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Database: UniProt
Entry: A0A174RVF6_9BACE
LinkDB: A0A174RVF6_9BACE
Original site: A0A174RVF6_9BACE 
ID   A0A174RVF6_9BACE        Unreviewed;       145 AA.
AC   A0A174RVF6;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=tRNA-specific adenosine deaminase {ECO:0000256|HAMAP-Rule:MF_00972};
DE            EC=3.5.4.33 {ECO:0000256|HAMAP-Rule:MF_00972};
GN   Name=tadA_2 {ECO:0000313|EMBL:CUP87348.1};
GN   Synonyms=tadA {ECO:0000256|HAMAP-Rule:MF_00972}, tadA_1
GN   {ECO:0000313|EMBL:CUQ41995.1};
GN   ORFNames=DW190_19580 {ECO:0000313|EMBL:RHH85763.1}, DW794_20195
GN   {ECO:0000313|EMBL:RHD42580.1}, DWY26_16885
GN   {ECO:0000313|EMBL:RGR68153.1}, DXA49_06310
GN   {ECO:0000313|EMBL:RGY27653.1}, ERS852494_03291
GN   {ECO:0000313|EMBL:CUP87348.1}, ERS852558_03193
GN   {ECO:0000313|EMBL:CUQ41995.1}, F2Y31_14320
GN   {ECO:0000313|EMBL:KAA5497320.1}, F2Y35_21815
GN   {ECO:0000313|EMBL:KAA5485902.1}, F2Y36_09145
GN   {ECO:0000313|EMBL:KAA5463755.1}, F2Y39_16890
GN   {ECO:0000313|EMBL:KAA5474262.1};
OS   Bacteroides caccae.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=47678 {ECO:0000313|EMBL:CUP87348.1, ECO:0000313|Proteomes:UP000095657};
RN   [1] {ECO:0000313|Proteomes:UP000095657, ECO:0000313|Proteomes:UP000095725}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2789STDY5834880 {ECO:0000313|EMBL:CUP87348.1,
RC   ECO:0000313|Proteomes:UP000095657}, and 2789STDY5834946
RC   {ECO:0000313|EMBL:CUQ41995.1, ECO:0000313|Proteomes:UP000095725};
RG   Pathogen Informatics;
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000283512, ECO:0000313|Proteomes:UP000284205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF24-29LB {ECO:0000313|EMBL:RGR68153.1,
RC   ECO:0000313|Proteomes:UP000284205}, AM16-49B
RC   {ECO:0000313|EMBL:RHH85763.1, ECO:0000313|Proteomes:UP000283512},
RC   AM31-16AC {ECO:0000313|EMBL:RHD42580.1,
RC   ECO:0000313|Proteomes:UP000284689}, and OF02-6LB
RC   {ECO:0000313|EMBL:RGY27653.1, ECO:0000313|Proteomes:UP000284431};
RA   Zou Y., Xue W., Luo G.;
RT   "A genome reference for cultivated species of the human gut microbiota.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000368418, ECO:0000313|Proteomes:UP000427825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BIOML-A19 {ECO:0000313|EMBL:KAA5497320.1,
RC   ECO:0000313|Proteomes:UP000368418}, BIOML-A21
RC   {ECO:0000313|EMBL:KAA5485902.1, ECO:0000313|Proteomes:UP000491168},
RC   BIOML-A25 {ECO:0000313|EMBL:KAA5474262.1,
RC   ECO:0000313|Proteomes:UP000427825}, and BIOML-A31
RC   {ECO:0000313|EMBL:KAA5463755.1, ECO:0000313|Proteomes:UP000475905};
RX   PubMed=31477907; DOI=.1038/s41591-019-0559-3;
RA   Poyet M., Groussin M., Gibbons S.M., Avila-Pacheco J., Jiang X.,
RA   Kearney S.M., Perrotta A.R., Berdy B., Zhao S., Lieberman T.D.,
RA   Swanson P.K., Smith M., Roesemann S., Alexander J.E., Rich S.A., Livny J.,
RA   Vlamakis H., Clish C., Bullock K., Deik A., Scott J., Pierce K.A.,
RA   Xavier R.J., Alm E.J.;
RT   "A library of human gut bacterial isolates paired with longitudinal
RT   multiomics data enables mechanistic microbiome research.";
RL   Nat. Med. 25:1442-1452(2019).
CC   -!- FUNCTION: Catalyzes the deamination of adenosine to inosine at the
CC       wobble position 34 of tRNA(Arg2). {ECO:0000256|HAMAP-Rule:MF_00972}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA +
CC         NH4(+); Xref=Rhea:RHEA:43168, Rhea:RHEA-COMP:10373, Rhea:RHEA-
CC         COMP:10374, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:74411, ChEBI:CHEBI:82852; EC=3.5.4.33;
CC         Evidence={ECO:0000256|ARBA:ARBA00001103, ECO:0000256|HAMAP-
CC         Rule:MF_00972};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00972};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|HAMAP-Rule:MF_00972};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738, ECO:0000256|HAMAP-
CC       Rule:MF_00972}.
CC   -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase
CC       family. ADAT2 subfamily. {ECO:0000256|ARBA:ARBA00010669}.
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DR   EMBL; CZAI01000008; CUP87348.1; -; Genomic_DNA.
DR   EMBL; CZBL01000014; CUQ41995.1; -; Genomic_DNA.
DR   EMBL; VVYP01000009; KAA5463755.1; -; Genomic_DNA.
DR   EMBL; VVYJ01000010; KAA5474262.1; -; Genomic_DNA.
DR   EMBL; VVYF01000034; KAA5485902.1; -; Genomic_DNA.
DR   EMBL; VVYD01000013; KAA5497320.1; -; Genomic_DNA.
DR   EMBL; QRUO01000018; RGR68153.1; -; Genomic_DNA.
DR   EMBL; QSCS01000007; RGY27653.1; -; Genomic_DNA.
DR   EMBL; QSJD01000049; RHD42580.1; -; Genomic_DNA.
DR   EMBL; QRKD01000034; RHH85763.1; -; Genomic_DNA.
DR   RefSeq; WP_005678668.1; NZ_WQQZ01000027.1.
DR   STRING; 47678.ERS852494_03291; -.
DR   GeneID; 75111270; -.
DR   KEGG; bcac:CGC64_00310; -.
DR   Proteomes; UP000095657; Unassembled WGS sequence.
DR   Proteomes; UP000095725; Unassembled WGS sequence.
DR   Proteomes; UP000283512; Unassembled WGS sequence.
DR   Proteomes; UP000284205; Unassembled WGS sequence.
DR   Proteomes; UP000284431; Unassembled WGS sequence.
DR   Proteomes; UP000284689; Unassembled WGS sequence.
DR   Proteomes; UP000368418; Unassembled WGS sequence.
DR   Proteomes; UP000427825; Unassembled WGS sequence.
DR   Proteomes; UP000475905; Unassembled WGS sequence.
DR   Proteomes; UP000491168; Unassembled WGS sequence.
DR   GO; GO:0052717; F:tRNA-specific adenosine-34 deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0002100; P:tRNA wobble adenosine to inosine editing; IEA:UniProtKB-UniRule.
DR   CDD; cd01285; nucleoside_deaminase; 1.
DR   Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR   HAMAP; MF_00972; tRNA_aden_deaminase; 1.
DR   InterPro; IPR016192; APOBEC/CMP_deaminase_Zn-bd.
DR   InterPro; IPR002125; CMP_dCMP_dom.
DR   InterPro; IPR016193; Cytidine_deaminase-like.
DR   InterPro; IPR028883; tRNA_aden_deaminase.
DR   PANTHER; PTHR11079; CYTOSINE DEAMINASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR11079:SF179; TRNA(ADENINE(34)) DEAMINASE, CHLOROPLASTIC; 1.
DR   Pfam; PF14437; MafB19-deam; 1.
DR   SUPFAM; SSF53927; Cytidine deaminase-like; 1.
DR   PROSITE; PS00903; CYT_DCMP_DEAMINASES_1; 1.
DR   PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00972, ECO:0000313|EMBL:CUP87348.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW   Rule:MF_00972}; Reference proteome {ECO:0000313|Proteomes:UP000095657};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694, ECO:0000256|HAMAP-
KW   Rule:MF_00972};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|HAMAP-Rule:MF_00972}.
FT   DOMAIN          2..112
FT                   /note="CMP/dCMP-type deaminase"
FT                   /evidence="ECO:0000259|PROSITE:PS51747"
FT   ACT_SITE        55
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00972"
FT   BINDING         53
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00972"
FT   BINDING         83
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00972"
FT   BINDING         86
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00972"
SQ   SEQUENCE   145 AA;  15680 MW;  8369FFBB38DA7BDA CRC64;
     MLDDTYFMKQ ALIEAGKAAE RGEVPVGAVV VCKERIIARA HNLTETLNDV TAHAEMQAIT
     AAANVLGGKY LSECTLYVTV EPCVMCAGAI AWAQTGKLVF GAEDEKRGYQ RYAADALHPK
     TVVVKGILAD ECAALMREFF AAKRK
//
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