ID A0A174U1Z8_9BACE Unreviewed; 948 AA.
AC A0A174U1Z8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Insulinase family protein {ECO:0000313|EMBL:KAA5461040.1};
DE SubName: Full=Putative peptidase {ECO:0000313|EMBL:CUQ15346.1};
GN Name=yhjJ {ECO:0000313|EMBL:CUQ15346.1};
GN ORFNames=DW190_19045 {ECO:0000313|EMBL:RHH85940.1}, DXA49_12215
GN {ECO:0000313|EMBL:RGY24970.1}, ERS852494_04121
GN {ECO:0000313|EMBL:CUQ15346.1}, F2Y35_20055
GN {ECO:0000313|EMBL:KAA5487060.1}, F2Y36_16640
GN {ECO:0000313|EMBL:KAA5461040.1};
OS Bacteroides caccae.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=47678 {ECO:0000313|EMBL:CUQ15346.1, ECO:0000313|Proteomes:UP000095657};
RN [1] {ECO:0000313|EMBL:CUQ15346.1, ECO:0000313|Proteomes:UP000095657}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2789STDY5834880 {ECO:0000313|EMBL:CUQ15346.1,
RC ECO:0000313|Proteomes:UP000095657};
RG Pathogen Informatics;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000283512, ECO:0000313|Proteomes:UP000284431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AM16-49B {ECO:0000313|EMBL:RHH85940.1,
RC ECO:0000313|Proteomes:UP000283512}, and OF02-6LB
RC {ECO:0000313|EMBL:RGY24970.1, ECO:0000313|Proteomes:UP000284431};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000475905, ECO:0000313|Proteomes:UP000491168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BIOML-A21 {ECO:0000313|EMBL:KAA5487060.1,
RC ECO:0000313|Proteomes:UP000491168}, and BIOML-A31
RC {ECO:0000313|EMBL:KAA5461040.1, ECO:0000313|Proteomes:UP000475905};
RX PubMed=31477907; DOI=.1038/s41591-019-0559-3;
RA Poyet M., Groussin M., Gibbons S.M., Avila-Pacheco J., Jiang X.,
RA Kearney S.M., Perrotta A.R., Berdy B., Zhao S., Lieberman T.D.,
RA Swanson P.K., Smith M., Roesemann S., Alexander J.E., Rich S.A., Livny J.,
RA Vlamakis H., Clish C., Bullock K., Deik A., Scott J., Pierce K.A.,
RA Xavier R.J., Alm E.J.;
RT "A library of human gut bacterial isolates paired with longitudinal
RT multiomics data enables mechanistic microbiome research.";
RL Nat. Med. 25:1442-1452(2019).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR EMBL; CZAI01000013; CUQ15346.1; -; Genomic_DNA.
DR EMBL; VVYP01000023; KAA5461040.1; -; Genomic_DNA.
DR EMBL; VVYF01000024; KAA5487060.1; -; Genomic_DNA.
DR EMBL; QSCS01000018; RGY24970.1; -; Genomic_DNA.
DR EMBL; QRKD01000031; RHH85940.1; -; Genomic_DNA.
DR RefSeq; WP_005675534.1; NZ_WQQZ01000032.1.
DR AlphaFoldDB; A0A174U1Z8; -.
DR STRING; 47678.ERS852494_04121; -.
DR KEGG; bcac:CGC64_01310; -.
DR Proteomes; UP000095657; Unassembled WGS sequence.
DR Proteomes; UP000283512; Unassembled WGS sequence.
DR Proteomes; UP000284431; Unassembled WGS sequence.
DR Proteomes; UP000475905; Unassembled WGS sequence.
DR Proteomes; UP000491168; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000095657};
KW Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..948
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038213551"
FT DOMAIN 56..181
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 211..384
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 697..874
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 948 AA; 109104 MW; 20904A2D338DDA4F CRC64;
MFKQTKFKVF LFLAVLLGGL PVNMLAQQKA SHLEKKVNLP PNTVEGTLAN GLHYLILPNE
APIHTTEFRL VMRIGSVQES EEQKGAAHFL EHMSFAGSKH FPGRGMVDYL ETLGMKFGRD
INAVTGYDRT IFMLTVPMDK TDHKVSSKTL LILKDWLSGI TFEEERTKKE RGVILEELRG
YDLGDDFYAL KIGKNHFTER MPLGSSEDIR SIDRKTLIEF YKKWYSPQMA TVVVVGNVDP
ESIEKQIKEM FSSIPRKEVK GYRTYPLTYD PGVELYEIGD DLERSSELEL MIPHPCVIGN
TIGSIYQKEL GSLLIRAISN RLKYQNIRCN VSDAWFLSDK NHFVFAFSGV DKANLLQQVS
ELSNEMESIQ KNGFKQEEVE DAINEHLRRL KVDNSTQLSS KWCDDFVDYV ISDDRYIQSD
SEMKQLADKI RATDSATLQQ LLREWLSYKD QTLLVAYRNN AGKQNSLKKE EVVQAWDEGI
KNPLKDFTYV RKDVKEERVV TPACLVESYP FKASDIVSEK KYADLNITEV ILKNDLRILL
RPTNDESQSI FVTAFGRGGT ADLSDKDYPL YEGTGGYMEM GGVACIPYDT LSSFMQQEEI
SMNIAISNYW HDIMGMSPAA KARELFNLMY EKMCRPELCY EDFDEIRKDE MERFGKESVL
EQMMKRASDR MLTNRLDSLM GNTVPRPALT KMDLERLDLD KIADYYCSLY SNPSQMTFVV
TGKFDTDSIK ELLTATFGRM PKVNTVSYPN KAFKLPKKTY IEEFPNDNDT QTIFDYVFCG
NYQPSLKNSL TLKLMRDILQ NRLLSVLREG ENIVYSPYAS LFYNGLPQQV FYFDLSASVD
FVNTKKVEEL IKQIINELRT SKVSEEELET LKKSFWVTKR KVLSDEASAE WRTNLVNLLK
NGESVADFER YEQCLNSIST VDIQKAFKHF TNPDKFVLLY IGKHQKYE
//
