ID A0A174NI18_9BACE Unreviewed; 370 AA.
AC A0A174NI18;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Peptide chain release factor 1 {ECO:0000256|HAMAP-Rule:MF_00093};
DE Short=RF-1 {ECO:0000256|HAMAP-Rule:MF_00093};
GN Name=prfA {ECO:0000256|HAMAP-Rule:MF_00093,
GN ECO:0000313|EMBL:CUP48213.1};
GN ORFNames=DW190_01295 {ECO:0000313|EMBL:RHH94925.1}, DW794_08215
GN {ECO:0000313|EMBL:RHD49429.1}, DWY26_08910
GN {ECO:0000313|EMBL:RGR72327.1}, DXA49_03170
GN {ECO:0000313|EMBL:RGY28711.1}, ERS852494_02338
GN {ECO:0000313|EMBL:CUP48213.1}, ERS852558_01544
GN {ECO:0000313|EMBL:CUQ00619.1}, F2Y31_07940
GN {ECO:0000313|EMBL:KAA5500360.1}, F2Y36_06900
GN {ECO:0000313|EMBL:KAA5464366.1}, F2Y39_15335
GN {ECO:0000313|EMBL:KAA5474702.1}, NXW23_07500
GN {ECO:0000313|EMBL:UVQ98158.1};
OS Bacteroides caccae.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=47678 {ECO:0000313|EMBL:CUP48213.1, ECO:0000313|Proteomes:UP000095657};
RN [1] {ECO:0000313|Proteomes:UP000095657, ECO:0000313|Proteomes:UP000095725}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2789STDY5834880 {ECO:0000313|EMBL:CUP48213.1,
RC ECO:0000313|Proteomes:UP000095657}, and 2789STDY5834946
RC {ECO:0000313|EMBL:CUQ00619.1, ECO:0000313|Proteomes:UP000095725};
RG Pathogen Informatics;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000283512, ECO:0000313|Proteomes:UP000284205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF24-29LB {ECO:0000313|EMBL:RGR72327.1,
RC ECO:0000313|Proteomes:UP000284205}, AM16-49B
RC {ECO:0000313|EMBL:RHH94925.1, ECO:0000313|Proteomes:UP000283512},
RC AM31-16AC {ECO:0000313|EMBL:RHD49429.1,
RC ECO:0000313|Proteomes:UP000284689}, and OF02-6LB
RC {ECO:0000313|EMBL:RGY28711.1, ECO:0000313|Proteomes:UP000284431};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000368418, ECO:0000313|Proteomes:UP000427825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BIOML-A19 {ECO:0000313|EMBL:KAA5500360.1,
RC ECO:0000313|Proteomes:UP000368418}, BIOML-A25
RC {ECO:0000313|EMBL:KAA5474702.1, ECO:0000313|Proteomes:UP000427825},
RC and BIOML-A31 {ECO:0000313|EMBL:KAA5464366.1,
RC ECO:0000313|Proteomes:UP000475905};
RX PubMed=31477907; DOI=.1038/s41591-019-0559-3;
RA Poyet M., Groussin M., Gibbons S.M., Avila-Pacheco J., Jiang X.,
RA Kearney S.M., Perrotta A.R., Berdy B., Zhao S., Lieberman T.D.,
RA Swanson P.K., Smith M., Roesemann S., Alexander J.E., Rich S.A., Livny J.,
RA Vlamakis H., Clish C., Bullock K., Deik A., Scott J., Pierce K.A.,
RA Xavier R.J., Alm E.J.;
RT "A library of human gut bacterial isolates paired with longitudinal
RT multiomics data enables mechanistic microbiome research.";
RL Nat. Med. 25:1442-1452(2019).
RN [4] {ECO:0000313|EMBL:UVQ98158.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BFG-474 {ECO:0000313|EMBL:UVQ98158.1};
RA Tisza M.J., Smith D., Dekker J.P.;
RT "Genome Sequencing of Bacteroides fragilis Group Isolates with Nanopore
RT Technology.";
RL Submitted (AUG-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Peptide chain release factor 1 directs the termination of
CC translation in response to the peptide chain termination codons UAG and
CC UAA. {ECO:0000256|ARBA:ARBA00002986, ECO:0000256|HAMAP-Rule:MF_00093}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00093}.
CC -!- PTM: Methylated by PrmC. Methylation increases the termination
CC efficiency of RF1. {ECO:0000256|HAMAP-Rule:MF_00093}.
CC -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC family. {ECO:0000256|ARBA:ARBA00010835, ECO:0000256|HAMAP-
CC Rule:MF_00093}.
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DR EMBL; CZAI01000005; CUP48213.1; -; Genomic_DNA.
DR EMBL; CZBL01000005; CUQ00619.1; -; Genomic_DNA.
DR EMBL; VVYP01000006; KAA5464366.1; -; Genomic_DNA.
DR EMBL; VVYJ01000009; KAA5474702.1; -; Genomic_DNA.
DR EMBL; VVYD01000005; KAA5500360.1; -; Genomic_DNA.
DR EMBL; QRUO01000006; RGR72327.1; -; Genomic_DNA.
DR EMBL; QSCS01000004; RGY28711.1; -; Genomic_DNA.
DR EMBL; QSJD01000010; RHD49429.1; -; Genomic_DNA.
DR EMBL; QRKD01000001; RHH94925.1; -; Genomic_DNA.
DR EMBL; CP103166; UVQ98158.1; -; Genomic_DNA.
DR RefSeq; WP_005677299.1; NZ_WQQZ01000001.1.
DR STRING; 47678.ERS852494_02338; -.
DR GeneID; 75112951; -.
DR KEGG; bcac:CGC64_07345; -.
DR Proteomes; UP000095657; Unassembled WGS sequence.
DR Proteomes; UP000095725; Unassembled WGS sequence.
DR Proteomes; UP000283512; Unassembled WGS sequence.
DR Proteomes; UP000284205; Unassembled WGS sequence.
DR Proteomes; UP000284431; Unassembled WGS sequence.
DR Proteomes; UP000284689; Unassembled WGS sequence.
DR Proteomes; UP000368418; Unassembled WGS sequence.
DR Proteomes; UP000427825; Unassembled WGS sequence.
DR Proteomes; UP000475905; Unassembled WGS sequence.
DR Proteomes; UP001060260; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.30.70.1660; -; 2.
DR Gene3D; 6.10.140.1950; -; 1.
DR HAMAP; MF_00093; Rel_fac_1; 1.
DR InterPro; IPR005139; PCRF.
DR InterPro; IPR000352; Pep_chain_release_fac_I.
DR InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR InterPro; IPR004373; RF-1.
DR NCBIfam; TIGR00019; prfA; 1.
DR PANTHER; PTHR43804; LD18447P; 1.
DR PANTHER; PTHR43804:SF7; LD18447P; 1.
DR Pfam; PF03462; PCRF; 1.
DR Pfam; PF00472; RF-1; 1.
DR SMART; SM00937; PCRF; 1.
DR SUPFAM; SSF75620; Release factor; 1.
DR PROSITE; PS00745; RF_PROK_I; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00093};
KW Methylation {ECO:0000256|ARBA:ARBA00022481, ECO:0000256|HAMAP-
KW Rule:MF_00093}; Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_00093};
KW Reference proteome {ECO:0000313|Proteomes:UP000095657}.
FT DOMAIN 232..248
FT /note="Prokaryotic-type class I peptide chain release
FT factors"
FT /evidence="ECO:0000259|PROSITE:PS00745"
FT COILED 47..100
FT /evidence="ECO:0000256|SAM:Coils"
FT MOD_RES 239
FT /note="N5-methylglutamine"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00093"
SQ SEQUENCE 370 AA; 41712 MW; A5A190DBD3BB825B CRC64;
MADNSTILEK LDGLVARFEE ISTLITDPAV IADQKRYVKL TKEYKELDDL MKARKEYMQL
LGNIEEARNI LANESDADMR EMAKEEMDSS QERLPVLEEE IKLMLVPADP QDSKNAILEI
RGGTGGDEAA IFAGDLFRMY AKYCETKGWK MEVSSANEGA AGGFKEIICS VTGDNVYGTL
KYESGVHRVQ RVPATETQGR VHTSAASVAV LPEAEEFDVV INEGEIKWDT FRSGGAGGQN
VNKVESGVRL RYIWKNPNTG VAEEILIECT ETRDQPKNKE RALARLRTFI YDKEHQKYID
DIASKRKTMV STGDRSAKIR TYNYPQGRIT DHRINYTIYN LTAFMDGDIQ DCIDHLIVAE
NAERLKESEL
//
