ID A0A174U540_9BACE Unreviewed; 356 AA.
AC A0A174U540;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Catabolite transcriptional regulator A {ECO:0000313|EMBL:CUQ14770.1};
DE SubName: Full=LacI family DNA-binding transcriptional regulator {ECO:0000313|EMBL:RGY27148.1};
DE SubName: Full=Substrate-binding domain-containing protein {ECO:0000313|EMBL:KAA5478712.1};
GN Name=ccpA_1 {ECO:0000313|EMBL:CUQ14770.1};
GN ORFNames=DW190_10030 {ECO:0000313|EMBL:RHH90759.1}, DXA49_06555
GN {ECO:0000313|EMBL:RGY27148.1}, ERS852494_04063
GN {ECO:0000313|EMBL:CUQ13378.1}, ERS852558_01969
GN {ECO:0000313|EMBL:CUQ14770.1}, F2Y31_12385
GN {ECO:0000313|EMBL:KAA5497957.1}, F2Y35_07610
GN {ECO:0000313|EMBL:KAA5492755.1}, F2Y39_06965
GN {ECO:0000313|EMBL:KAA5478712.1}, NXW23_17485
GN {ECO:0000313|EMBL:UVQ96099.1};
OS Bacteroides caccae.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=47678 {ECO:0000313|EMBL:CUQ14770.1, ECO:0000313|Proteomes:UP000095725};
RN [1] {ECO:0000313|Proteomes:UP000095657, ECO:0000313|Proteomes:UP000095725}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2789STDY5834880 {ECO:0000313|EMBL:CUQ13378.1,
RC ECO:0000313|Proteomes:UP000095657}, and 2789STDY5834946
RC {ECO:0000313|EMBL:CUQ14770.1, ECO:0000313|Proteomes:UP000095725};
RG Pathogen Informatics;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000283512, ECO:0000313|Proteomes:UP000284431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AM16-49B {ECO:0000313|EMBL:RHH90759.1,
RC ECO:0000313|Proteomes:UP000283512}, and OF02-6LB
RC {ECO:0000313|EMBL:RGY27148.1, ECO:0000313|Proteomes:UP000284431};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000368418, ECO:0000313|Proteomes:UP000427825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BIOML-A19 {ECO:0000313|EMBL:KAA5497957.1,
RC ECO:0000313|Proteomes:UP000368418}, BIOML-A21
RC {ECO:0000313|EMBL:KAA5492755.1, ECO:0000313|Proteomes:UP000491168},
RC and BIOML-A25 {ECO:0000313|EMBL:KAA5478712.1,
RC ECO:0000313|Proteomes:UP000427825};
RX PubMed=31477907; DOI=.1038/s41591-019-0559-3;
RA Poyet M., Groussin M., Gibbons S.M., Avila-Pacheco J., Jiang X.,
RA Kearney S.M., Perrotta A.R., Berdy B., Zhao S., Lieberman T.D.,
RA Swanson P.K., Smith M., Roesemann S., Alexander J.E., Rich S.A., Livny J.,
RA Vlamakis H., Clish C., Bullock K., Deik A., Scott J., Pierce K.A.,
RA Xavier R.J., Alm E.J.;
RT "A library of human gut bacterial isolates paired with longitudinal
RT multiomics data enables mechanistic microbiome research.";
RL Nat. Med. 25:1442-1452(2019).
RN [4] {ECO:0000313|EMBL:UVQ96099.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BFG-474 {ECO:0000313|EMBL:UVQ96099.1};
RA Tisza M.J., Smith D., Dekker J.P.;
RT "Genome Sequencing of Bacteroides fragilis Group Isolates with Nanopore
RT Technology.";
RL Submitted (AUG-2022) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CZAI01000012; CUQ13378.1; -; Genomic_DNA.
DR EMBL; CZBL01000007; CUQ14770.1; -; Genomic_DNA.
DR EMBL; VVYJ01000003; KAA5478712.1; -; Genomic_DNA.
DR EMBL; VVYF01000007; KAA5492755.1; -; Genomic_DNA.
DR EMBL; VVYD01000010; KAA5497957.1; -; Genomic_DNA.
DR EMBL; QSCS01000008; RGY27148.1; -; Genomic_DNA.
DR EMBL; QRKD01000007; RHH90759.1; -; Genomic_DNA.
DR EMBL; CP103166; UVQ96099.1; -; Genomic_DNA.
DR RefSeq; WP_005681424.1; NZ_VVYK01000014.1.
DR STRING; 47678.ERS852494_04063; -.
DR GeneID; 75115119; -.
DR Proteomes; UP000095657; Unassembled WGS sequence.
DR Proteomes; UP000095725; Unassembled WGS sequence.
DR Proteomes; UP000283512; Unassembled WGS sequence.
DR Proteomes; UP000284431; Unassembled WGS sequence.
DR Proteomes; UP000368418; Unassembled WGS sequence.
DR Proteomes; UP000427825; Unassembled WGS sequence.
DR Proteomes; UP000491168; Unassembled WGS sequence.
DR Proteomes; UP001060260; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01392; HTH_LacI; 1.
DR CDD; cd06307; PBP1_sugar_binding; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR025997; SBP_2_dom.
DR PANTHER; PTHR30146:SF145; LACI-FAMILY TRANSCRIPTION REGULATOR; 1.
DR PANTHER; PTHR30146; LACI-RELATED TRANSCRIPTIONAL REPRESSOR; 1.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF13407; Peripla_BP_4; 1.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00356; HTH_LACI_1; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000313|EMBL:RGY27148.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000095657};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 8..62
FT /note="HTH lacI-type"
FT /evidence="ECO:0000259|PROSITE:PS50932"
SQ SEQUENCE 356 AA; 40699 MW; 73D567B03BE3D861 CRC64;
MDKEFSNIRI VDIAKMAGVS VGTVDRVIHN RGRVSEENRK KVQAILEMVN YQPNLMARSL
ASKKQYHFIA ITPSFAQGEY WEAISEGIDK AASEMGSYNI TITKLFFDQY DNKTFDDIVR
NLLDKKVDGV LIATLFTDSV IRLSRELDRF EIPYIYVDSN IEGQHQLAYF GTESYDAGVI
AARLLTDRIS PASDILMARI IHSGKNDSNQ GRNRREGFCR YLKEMRFTGS LHEVELKIND
SVYNFTKLDE IFESNPNIEG AVIFNSTCYI LGNYLKARAM QSVKLVGYDL IERNTQLLSE
GVITALVAQR PERQGYEGIK SLCNHLLFKQ HSEMVNLMPI DILLKENLKY YLNNKL
//
