRIRFQHAE PFNEELAGRI
TDAIIDGVKG LVAESGISWD EIVGIGAAVP GHMNGSASSL VTNRKTWQNF DPKRIEQELP
LPIVCENNAR CMALGEYLFS PQESPDSFAF FHVGMGMFCA NVVDGEMFLG ENYVAGEIGH
TIVSEGGRRC ECGKYGCLQT YASENHLIRN AKLLYKNTPN TILRSLVPDD SLITIETITT
AYSMGDPVIG MYIAEALKYL GITISNIAII TNPGKIFLHG QLFDNQDIQN ELMDYIERQL
IFVDRTYAGN VEILPYAAAD GAVGASALAI LRFFIRPAMG E
//
