ID A0A174R399_9FIRM Unreviewed; 341 AA.
AC A0A174R399;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase {ECO:0000256|ARBA:ARBA00020367, ECO:0000256|HAMAP-Rule:MF_00741};
DE EC=6.3.3.1 {ECO:0000256|ARBA:ARBA00013047, ECO:0000256|HAMAP-Rule:MF_00741};
DE AltName: Full=AIR synthase {ECO:0000256|ARBA:ARBA00032931, ECO:0000256|HAMAP-Rule:MF_00741};
DE AltName: Full=AIRS {ECO:0000256|ARBA:ARBA00033093, ECO:0000256|HAMAP-Rule:MF_00741};
DE AltName: Full=Phosphoribosyl-aminoimidazole synthetase {ECO:0000256|ARBA:ARBA00031908, ECO:0000256|HAMAP-Rule:MF_00741};
GN Name=purM {ECO:0000256|HAMAP-Rule:MF_00741,
GN ECO:0000313|EMBL:CUP78651.1};
GN ORFNames=DW021_12525 {ECO:0000313|EMBL:RHL45296.1}, DW040_09025
GN {ECO:0000313|EMBL:RHK95929.1}, DW272_08620
GN {ECO:0000313|EMBL:RHG18057.1}, DW723_07220
GN {ECO:0000313|EMBL:RHE75754.1}, DW767_14980
GN {ECO:0000313|EMBL:RHE10526.1}, DW859_05395
GN {ECO:0000313|EMBL:RHC08332.1}, DWW07_08020
GN {ECO:0000313|EMBL:RGV64754.1}, DWX77_02995
GN {ECO:0000313|EMBL:RGS75547.1}, DWY46_16955
GN {ECO:0000313|EMBL:RGR45392.1}, DWZ12_01750
GN {ECO:0000313|EMBL:RGQ07178.1}, DXB38_11435
GN {ECO:0000313|EMBL:RGN86898.1}, DXB81_15680
GN {ECO:0000313|EMBL:RGN02258.1}, EAI82_06690
GN {ECO:0000313|EMBL:RYT67114.1}, ERS852394_01480
GN {ECO:0000313|EMBL:CUO11009.1}, ERS852533_02542
GN {ECO:0000313|EMBL:CUP78651.1};
OS Blautia obeum.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Blautia.
OX NCBI_TaxID=40520 {ECO:0000313|EMBL:CUP78651.1, ECO:0000313|Proteomes:UP000095413};
RN [1] {ECO:0000313|Proteomes:UP000095409, ECO:0000313|Proteomes:UP000095413}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2789STDY5608837 {ECO:0000313|EMBL:CUO11009.1,
RC ECO:0000313|Proteomes:UP000095409}, and 2789STDY5834921
RC {ECO:0000313|EMBL:CUP78651.1, ECO:0000313|Proteomes:UP000095413};
RG Pathogen Informatics;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000261105, ECO:0000313|Proteomes:UP000261222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF14-23 {ECO:0000313|EMBL:RGV64754.1,
RC ECO:0000313|Proteomes:UP000265828}, AF21-24
RC {ECO:0000313|EMBL:RGS75547.1, ECO:0000313|Proteomes:UP000284242},
RC AF25-21 {ECO:0000313|EMBL:RGR45392.1,
RC ECO:0000313|Proteomes:UP000285839}, AF29-2BH
RC {ECO:0000313|EMBL:RGQ07178.1, ECO:0000313|Proteomes:UP000283585},
RC AF37-6AC {ECO:0000313|EMBL:RHL45296.1,
RC ECO:0000313|Proteomes:UP000285897}, AF39-4
RC {ECO:0000313|EMBL:RHK95929.1, ECO:0000313|Proteomes:UP000284267},
RC AM22-9LB {ECO:0000313|EMBL:RHG18057.1,
RC ECO:0000313|Proteomes:UP000284220}, AM27-32LB
RC {ECO:0000313|EMBL:RHE75754.1, ECO:0000313|Proteomes:UP000283928},
RC AM29-25AC {ECO:0000313|EMBL:RHE10526.1,
RC ECO:0000313|Proteomes:UP000284644}, AM37-4AC
RC {ECO:0000313|EMBL:RHC08332.1, ECO:0000313|Proteomes:UP000265808},
RC OM03-6 {ECO:0000313|EMBL:RGN86898.1,
RC ECO:0000313|Proteomes:UP000261105}, and OM06-11AA
RC {ECO:0000313|EMBL:RGN02258.1, ECO:0000313|Proteomes:UP000261222};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:RYT67114.1, ECO:0000313|Proteomes:UP000293506}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Af_0058 {ECO:0000313|EMBL:RYT67114.1}, and af_0058
RC {ECO:0000313|Proteomes:UP000293506};
RX PubMed=30630933; DOI=.1126/science.aau5238;
RA Jiang X., Hall A.B., Arthur T.D., Plichta D.R., Covington C.T., Poyet M.,
RA Crothers J., Moses P.L., Tolonen A.C., Vlamakis H., Alm E.J., Xavier R.J.;
RT "Invertible promoters mediate bacterial phase variation, antibiotic
RT resistance, and host adaptation in the gut.";
RL Science 363:181-187(2019).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP
CC = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) +
CC phosphate; Xref=Rhea:RHEA:23032, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:137981,
CC ChEBI:CHEBI:147287, ChEBI:CHEBI:456216; EC=6.3.3.1;
CC Evidence={ECO:0000256|ARBA:ARBA00023392, ECO:0000256|HAMAP-
CC Rule:MF_00741};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC phospho-D-ribosyl)glycinamide: step 2/2.
CC {ECO:0000256|ARBA:ARBA00004686, ECO:0000256|HAMAP-Rule:MF_00741}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00741}.
CC -!- SIMILARITY: Belongs to the AIR synthase family.
CC {ECO:0000256|ARBA:ARBA00010280, ECO:0000256|HAMAP-Rule:MF_00741}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CYZD01000006; CUO11009.1; -; Genomic_DNA.
DR EMBL; CZBA01000016; CUP78651.1; -; Genomic_DNA.
DR EMBL; QSUB01000009; RGN02258.1; -; Genomic_DNA.
DR EMBL; QSUZ01000016; RGN86898.1; -; Genomic_DNA.
DR EMBL; QRSS01000002; RGQ07178.1; -; Genomic_DNA.
DR EMBL; QRUH01000019; RGR45392.1; -; Genomic_DNA.
DR EMBL; QRVV01000005; RGS75547.1; -; Genomic_DNA.
DR EMBL; QRZI01000004; RGV64754.1; -; Genomic_DNA.
DR EMBL; QSHL01000003; RHC08332.1; -; Genomic_DNA.
DR EMBL; QSJW01000010; RHE10526.1; -; Genomic_DNA.
DR EMBL; QSKO01000008; RHE75754.1; -; Genomic_DNA.
DR EMBL; QRHZ01000003; RHG18057.1; -; Genomic_DNA.
DR EMBL; QROE01000003; RHK95929.1; -; Genomic_DNA.
DR EMBL; QROS01000010; RHL45296.1; -; Genomic_DNA.
DR EMBL; RCXQ01000005; RYT67114.1; -; Genomic_DNA.
DR RefSeq; WP_005425217.1; NZ_WWVS01000005.1.
DR AlphaFoldDB; A0A174R399; -.
DR GeneID; 79803646; -.
DR OrthoDB; 9802507at2; -.
DR UniPathway; UPA00074; UER00129.
DR Proteomes; UP000095409; Unassembled WGS sequence.
DR Proteomes; UP000095413; Unassembled WGS sequence.
DR Proteomes; UP000261105; Unassembled WGS sequence.
DR Proteomes; UP000261222; Unassembled WGS sequence.
DR Proteomes; UP000265808; Unassembled WGS sequence.
DR Proteomes; UP000265828; Unassembled WGS sequence.
DR Proteomes; UP000283585; Unassembled WGS sequence.
DR Proteomes; UP000283928; Unassembled WGS sequence.
DR Proteomes; UP000284220; Unassembled WGS sequence.
DR Proteomes; UP000284242; Unassembled WGS sequence.
DR Proteomes; UP000284267; Unassembled WGS sequence.
DR Proteomes; UP000284644; Unassembled WGS sequence.
DR Proteomes; UP000285839; Unassembled WGS sequence.
DR Proteomes; UP000285897; Unassembled WGS sequence.
DR Proteomes; UP000293506; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004641; F:phosphoribosylformylglycinamidine cyclo-ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd02196; PurM; 1.
DR Gene3D; 3.90.650.10; PurM-like C-terminal domain; 1.
DR Gene3D; 3.30.1330.10; PurM-like, N-terminal domain; 1.
DR HAMAP; MF_00741; AIRS; 1.
DR InterPro; IPR010918; PurM-like_C_dom.
DR InterPro; IPR036676; PurM-like_C_sf.
DR InterPro; IPR016188; PurM-like_N.
DR InterPro; IPR036921; PurM-like_N_sf.
DR InterPro; IPR004733; PurM_cligase.
DR NCBIfam; TIGR00878; purM; 1.
DR PANTHER; PTHR10520:SF12; TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3; 1.
DR PANTHER; PTHR10520; TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED; 1.
DR Pfam; PF00586; AIRS; 1.
DR Pfam; PF02769; AIRS_C; 1.
DR SUPFAM; SSF56042; PurM C-terminal domain-like; 1.
DR SUPFAM; SSF55326; PurM N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00741}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00741};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|HAMAP-Rule:MF_00741};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00741}; Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00741};
KW Reference proteome {ECO:0000313|Proteomes:UP000095409}.
FT DOMAIN 53..160
FT /note="PurM-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00586"
FT DOMAIN 172..337
FT /note="PurM-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02769"
SQ SEQUENCE 341 AA; 36450 MW; F1DE295F82864936 CRC64;
MDYKKAGVDI EAGYKSVELM KKHIAKTMRP EVLGGIGGFS GAFSMNAFKN MEEPTLVSGT
DGCGTKVKLA MIMDKHDTIG IDAVAMCVND IACAGAEPLF FLDYIACGKN YPEKIAEIVS
GVAEGCVQSG AALIGGETAE HPGLMPEDEY DLAGFAVGVI DKKDLLTGEE LKPGDVLIGM
ASTGVHSNGF SLVRKVFEMT KESLDTYYDE LGTTLGEALL APTRIYVKAL KSVKEAGVRI
HACSHITGGG FYENVPRMLK DGTRAVIEKN SYPVLPIFDL LAKTGDIEEK MMYNTFNMGL
GMVLAVDPSD VDKTMEAIRQ AGDTPYVVGR IEAGEKGVTL C
//
